Page "Vaccine controversies" Paragraph 33

In the late 20th century, vaccines were a product with low profit margins, and the number of companies involved in vaccine manufacture declined.

In addition to low profits and liability risks, manufacturers complained about low prices paid for vaccines by the CDC and other US government agencies.

In the early 21st century, the vaccine market greatly improved with the approval of the vaccine Prevnar, along with a small number of other highly-priced blockbuster vaccines such as Gardasil and Pediarix that each provided sales revenues of over $ 1 billion in 2008.