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Members of the Tongva and Juaneño / Luiseño nations long inhabited this area.
After the 1769 expedition of Gaspar de Portolà, a Spanish expedition led by Father Junipero Serra named the area Vallejo de Santa Ana ( Valley of Saint Anne ).
On November 1, 1776, Mission San Juan Capistrano became the areas first permanent European settlement in Alta California, New Spain.

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