* Infantile neuroaxonal dystrophy, a rare and severe neurological disorder which shows developmental regression in infants and toddlers

Pathological narcissism, defined as the libidinal investment in a pathological structure of the self, is further divided into three types ( regression to the regulation of the infantile self-esteem, narcissistic choice of object, narcissistic personality disorder ) with narcissistic personality disorder being the most severe of all.

It would be the most severe reprisal, short of declared war, that the United States could invoke against Castro.

The mid-term elections in 1862 brought the Republicans severe losses due to sharp disfavor with the administration over its failure to deliver a speedy end to the war, as well as rising inflation, new high taxes, rumors of corruption, the suspension of habeas corpus, the military draft law, and fears that freed slaves would undermine the labor market.

People who inhale an infectious aerosol would generally experience severe respiratory illness, including life-threatening pneumonia and systemic infection, if they are not treated.

A change in management and shortly after a change in club ownership led to severe problems, such as the reckless signing of former European Footballer of the Year Allan Simonsen, and the club looked like it would go out of business.

One reason was that higher status families were traditionally expected to be polyandrous to maintain wealth of the family ( one woman would marry and mate with many brothers in the same family ; this led to sexual competition within the family, severe tension, jealousy and conflicts ).

She would disgorge what she swallowed, and suffered severe stomach pains, which she bore with patience as another penance.

According to the Federal Reserve Bank of Minneapolis, " the Federal Reserve has the authority and financial resources to act as ' lender of last resort ' by extending credit to depository institutions or to other entities in unusual circumstances involving a national or regional emergency, where failure to obtain credit would have a severe adverse impact on the economy.

His final years were troubled by illnesses, some relating to obesity and what often is described as dropsy, severe edema that would be described today as congestive heart failure.

He concluded that a severe backlash against suspected Catholics would have followed, and that without foreign assistance a successful rebellion would have been unlikely ; despite differing religious convictions, most Englishmen were loyal to the institution of the monarchy.

In 1939, the Polish government rejected the German offer of forming an alliance on terms which would amount to an end or severe curtailment of Poland's sovereignty ; Hitler abrogated the Polish-German pact.

Primary pathogens may also cause more severe disease in a host with depressed resistance than would normally occur in an immunosufficient host.

Marx believed that increasingly severe crises would punctuate this cycle of growth, collapse, and more growth.

In 1612, Galileo Galilei proposed that with sufficiently accurate knowledge of the orbits of the moons of Jupiter one could use their positions as a universal clock and this would make possible the determination of longitude, but the practical problems of the method he devised were severe and it was never used at sea.

* As of 2012, most implementations of LCD backlighting use PWM to dim the display, which makes the screen flicker more acutely ( this does not mean visibly ) than a CRT monitor at 85 Hz refresh rate would ( this is because the entire screen is strobing on and off rather than a CRT's phosphor sustained dot which continually scans across the display, leaving some part of the display always lit ), causing severe eye-strain for some people.

On neurological examination, the weakness demonstrated with normal testing of power is often less severe than would be expected on the basis of the symptoms.

In 1959, a severe alcohol related car crash nearly cost Van Cleef his career as a resulting knee injury had doctors telling him he would never ride a horse again.

Their primary role was assisting the army with fortification duties and digging anti-tank ditches, but would as the shortage of manpower became severe be used as front line infantry, most often in urban settings.

It is theorized that detonating large numbers of nuclear weapons has a profound and severe effect on the climate causing cold weather and reduced sunlight for a period of months or even years, especially over flammable targets such as cities, where large amounts of smoke and soot would be ejected into the Earth's stratosphere.

" An important implication of their work was that a " first strike " nuclear attack would have severe consequences for the perpetrator.

However, a 1988 article by Brian Martin in Science and Public Policy states that although their paper concluded the effects would be less severe than originally thought, with the authors describing these effects as a " nuclear autumn ", other statements by Thompson and Schneider show that they " resisted the interpretation that this means a rejection of the basic points made about nuclear winter ".

