CML is now largely treated with targeted drugs called tyrosine kinase inhibitors ( TKIs ), such as Gleevec / Glivec ( imatinib ), Sprycel ( dasatinib ), Tasigna ( nilotinib ), or Bosulif ( bosutinib ) which have led to dramatically improved long term survival rates ( 95. 2 %) since the introduction of Gleevec in 2001.

Symptoms of CML may include: enlarged spleen causing pain on the left side, malaise, joint and / or hip pain, low-grade fever, increased susceptibility to infections, anemia, and thrombocytopenia with easy bruising ( although an increased platelet count ( thrombocytosis ) may also occur in CML ).

The small subset of patients without detectable molecular evidence of bcr-abl fusion may be better classified as having an undifferentiated myelodysplastic / myeloproliferative disorder, as their clinical course tends to be different from patients with CML.

Recently Chemgenex released results of their open-label Phase 2 / 3 study ( CGX-635-CML-202 ) which investigated the use of their non-targeted agent omacetaxine, administered subcutaneously in CML patients who had failed imatinib and who have the highly drug-resistant T315I kinase domain mutation.

Current mode logic ( CML ), or source-coupled logic ( SCL ), is a differential digital logic family intended to transmit data at speeds between 312. 5 Mbit / s and 3. 125 Gbit / s over a standard printed circuit board.

* Introduction to LVDS, PECL, and CML, Maxim, http :// pdfserv. maxim-ic. com / en / an / AN291. pdf

However, at present the test of choice in adults to distinguish CML is an assay for the presence of the Philadelphia chromosome, either via cytogenetics and FISH, or via PCR for the BCR / ABL fusion gene.

Identification of the Philadelphia chromosome by cytogenetics is diagnostic for CML.

When these are very abundant it can be a feature of infection or leukemia, although the most common types of leukemia ( CML and CLL ) are characterised by mature cells, and have more of an abnormal appearance on light microscopy ( additional tests can aid the diagnosis ).

A potentially curative, but risky option for pediatric Ph + ALL or Ph + CML includes bone marrow transplant or cord blood transplant, but chemotherapy is favored by some for achieving first remission ( CR1 ).

A bone marrow biopsy is often performed as part of the evaluation for CML, and CML is diagnosed by detecting the Philadelphia chromosome.

Chronic phase CML is treated with inhibitors of tyrosine kinase, the first of which was imatinib mesylate ( marketed as Gleevec or Glivec ; previously known as STI-571 or CGP57148B ) approved by the United States FDA in 2001.

Although few leukemic cells persist in most patients as evaluated by RT-PCR, and treatment has to be continued indefinitely, CML is the first cancer in which a medical treatment ( imatinib ) can give to the treated patients a normal life expectancy.

The first, dasatinib, is a TK inhibitor that blocks several oncogenic proteins and was initially approved by the US FDA in 2007 to treat CML patients who were either resistant to or intolerant of imatinib.

Publishers can distribute chemistry within XML documents by using CML, e. g. in RSS documents.

The ECL family, ECL is also known as current-mode logic ( CML ), was invented by IBM as current steering logic for use in the transistorized IBM 7030 Stretch computer, where it was implemented using discrete components.

CML data files are accepted by many tools, including JChemPaint, Jmol, XDrawChem and MarvinView.

< em style =" color: green ; font-style: normal "> bcr-abl kinase </ em >, which causes Chronic myelogenous leukemia | CML, inhibited by < em style =" color: red ; font-style: normal "> imatinib </ em > ( small molecule ).

Two type of warheads were provided for the Vigilant: A British developed warhead with a collapsible probe that extends on launch which can achieve maximum penetration, and one developed by Swiss firm CML with a blunter nose which has a harden steel ring which on oblique strikes will dig into the armor and swing the shape charge warhead around for better penetration.

In CML, the gene is activated by being translocated within the BCR ( breakpoint cluster region ) gene on chromosome 22.

* The National CML Society ( US )

* CML information from The Leukemia & Lymphoma Society

Command of the CML is still a coveted assignment, and the Military Village ( Vila Militar ), Rio de Janeiro's garrison or military community, is still considered one of the most important centers of military influence in the entire country.

