* 1503 – King James IV of Scotland marries Margaret Tudor, daughter of King Henry VII of England at Holyrood Abbey in Edinburgh, Scotland.

* 1503 – Christian III of Denmark ( d. 1559 )

* 1503 – The Battle of Cerignola is fought.

Around 1503 – 1505 he produced the first seventeen of a set illustrating the Life of the Virgin, which he did not finish for some years.

* House of Bourbon ( 1268 – 1503 )

Coming from modest beginnings in Savona, Liguria, the family rose to prominence through nepotism and ambitious marriages arranged by two Della Rovere popes, Francesco della Rovere, who ruled as Pope Sixtus IV ( 1471 – 1484 ) and his nephew Giuliano ( Pope Julius II, 1503 – 1513 ).

* 1471 – Piero di Lorenzo de ' Medici, Italian ruler ( d. 1503 )

* 1503 – Disfida di Barletta – famous challenge between 13 Italian and 13 French knights near Barletta.

* 1466 – Elizabeth of York, wife of Henry VII of England ( d. 1503 )

* Ferdinand I, Holy Roman Emperor ( 1503 – 1564 )

# Gumprecht ( 16 July 1503, Ansbach – 25 June 1528, Naples ), a canon in Bamberg.

* Andrzej Frycz Modrzewski ( 1503 – 1572 )

# Agnes ( b. Dresden, 7 January 1503 – d. Dresden, 16 April 1503 ).

Mai Ali Gazi ibn Dunama ( c. 1475 – 1503 ) defeated the Bilala, reestablishing complete control of Kanem.

* Ippolita Gonzaga ( 13 November 1503 – 16 March 1570 ), a nun.

* 1503 – Parmigianino, Italian artist ( d. 1540 )

* 1503 – Wilhelm von Grumbach, German adventurer ( d. 1567 )

* 1503 – Anne of Bohemia and Hungary ( d. 1547 )

The Mona Lisa, Leonardo da Vinci, oil on panel, 1503 – 19, probably completed while the artist was at the court of Francis I of France | Francis I.

Mona Lisa or La Gioconda ( 1503 – 1505 / 1507 )— Louvre, Paris, France

* 1446 – Margaret of York, wife of Charles I, Duke of Burgundy ( d. 1503 )

Michel de Nostredame ( 14 or 21 December 1503 – 2 July 1566 ), usually Latinised as Nostradamus, was a French apothecary and reputed seer who published collections of prophecies that have since become famous worldwide.

* 1503: Nostradamus was born on either December 14, or December 21.

* July 2 – Nostradamus, French astrologer ( b. 1503 )

** Charles Estienne, French anatomist ( b. 1503 )

* September 7 – Robert Estienne, French printer ( b. 1503 )

It is likely that he first became a mercenary and marched with the French army to Italy, where he fought in the battle of Garigliano on 28 December 1503.

For a time, Pope Alexander VI ( 1492 – 1503 ), the unsavory Rodrigo Borja, tolerated fra Girolamo ’ s strictures against the Church, but he was moved to anger when Florence declined to join his new Holy League against the French invader and blamed it on Savonarola ’ s pernicious influence.

In 1503, the River was the site of a battle between Spanish and French forces, in which Piero II de ' Medici was drowned, passing control of the Medici family to Giovanni de ' Medici, later Pope Leo X.

In 1503 however, as the French and Spanish continued their struggle in Italy over the Kingdom of Naples, Piero was drowned in the Garigliano River while attempting to flee the aftermath of the battle, which the French ( with whom he was allied ) had lost.

In 1503 he was fighting in Corsica in the service of Genoa, at that time under French vassalage, and he took part in the rising of Genoa against the French, whom he compelled to evacuate the city.

In 1503 it was the location of the disfida di Barletta (" Joust of Barletta "), a battle during which 13 Italian knights commanded by Ettore Fieramosca challenged and defeated an equal number of French knights who were at the time prisoners of war, in a joust held near Andria.

At the beginning of the 16th century, during the guerilla war between the French and the Spanish over possession of Southern Italy, the city was the theater of a historical victory of Italian knights over French prisoners, in what became known as the Challenge of Barletta ( 13 February 1503 ).

For a short time he lived in peace undisturbed ; but when the city was taken by the French, bereft of all his possessions, he followed the young king, Ferdinand, in 1495, to Messina ; then went to Corfu ; and in 1496 settled in Monopoli, and lastly ( 1503 ) in Venice, where his services were employed in negotiating a commercial treaty between Portugal and the Venetian republic.

In 1500, they occupied the strategically important fortress of Bellinzona, which the French king Louis XII, who ruled Milan at that time, ceded definitively in 1503.

Perhaps the most famous occurred in 1503 when Consalvo of Cordova defeated the French army under the command of the Duke of Nemours, an action known as the Battle of the Garigliano.

In 1503, hired by Ferdinand II of Spain, he was determinant in the victory at the Battle of Garigliano over the French army, which started the Spanish domination over southern Italy.

Nicholas Bourbon ( 1503 or 1505-after 1550 ) was a French court preceptor and poet.

The Battle of Cerignola was fought on April 28, 1503, between Spanish and French armies, in Cerignola, near Bari in Southern Italy.

The word buskin, only recorded in English since 1503 meaning " half boot ", is of unknown origin, perhaps from Old French brousequin ( in modern French brodequin ) or directly from its Middle Dutch model brosekin " small leather boot ".

He continued in the service of Gonzalo Fernández de Córdoba and went on to Naples, and defended Canosa in 1502 and Taranto in 1503 against the French.