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U. S. Route 111 was a U. S. Route that ran from Baltimore, Maryland north to the Harrisburg, Pennsylvania area.
It replaced part of the Susquehanna Trail and was in turn replaced by Interstate 83.
Portions of its pre-freeway alignment are now Maryland Route 45 and Interstate 83 Business.
Other old sections in Pennsylvania are now unsigned Quadrant Routes or township-maintained roads.

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