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Introduction

Muscle weakness is now recognized as an uncommon though serious complication of steroid therapy, with most of the synthetic adrenal corticosteroids in clinical use.

Although biopsies have shown structural changes in some of the reported cases of steroid-induced weakness, this case provides the only example known to us in which necropsy afforded the opportunity for extensive study of multiple muscle groups.

The case described in this paper is that of an older man who developed disabling muscular weakness while receiving a variety of steroids for a refractory anemia.