* 1621 – Cristofano Allori, Italian painter ( b. 1577 )

* 1621 – Guillaume du Vair, French writer ( b. 1556 )

* 1621 – Gerbrand van den Eeckhout, Dutch painter ( d. 1674 )

He was the father of the painter Cristofano Allori ( 1577 – 1621 ).

* 1578 – Philip III of Spain ( d. 1621 )

* 1682 – Avvakum, Russian priest and writer ( b. 1621 )

* 1621 – The Mayflower sets sail from Plymouth, Massachusetts on a return trip to England.

Ambrosius Bosschaert the Elder ( 18 January 1573 – 1621 ) was a still life painter of the Dutch Golden Age.

* 1621 – Roger Boyle, 1st Earl of Orrery, English soldier, statesman, and dramatist ( d. 1679 )

(; 4 October 1542 – 17 September 1621 ) was an Italian Jesuit and a Cardinal of the Catholic Church.

Under Pope Paul V ( reigned 1605 – 1621 ), a major conflict arose between Venice and the Papacy.

* 1621 – Charles d ' Albert, Constable of France ( b. 1578 )

* 1621 – Saint Job of Maniava, Ukrainian Orthodox Saint ( b. 1550 )

* 1621 – Rebecca Nurse, English colonist executed during Salem witch trials ( d. 1692 )

* 1571 – Michael Praetorius, German composer ( d. 1621 )

* 1621 – Myles Standish is appointed as first commander of Plymouth colony.

* 1621 – Johannes Schefferus, Alsatian humanist ( d. 1679 )

* 1621 – Gregory XV becomes Pope, the last Pope elected by acclamation.

During the 17th century, the French fabulist Jean de La Fontaine ( 1621 – 1695 ) saw the soul of the fable in the moral — a rule of behavior.

* Jean de La Fontaine ( French, 1621 – 95 ).

* 1621-Second battle of Gibraltar on which a Spanish squadron crushed the VOC at the strait of Gibraltar – Battle of Gibraltar ( 1621 )

Galileo initially called his discovery the Cosmica Sidera (" Cosimo's stars "), in honour of Cosimo II de ' Medici ( 1590 – 1621 ).

In his reign ( 1598 – 1621 ) a ten year truce with the Dutch was overshadowed in 1618 by Spain's involvement in the European-wide Thirty Years ' War.

Philip III was succeeded in 1621 by his son Philip IV of Spain ( reigned 1621 – 1665 ).

* July 22 – Katarina Stenbock, queen of Gustav I of Sweden ( d. 1621 )

Catherine Stenbock ( Swedish: Katarina Gustavsdotter Stenbock ; born at Torpa, Tranemo Municipality, Västergötland on 22 July 1535 – died at Strömsholm, Västmanland on 13 December 1621 ) was the third and last consort of King Gustav I of Sweden, and Queen consort of Sweden between 1552 and 1560.

* 1535 – Catherine Stenbock, Swedish wife of Gustav I of Sweden ( d. 1621 )

After Albert's childless death in 1621, Luxembourg passed to his great-nephew and heir Philip IV of Spain, who through his paternal grandmother Anna of Austria, queen of Spain, Albert's sister, was the primogenitural heir to the Queen Elisabeth of Poland.

She was first married at the palace in Stockholm on 13 November 1645 to the nobleman, Axel Turesson Natt och Dag ( 1621 – 47 ), Queen Christina's chamberlain.

Elisabeth of France ( 22 November 1602 – 6 October 1644 ) was Queen consort of Spain ( 1621 to 1644 ) and Portugal ( 1621 to 1640 ) as the first wife of King Philip IV of Spain.

As colonel, Gustav Horn took part in siege of Riga in 1621 and was seriously wounded.

The university library of Uppsala was mainly created through the large donations in the early 17th century of confiscated libraries from monasteries, especially that in Vadstena, and the important collection of Baron Hogenskild Bielke who had been executed in 1605 and whose library was confiscated by the crown and donated by Gustav Adolph in 1621.

Richard II, was the son of Col. Richard Lee I, Esq., " the immigrant " ( 1618 – 1664 ) and Anne Constable ( c. 1621 – 1666 ).

Continuing from the reign of Elizabeth I of England, the creation of grants and patents reaches a new highwater mark from 1614 to 1621, during the reign of James I of England.

In January 1621 he traveled to England as the secretary of six envoys of the United Provinces with the object of persuading James I to support the German Protestant Union, returning in April of that year.

In 1621, the House of Lords resumed its judicial role when King James I sent the petition of Edward Ewer, a persistent litigant, to be considered by the House of Lords.

* Nova Scotia ; founded by a Royal Charter issued in 1621 by King James I

* History of England from the Accession of James I to the Outbreak of the Civil War, 1603 – 1642 by Samuel Rawson Gardiner ( 1883 ): Volume I ( 1603 – 1607 ), Volume II ( 1607 – 1616 ), Volume III ( 1616 – 1621 ), Volume IV ( 1621 – 1623 ), Volume V ( 1623 – 1625 ), Volume VI ( 1625 – 1629 ), Volume VII ( 1629 – 1635 ), Volume VIII ( 1635 – 1639 ), Volume IX ( 1639 – 1641 ), Volume X ( 1641 – 1642 )

The gardens became commonly used as a place of relaxation, and James Howell wrote in 1621 that " I hold Inn Walks to be the pleasantest place about London, and that there you have the choicest society ".

His defence of his father against the attacks of certain Catholics ( Pietas contra maledicos patrii Nominis et Religionis Hostes, 1621 ), secured him the notice and favour of James I, who conferred upon him a prebendal stall in Canterbury Cathedral ( stall IX ) which he held from 1628 to his death.

Sandys sat in the later parliaments of James I as MP for Sandwich in 1621, and for Kent in 1624.

* Cosimo II 1609 – 1621 – Son of Ferdinando I.

In 1621 Russell was one of the thirty-three peers who petitioned James I on the prejudice caused to the English peerage by the lavish grant of Irish and Scottish titles of nobility.

He became President of the Council in 1621, in which office he was continued by Charles I, who created him Earl of Manchester in 1626.

In the 1620s a group of Scots was sent by Charles I to set up a colony, and the Latin name is used in Sir William Alexander's 1621 land grant.

* 1621: James I of England ( VI of Scotland ) grants Acadia to Sir William Alexander who renames it New Scotland ( Nova Scotia )

But he was liberated on 16 July 1621, after the new Lord Chancellor John Williams had prevailed with George Villiers, 1st Duke of Buckingham to recommend to James I an exercise of his prerogative of mercy in the case of political prisoners.

In 1621, King James I directed the Privy Council to establish a temporary committee to investigate the causes of a decline in trade and consequent financial difficulties.

James I, painted by Daniel Mytens in 1621.

Greville obtained from James I a grant of Warwick Castle, and in 1621 he was raised to the Peerage of England as Baron Brooke, of Beauchamps Court in the County of Warwick, with remainder to his second cousin ( once removed ), and adopted son, Robert Greville.