Although ten years of exile would have been difficult for an Athenian to face, it was relatively mild in comparison to the kind of sentences inflicted by courts ; when dealing with politicians held to be acting against the interests of the people, Athenian juries could inflict very severe penalties such as death, unpayably large fines, confiscation of property, permanent exile and loss of citizens ' rights through atimia.

The dust layer would also likely cause severe maneuvering problems for rovers.

In " High Treason " the protagonist disobeys orders and betrays his subordinates to prevent a war crime that would bring severe retribution upon Humanity.

Confronted with this situation, most libraries either endure the severe limitations of their budgets and do what they can with what they have, or else depend on the bounty of patrons and local governments to supplement their annual funds.

Although Camus's approach in the book is severe, his narrator emphasizes the ideas that we ultimately have no control, and irrationality of life is inevitable.

In a small study published in 1995, the opioid buprenorphine was shown to have potential for treating severe, treatment-resistant depression.

There is some evidence to suggest that mirtazapine and venlafaxine may have greater efficacy than other antidepressants in the treatment of severe depression.

Many experts consider these drugs obsolete for treating anxiety but valuable for the short-term treatment of severe insomnia, though only after benzodiazepines or non-benzodiazepines have failed.

Long-term trials have shown continued effectiveness without the development of tolerance, and, in addition, unlike benzodiazepines, it does not disrupt sleep architecture and produces less severe cognitive and psychomotor impairment ; it also has a low potential for abuse and dependence and may be preferred over the benzodiazepines for these reasons.

Only when the side-effects have become too severe and / or a patient has been symptom-free for a long period of time is discontinuation carefully attempted.

Individuals who have had multiple withdrawal episodes are more likely to develop seizures and experience more severe anxiety during withdrawal from alcohol than alcohol dependent individuals without a history of past alcohol withdrawal episodes.

The southern and western parts of the country have a Mediterranean climate while inland areas and areas with high elevation experience short, cool summers and long, severe winters.

Under current United States law, bio-agents which have been declared by the U. S. Department of Health and Human Services or the U. S. Department of Agriculture to have the " potential to pose a severe threat to public health and safety " are officially defined as " select agents ".

Recently, two children born with severe combined immunodeficiency disorder (" SCID ") were reported to have been cured after being given genetically engineered cells.

Lamotrigine has been shown to have some efficacy in treating bipolar depression, and this benefit is greatest in more severe depression.

Benzodiazepines have a reputation with patients and doctors for causing a severe and traumatic withdrawal ; however, this is in large part due to the withdrawal process's being poorly managed.

High elevations have cold winters and short cool summers ; interior regions are subject to great temperature variability and severe droughts.

The economic achievements of Cyprus during the preceding decades have been significant, bearing in mind the severe economic and social dislocation created by the Turkish invasion of 1974 and the continuing occupation of the northern part of the island by Turkey.

A doctor attending a severe case in New Hampshire is said to have witnessed her healing one of his patients and asked if she could explain her system.

Her death certificate gives the cause of death as phthisis ( tuberculosis ), but many biographers suggest she may have died from dehydration and malnourishment, caused by excessive vomiting from severe morning sickness or hyperemesis gravidarum.

Judaism faced some severe restrictions under Constantius, who seems to have followed an anti-Jewish policy in line with that of his father.

Researchers have also identified another genetic variant, HLA-A * 3101 which has been shown to be a strong predictor of both mild and severe adverse reactions to carbamazepine among Japanese and Europeans.

Second, his hearing problems, which had already appeared earlier, had at the time become severe enough for him to have difficulties listening to his teachers talking.

It occurs as a consequence of a rapid rise in serum tonicity following treatment in individuals with chronic, severe hyponatraemia who have made intracellular adaptations to the prevailing hypotonicity.

An English family with a severe, heritable language dysfunction was found to have a defective copy of this gene.