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Her first big break came when opening for Chris Rock at Caroline's Comedy Club.

In 1997, she joined the writing team on The Chris Rock Show and also made many appearances on the show.

The writing team was nominated for four Emmys, and in 1999, won for Outstanding Writing for a Variety, Music, or Comedy Special.

Since that time, she has appeared in such films as Pootie Tang and on TV shows such as Curb Your Enthusiasm.

In 2003, she starred in her own short-lived Fox network sitcom, Wanda at Large.

The same year, Sykes appeared in an hour-long Comedy Central special, Tongue Untied.

That network also ranked her No. 70 on its list of the 100 greatest all-time stand ups.

She served as a correspondent for HBO's Inside the NFL, hosted Comedy Central's popular show Premium Blend, and voiced a recurring character named Gladys on Comedy Central's puppet show Crank Yankers.

She also had a short-lived show on Comedy Central called Wanda Does It.