So we asked such men in major companies in the design field to offer their opinions on the `` dual-road-up '' problem -- and more importantly -- their solutions.

A well-publicized entrant which has achieved success only recently is the built liquid detergent, with which the major problem today is incorporation of builder and active into a small volume using a sufficiently high builder/active ratio.

Our major problem is what an enemy might accomplish in an initial attack on a target.

However, a major problem here is one of scale of processing ; ;

Hardly a window has been broken since Dunbar first was opened ( and vandalism in schools is a major problem in many slum areas ).

Indeed, the problem of determining the area of plane figures was a major motivation for the historical development of calculus.

In medicine, the major problem of the emergence of resistant bacteria is due to misuse and overuse of antibiotics.

The authors noted an apparent superior efficacy of olanzapine to the other drugs in terms of reduction in psychopathology and rate of hospitalizations, but olanzapine was associated with relatively severe metabolic effects such as a major weight gain problem ( averaging over 18 months ) and increases in glucose, cholesterol, and triglycerides.

The questions can concern anything from a major policy issue to a specific constituent's problem.

This became a major problem as bidding wars between the ballclubs to land the best amateur players escalated signing bonuses.

Another major problem in cosmology is what caused the universe to contain more particles than antiparticles.

The P versus NP problem is a major unsolved problem in computer science.

A major problem in determining whether the Cimbri were speaking a Celtic or a Germanic language is that at this time the Greeks and Romans tended to refer to all groups to the north of their sphere of influence as Gauls, Celts, or Germani rather indiscriminately.

Further, 43 percent of respondents said they use less than half the functionality of their existing system ; 72 percent indicated they would trade functionality for ease of use ; 51 percent cited data synchronization as a major issue ; and 67 percent said that finding time to evaluate systems was a major problem.

Chronic Chagas disease remains a major health problem in many Latin American countries, despite the effectiveness of hygienic and preventive measures, such as eliminating the transmitting insects.

The disease was named after the Brazilian physician and infectologist Carlos Chagas, who first described it in 1909, but the disease was not seen as a major public health problem in humans until the 1960s ( the outbreak of Chagas disease in Brazil in the 1920s went widely ignored ).

In an account that had become standard by the mid-century, Hilbert's problem set was also a kind of manifesto, that opened the way for the development of the formalist school, one of three major schools of mathematics of the 20th century.

Thus far, pyrethroid resistance in Anopheles has not been a major problem.

This prediction came true at least in part: Doom became a major problem at workplaces, both occupying the time of employees and clogging computer networks with traffic caused by deathmatches.

The Stammbaumtheorie proved to be very productive for comparative linguistics, but didn't solve the major problem of studying the origin of language: the lack of fossil records.

In the 21st-century Egypt has encountered a major problem with immigration, as millions of Africans attempt to enter Egypt fleeing poverty and war.

A major problem at that time was the lack of fossil intermediaries.

Not a single Southern author, major or minor, has made the urban problems of an urban South his primary source material.

The major effect of these advances appears to lie in the part they have played in the industrial revolution and in the tools which scientific understanding has given us to build and manipulate a more protective environment.

The Charles Men has a tremendous range of characters, of common folk even more than of major figures.

Carl has been married to Paula for fifty-three years, and he has not made a single major decision without careful consideration and thorough discussion with his wife.

No action has been taken, however, on such major problems as ending the fee system, penal reform, modification of the county unit system and in outright banning of fireworks sales.

The accepted method of writing news has two major liabilities.

Arthur Hays Sulzberger has been a distinguished publisher of this distinguished newspaper and it is fitting that we take due notice of his major contribution to American journalism on the occasion of his retirement.

In fact, one of the major reasons for the failure of the ill-starred expedition appears to have been a lack of full information on the extent to which Cuba has been getting this Russian military equipment.

More than one president has found that a long-range plan helps him to attract major gifts.

Gradually watercolor claimed his greater affection until today it has become his major, if not exclusive, technique.

Over the years, beginning in 1929, Mason has been awarded seventeen major prizes including two gold medals ; ;

The shooting development program of the Sporting Arms and Ammunition Manufacturers' Institute has successfully published these facts in all major outdoor magazines, many national weeklies and the trade papers.

The major reason for this is that it has no quick-kill effect.

This is why this approach to BW defense has not been given major attention.

When all has been said, however, the big branch store remains a major break with history in the development of American retailing.

Of course, nationalism has really outlived its usefulness in a country as world-oriented as ours, and its continued existence reflects one of the major culture lags of the twentieth-century United States.

The accelerated pace of metropolitan changes has accentuated the drive to conformity in congregations of the major denominations.

`` This is one of the major items in the Fulton County general assistance program '', the jury said, but the State Welfare Department `` has seen fit to distribute these funds through the welfare departments of all the counties in the state with the exception of Fulton County, which receives none of this money.

Noting that President Kennedy has handed the Defense Department the major responsibility for the nation's civil defense program, Mr. Hawksley said the federal government would pay half the salary of a full-time local director.

He suggested that without the Socialist Party ever gaining a national victory, most of its original program has come to pass under both major parties.

Much has been made of the fact that major Catholic institutions now guarantee firm tenure.

Rose Weiss, who handles all the prayer-requests that we receive, answering each letter personally, has the serene selflessness that comes from suffering: she has had many major operations, and now gets about in a limited way on braces and crutches.