The medicine, called Bosulif, treats chronic myelogenous leukemia ( CML ), a blood and bone marrow disease that usually affects older adults.

Computer Labs: Advanced Projects Lab ( APL ), Advanced Teaching Lab ( ATL ), Communication & Marketing Labs ( CML ) 1, 2, and Journalism Lab ( JRL )

* Camarillo ( Amtrak station ) ( station code CML ), a train station in California, United States

Chronic myelogenous ( or myeloid ) leukemia ( CML ), also known as chronic granulocytic leukemia ( CGL ), is a cancer of the white blood cells.

* Lower levels are found in chronic myelogenous leukemia ( CML ), paroxysmal nocturnal hemoglobinuria ( PNH ) and acute myelogenous leukaemia ( AML ).

* Eastern Military Command ( Commando Militar do Leste ; CML ), ( HQ: Rio de Janeiro )-1st and 4th Military Regions

Chloromas may occur in patients with a diagnosis of myelodysplastic syndrome ( MDS ) or myeloproliferative syndromes ( MPS ) ( e. g. chronic myelogenous leukemia ( CML ), polycythemia vera, essential thrombocytosis, or myelofibrosis ).

Examples of AGE-modified sites are carboxymethyllysine ( CML ), carboxyethyllysine ( CEL ), and Argpyrimidine, which is the most common epitope.

Called subthreshold CML or subthreshold source coupled logic ( STSCL ), the consumption of each gate can be reduced down to few tens of pico-Amperes.

However, leukemoid reactions can resemble more serious conditions such as chronic myelogenous leukemia ( CML ), which can present with identical findings on peripheral blood smear.

The program is designed to meet requirements such as those from the Financial Services Authority ( FSA ), and has sample configurations provided for both the FSA and the Council of Mortgage Lenders ( CML ) reporting environments.

* Reading MDL Molfiles, CML ( Chemical Markup Language ), ChemDraw binary format, ChemDraw XML text format

Students in grade 4 to 5 take part in CML ( Continental Math League ), and the students who get the most questions right get awards.

* CPL / CTP conferred by Transport & Logistics Certification Council ( TLCC ) of Australia,

In the mid-1970s, there was a brief resurgence of talent, energized by Cuti, artist Joe Staton and the " CPL Gang " — a group of writer / artist comics fans including John Byrne, Roger Stern, Bob Layton, and Roger Slifer, who had all worked on the fanzine CPL ( Contemporary Pictorial Literature ).

The CPL 4-Year Anniversary Event-6 / 28 / 01 > 7 / 1 / 01

In computing, the CPL ( Common Public License ) is a free software / open-source software license published by IBM.

( PPL, CPL, ATPL, SEP, MEP, FI, CRI, TRI, IRI, IR / SE, IR / ME, TR-C500 / 550 / 560, TR PA42, ARB. AS )

* ( PPL, CPL, ATPL, SEP, MEP, FI, CRI, IRI, TRI PA42, TRI C500 / 550 / 560, ARB, AS )

** 1 identifies a Private ( PVT ) through Specialist ( SPC / Pay Grade E-4 ) or Corporal ( CPL / also Pay Grade E-4 )

Cost per mille is one of the most common marketing practice used on the internet along with Cost per click ( CPC / PPC ) and Cost per action ( CPA ) ( including CPL and CPS ).

* Collected papers of Christopher Strachey, section pertaining to CPL, archived at the Bodleian Library, Oxford ; CSAC 71. 1. 80 / C. 136-C. 184

A commercial pilot license ( CPL ), is a qualification that permits the holder to act as the pilot in command of a single pilot aircraft, or as co-pilot of a multi-pilot aircraft and be paid for his / her work.

The states give different terms for licenses or permits to carry a concealed firearm, such as a Concealed Handgun License / Permit ( CHL / CHP ), Concealed Carry Weapons ( CCW ), Concealed ( Defensive / Deadly ) Weapon Permit / License ( CDWL / CWP / CWL ), Concealed Carry Permit / License ( CCP / CCL ), License To Carry ( Firearms ) ( LTC / LTCF ), Carry of Concealed Deadly Weapon license ( CCDW ), Concealed Pistol License ( CPL ), etc.