* 1496 – King Manuel I of Portugal issues a decree of expulsion of " heretics " from the country.

* Margherita Gonzaga ( 13 July 1496 – 22 September 1496 ).

* 1496 – Leonardo da Vinci unsuccessfully tests a flying machine.

* 1561 – Menno Simons, Dutch Mennonite leader ( b. 1496 )

La Malinche (; c. 1496 or c. 1505 – c. 1529 ), known also as Malinalli, Malintzin or Doña Marina, was a Nahua woman from the Mexican Gulf Coast, who played a role in the Spanish conquest of Mexico, acting as interpreter, advisor, lover, and intermediary for Hernán Cortés.

* 1496 – Gustav I of Sweden ( d. 1560 )

* 1559 – Anthony St. Leger, Lord Deputy of Ireland ( b. 1496 )

* 1496 – Sigismund of Austria ( b. 1427 )

* 1427 – Archduke Sigismund of Austria ( d. 1496 )

* 1570 – João de Barros, Portuguese historian ( b. 1496 )

1416 / 18 – 1496 ) to defend the Bolbitine branch of the Nile at Rashid.

* Sigismund, Archduke of Austria ( 1427 – 1496 ), ruler of Further Austria

* Sigismund, Archduke of Austria ( 1427 – 1496 )

He only went to war twice, once in 1489 during the Breton crisis and the invasion of Brittany, and in 1496 – 1497 in revenge for Scottish support of Perkin Warbeck and for their invasion of Northern England.

* Gustav Vasa ( 1496 – 1560 ), King of Sweden

* Juan de Flandes ( 1460 – 1519 ), Early Netherlandish painter who was active in Spain from 1496 to 1519 at the court of Isabella I of Castile.

* August 26 – King Ferdinand II of Naples ( d. 1496 )

* April 12 – Claude, Duke of Guise, French soldier ( b. 1496 )

Tyndale was born at some time in the period 1484 – 1496, possibly in one of the villages near Dursley, Gloucestershire.

* March 20 – Richard Maitland, Scottish statesman and historian ( b. 1496 )

* March 3 – Sebastiano Venier, Doge of Venice ( b. 1496 )

* October 20 – João de Barros, Portuguese historian ( b. 1496 )

* March 16 – Anthony St. Leger, Lord Deputy of Ireland ( b. 1496 )

* Church of St. Nicolas and St. Mary, Mitterndorf ( 1496 )

* June 25 – Mary Tudor, queen of Louis XII of France ( b. 1496 )

Mary Tudor ( 18 March 1496 – 25 June 1533 ) was the younger sister of King Henry VIII of England and queen consort of France through her marriage to Louis XII.

After the death of Anne, Louis married Mary Tudor ( 1496 – 1533 ), the sister of King Henry VIII of England, in Abbeville, France, on 9 October 1514.

In May 1515 he married Mary Tudor, Queen Dowager of France ( 18 March 1496 – 25 June 1533 ).

* Claude, Duke of Guise ( 1496 – 1550 ; s. 1528 ) ( Claude ) ( Father of Mary of Guise mother of Mary, Queen of Scots )

* Mary Tudor ( queen consort of France ) ( 1496 – 1533 ), queen consort of Louis XII of France

Sir Anthony St Leger or Sellenger ( c. 1496 – 16 March 1559 ) of Ulcombe and Leeds Castle, Kent, was an English politician and Lord Deputy of Ireland during the Tudor period.

George was married at Dresden, on 21 November 1496, to Barbara Jagiellon, daughter of Casimir IV, King of Poland and Elisabeth, daughter of Albrecht II of Hungary.

On 20 October 1496, he married Infanta Joanna, daughter of King Ferdinand II of Aragon and Queen Isabella I of Castile, in Lier, Belgium.

He married his half-aunt Joanna in 1496, shortly before his death ( she was the daughter of his grandfather Ferdinand and his second wife, Joanna of Aragon ; Joanna, born in 1478, a late child of a second marriage, was actually younger than Ferdinand ).

It houses a sarcophagus of Bianca Landriani ( 1496 ), daughter of Caterina Sforza.

Born in Naples to Ferdinand I and his first wife, Isabella of Taranto, the daughter of Tristan, Count of Copertino and Caterina Orsini, he succeeded his childless nephew Ferdinand II after the latter's early death in 1496, at the age of 28.

* April 15 – Henry Somerset, 2nd Earl of Worcester ( b. 1496 )

The current spelling is recorded at least as far back as 1496, in a letter from Henry VII.

Indeed, it appears that wool became such a source of riches for the town that when, in 1496, Henry VII needed to raise money to fight the Scots, he called upon the wool-merchants of Shepton to contribute £ 10 to the cause:

* Henry Thomson of Keillour ( 1496 – 1512 )

The title fell into abeyance in 1496 on the death of Henry Grey, known as the seventh Baron, and after 493 years was terminated in the favour of Charles Cornwall-Legh, subsequently fifth Baron after the re-dating.

* Henry Grey, 4th ( 7th ) Baron Grey of Codnor ( 1435 – 1496 ) ( abeyant 1496 )

Henry Somerset, 2nd Earl of Worcester ( c. 1496 – 26 November 1549 ) was an English nobleman, son of Charles Somerset, 1st Earl of Worcester and Elizabeth Herbert, 3rd Baroness Herbert.

A chantry was constructed in the year 1400 by the Byrons — the then Lords of the Manor — and a chapel for the wider community in 1496 ; A document dated 20 March 1496, during the reign of Henry VII, proclaims that open land by the River Beal would be the site of the new chapel.

* Nicholas Carew ( courtier ) ( c. 1496 – 1539 ), courtier and statesman during the reign of Henry VIII of England, husband of Elizabeth Carew

After stating that Sebastian ( should be John ) " Cabotte " was sent out by King Henry VII in 1496 ( should be 1497 ) to find the passage from the Atlantic Ocean to the Pacific, and that " one Caspar Cortesreales, a pilot of Portingale ", had visited these islands on the north coast of North America in 1500, the document continues:

King Henry VII granted the lands to Simon Digby in 1496.

Simon Digby was awarded the manor of Coleshill in 1496 by King Henry VII, following the Battle of Bosworth and the execution of Simon de Montford for helping in the attempt to oust the King.

Henry VII negotiated the favourable Intercursus Magnus treaty in 1496.