* 1492 – Spain gives Christopher Columbus his commission of exploration.

* 1492 – Christopher Columbus sets sail from Palos de la Frontera, Spain.

Andrea Alciato ( May 8, 1492 – January 12, 1550 ), commonly known as Alciati ( Andreas Alciatus ), was an Italian jurist and writer.

* 1492 – Spain and Christopher Columbus sign the Capitulations of Santa Fe for his voyage to Asia to acquire spices.

Bayezid II was born in Dimetoka Palace ( now Didymoteicho ) in Thrace as the son of Mehmed II ( 1432 – 81 ) and Valide Sultan Mükrime Hatun, the daughter of Süleyman Bey, the sixth ruler of Dulkadirids, who died in 1492.

Eventually, the Knights handed Cem over to Pope Innocent VIII ( 1484 – 1492 ).

* Casimir IV Jagiellon ( 1427 – 1492 ), Polish king

* 1492 – Christopher Columbus becomes the first European to set foot on the island of Hispaniola, now Haiti and the Dominican Republic.

* 1549 – Marguerite of Navarre, wife of Henry II of Navarre ( b. 1492 )

* 1492 31 March – After conquering Granada, the Catholic Monarchs sign the Alhambra decree ordering the expulsion of the Jews from Spain, to be take effect from 31 July 1492.

* 1492 Summer – After the death of the former Duke, his son and heir, Juan Alfonso Perez de Guzman, 3rd Duke of Medina Sidonia saw his lordship over Gibraltar reluctantly renewed by the Catholic Monarchs.

* 1492 – Reconquista: the emirate of Granada, the last Moorish stronghold in Spain, surrenders.

* 1492 – Ferdinand and Isabella The Catholic Monarchs enter Granada, completing the Reconquista.

Lorenzo de ' Medici ( 1 January 1449 – 9 April 1492 ) was an Italian statesman and de facto ruler of the Florentine Republic during the Italian Renaissance.

* 1492 – Queen Isabella of Castille issues the Alhambra decree, ordering her 150, 000 Jewish subjects to convert to Christianity or face expulsion.

At this time, Michelangelo sculpted the reliefs Madonna of the Steps ( 1490 – 1492 ) and Battle of the Centaurs ( 1491 – 1492 ).

Following the breakup of Mali a local leader named Sonni Ali ( 1464 – 1492 ) founded the Songhai Empire in the region of middle Niger and the western Sudan and took control of the trans-Saharan trade.

* 1492 – Peace of Etaples between Henry VII and Charles VIII.

* 1492 – Jami, Persian poet ( b. 1414 )

* 1492 – The Ensisheim meteorite, the oldest meteorite with a known date of impact, strikes the earth around noon in a wheat field outside the village of Ensisheim, Alsace, France.

The known history of Cuba predates Christopher Columbus ' landing on the island during his first voyage of discovery on 28 October 1492.

The first sighting of a Spanish boat approaching the island was on 28 October 1492, probably at Baracoa on the eastern point of the island.

During his first voyage in 1492, instead of reaching Japan as he had intended, Columbus landed in the Bahamas archipelago, at a locale he named San Salvador.

The Caribbean Sea was an unknown body of water to the populations of Eurasia until 1492, when Christopher Columbus first sailed into Caribbean waters on a quest to find a sea route to Asia.

Christopher Columbus reached the island of Hispaniola on his first voyage, in December 1492.

In 1486, Antonio de Nebrija published Las introduciones Latinas contrapuesto el romance al Latin, and the first Spanish grammar, Gramática de la lengua castellana, in 1492.

The first voyage of Christopher Columbus to the New World took place in 1492 as well, beginning the development of the Spanish Empire.

In 1492, under the Catholic Monarchs, the first edition of the Grammar of the Castilian Language by Antonio de Nebrija was published.

Isabella and Ferdinand authorized the 1492 expedition of Christopher Columbus, who became the first known European to reach the New World since Leif Ericson.

Christopher Columbus established a small settlement called La Navidad, near the modern town of Cap Haitien, built from the timbers of his wrecked ship Santa María, during his first voyage in December 1492.

Hispaniola is the site of the first European colonies in the New World, which were founded by Christopher Columbus on his voyages in 1492 and 1493.

Christopher Columbus arrived at the island during his first voyage to America in 1492, where his flagship, the Santa Maria, sank after running aground on Christmas Day.

The Taino were at first tolerant of Columbus and his crew, and helped him to construct La Navidad on what is now Môle Saint-Nicolas, Haiti, in December 1492.

For Europe as a whole, 1500 is often considered to be the end of the Middle Ages, but there is no universally agreed upon end date ; depending on the context, events such as Christopher Columbus's first voyage to the Americas in 1492, conquest of Constantinople by the Turks in 1453, or the Protestant Reformation in 1517 are sometimes used.

Earlier, the guilds of writers had denounced the printing press as " the Devil's Invention ", and were responsible for a 53-year lag between its invention by Johannes Gutenberg in Europe in c. 1440 and its introduction to the Ottoman society with the first Gutenberg press in Istanbul that was established by the Sephardic Jews of Spain in 1493 ( who had migrated to the Ottoman Empire a year earlier, escaping from the Spanish Inquisition of 1492.

The first of them was Rodrigo de Borja (" Borgia " in Italian ), that later became Pope Alexander VI ( 1492 – 1503 ), infamous for his alleged corruption and immorality.

The huge wealth from the Americas was still to arrive as Columbus ' first voyage and the surrender of Granada were both in 1492.

Europeans first landed on the island in either 1492 or 1502 during Spain's early exploration of the Caribbean.

* 1492 – Christopher Columbus sails from La Gomera in the Canary Islands, his final port of call before crossing the Atlantic for the first time.

The word " Biafra " appeared for the first time in the ancient map of Africa drawn by the Portuguese from 1492 to 1729 when it was spelt as Biafara, Biafar, and Biafares.

* August 11 – Pope Alexander VI succeeds Pope Innocent VIII as the 214th pope, after the 1492 papal conclave, the first held in the Sistine Chapel.

< imagemap > File: 2nd millennium montage. png | From left, clockwise: In 1492, Christopher Columbus ; The American Revolution ; The French Revolution ; The Atomic Bomb from World War II ; An alternate source of light, the Light Bulb ; For the first time, a human being sets foot on the moon in 1969 during the Apollo 11 moon mission ; Aeroplanes become the most-used way of transport though the skies ; Napoleon Bonaparte, in the early 19th century, affects France and Europe on subjects of expansionism and modernization ; Alexander Graham Bell's telephone ; In 1348, the Black Death kills over 100 million people worldwide, and over half of Europe, in two years.

According to historian Alfred W. Crosby Jr. in his The Columbian Exchange: Biological and Cultural Consequences of 1492, this outbreak is the first widely documented epidemic in the New World.