* 1503 – King James IV of Scotland marries Margaret Tudor, daughter of King Henry VII of England at Holyrood Abbey in Edinburgh, Scotland.

* 1503 – Christian III of Denmark ( d. 1559 )

* 1503 – The Battle of Cerignola is fought.

Around 1503 – 1505 he produced the first seventeen of a set illustrating the Life of the Virgin, which he did not finish for some years.

* House of Bourbon ( 1268 – 1503 )

Coming from modest beginnings in Savona, Liguria, the family rose to prominence through nepotism and ambitious marriages arranged by two Della Rovere popes, Francesco della Rovere, who ruled as Pope Sixtus IV ( 1471 – 1484 ) and his nephew Giuliano ( Pope Julius II, 1503 – 1513 ).

* 1503 – Nostradamus, French astrologer ( d. 1566 )

* 1471 – Piero di Lorenzo de ' Medici, Italian ruler ( d. 1503 )

* 1466 – Elizabeth of York, wife of Henry VII of England ( d. 1503 )

* Ferdinand I, Holy Roman Emperor ( 1503 – 1564 )

# Gumprecht ( 16 July 1503, Ansbach – 25 June 1528, Naples ), a canon in Bamberg.

* Andrzej Frycz Modrzewski ( 1503 – 1572 )

# Agnes ( b. Dresden, 7 January 1503 – d. Dresden, 16 April 1503 ).

Mai Ali Gazi ibn Dunama ( c. 1475 – 1503 ) defeated the Bilala, reestablishing complete control of Kanem.

* Ippolita Gonzaga ( 13 November 1503 – 16 March 1570 ), a nun.

* 1503 – Parmigianino, Italian artist ( d. 1540 )

* 1503 – Wilhelm von Grumbach, German adventurer ( d. 1567 )

* 1503 – Anne of Bohemia and Hungary ( d. 1547 )

The Mona Lisa, Leonardo da Vinci, oil on panel, 1503 – 19, probably completed while the artist was at the court of Francis I of France | Francis I.

Mona Lisa or La Gioconda ( 1503 – 1505 / 1507 )— Louvre, Paris, France

* 1446 – Margaret of York, wife of Charles I, Duke of Burgundy ( d. 1503 )

The first such recorded example is that of Ludovico di Varthema of Bologna in 1503.

* 1503 – Agnolo di Cosimo, Italian painter ( d. 1572 )

* February 15 – Piero di Lorenzo de ' Medici, ruler of Florence ( d. 1503 )

* August 4 – Lorenzo di Pierfrancesco de ' Medici, Italian patron of the arts ( d. 1503 )

Among these were Hermann, " bacalaurio in medicina ", astrologist Baptista de Vesentio, Maestro Zoano barbero from Genoa ( in 1468 ), Isaac Beg ( in 1473 ), Don Antonio Branca ( skilled in fixing cut noses ), Mateo Muriano from Venice ( in 1502 ), and Hieronimo di Cesena from Venice ( in 1503 ).

* 1503 in art-Birth of Agnolo di Cosimo

* Piero di Lorenzo de ' Medici ( 1471 – 1503 ) ( the Unfortunate, also Piero II de ' Medici ), son of Lorenzo the Magnificent

Lorenzo di Pierfrancesco de ' Medici ( August 4, 1463 – May 20, 1503 ), nicknamed the Popolano, was an Italian banker and politician, and the brother of Giovanni il Popolano.

However, he was defeated in the battle of Ruvo di Puglia ( 1503 ) and made prisoner by Gonzalo Fernández de Córdoba.

In 1503 it was the location of the disfida di Barletta (" Joust of Barletta "), a battle during which 13 Italian knights commanded by Ettore Fieramosca challenged and defeated an equal number of French knights who were at the time prisoners of war, in a joust held near Andria.

Agnolo di Cosimo ( November 17, 1503 – November 23, 1572 ), usually known as Il Bronzino, or Agnolo Bronzino ( mistaken attempts also have been made in the past to assert his name was Agnolo Tori and even Angelo ( Agnolo ) Allori ), was an Italian Mannerist painter from Florence.

Although Burton was not the first non-Muslim European to make the Hajj ( that distinction belonging to Ludovico di Barthema in 1503 ), his pilgrimage is the most famous and the best documented of the time.

# Bianca ( b. Rome, March 1478-d. after 1522 ), married firstly in 1494, Astorre III Manfredi, Lord of Faenza ( d. 1502 ), and secondly in 1503, Troilo Rossi ( d. 1521 ), the first Marchese di San Secondo.

* Bronzino ( proper name Agnolo di Cosimo ), ( 1503 – 1572 ), Florentine painter

The Travels of Ludovico di Varthema in Egypt, Syria, Arabia Deserta and Arabia Felix, in Persia, India, and Ethiopia, A. D. 1503 to 1508.

The travels of Ludovico di Varthema in Egypt, Syria, Arabia Deserta and Arabia Felix, in Persia, India, and Ethiopia, A. D. 1503 to 1508 ( 1863 ).

The term was first coined by the Florentine explorer Amerigo Vespucci, in a letter written to his patron Lorenzo di Pier Francesco de ' Medici in the Spring of 1503, and published ( in Latin ) in 1503-04 under the title Mundus Novus.

At the beginning of the 16th century, during the guerilla war between the French and the Spanish over possession of Southern Italy, the city was the theater of a historical victory of Italian knights over French prisoners, in what became known as the Challenge of Barletta ( 13 February 1503 ).

* Ettore Fieramosca ( 1476 – 1515 ), head of the Italian knights participating in the famous Joust of Barletta in 1503.

There is evidence that he moved from Genoa to Barletta in 1501, where he became a servant of King Frederick of Naples, leaving in 1503 for Venice, where he rejoined his father Dom Isaac.