The Man with the Golden Arm ( 1955 ) broke new ground with its exploration of the then taboo subject of heroin addiction, as did Anatomy of a Murder with its frank courtroom discussions of rape and sexual intercourse — the censors objected to the use of words such as " rape ", " sperm ", " sexual climax " and " penetration ".

The first stage is the penetration of corona radiata, by releasing hyaluronidase from the acrosome to digest cumulus cells surrounding the oocyte and exposing acrosin attached to the inner membrane of the sperm.

It also has an effect on cervical mucus quality and uterine mucosa, which might affect sperm penetration and survival, hence its early administration during the menstrual cycle.

The sperm's mitochondria are left behind as the sperm enters and drives through the coat ; this translocation of the mitochondria might provide the necessary force for penetration.

This type of motility may aid in sperm penetration of the zona pellucida, which encloses the ovum.

The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum.

A secondary mechanism of action is inhibition of sperm penetration by changes in the cervical mucus.

Coming from Sicily, one of the most traditional and old-fashioned parts of Italy, Panarello's book created a scandal because she writes about penetration, sperm, and orgasm in a very matter-of-fact fashion.

The endometrium becomes decidualized with atrophy of the glands .< sup > 65 </ sup > The progestin IUD probably has two mechanisms of action: inhibition of implantation and inhibition of sperm capacitation, penetration, and survival .</ ref > The levonorgestrel intrauterine system has several contraceptive effects:

* Very-low-dose progestogen-only contraceptives, such as traditional progestogen-only pills ( and subdermal implants Norplant and Jadelle and intrauterine systems Progestasert and Mirena ), inconsistently inhibit ovulation in ~ 50 % of cycles and rely mainly on their progestogenic effect of thickening the cervical mucus, thereby reducing sperm viability and penetration.

The embryonic period in humans begins at fertilization ( penetration of the egg by the sperm ) and continues until the end of the 10th week of gestation ( 8th week by embryonic age ).

At the pointed end are, as with other Demoiselles also a hole structure ( Mikropylenapparat ) with four holes to enable penetration of the sperm of the male.

The sperm chromatin dispersion test ( SCD ) and TUNEL assay are both effective in detecting sperm DNA damage.

This suborder also includes the sperm whale, killer whale, pilot whale, and beluga whale.

In most species, the sperm duct includes two or three spiny structures that presumably aid in copulation, although the details are unknown.

The first version consists of two acts of fifteen scenes and includes a dream sequence in which Irma's dream of three wounded young men — who personify blood, tears, and sperm — is enacted immediately before Arthur returns to the brothel and is shot abruptly.

The mechanism of action includes blocking the conversion of vitamin A into its active form retinoic acid which binds to retinoic receptors which is needed to initiate sperm production.

The second process in sperm activation is the acrosome reaction.

This involves releasing the contents of the acrosome, which disperse, and the exposure of enzymes attached to the inner acrosomal membrane of the sperm.

There is some evidence that this binding is what triggers the acrosome to release the enzymes that allow the sperm to fuse with the egg.

The acrosome is an organelle that develops over the anterior half of the head in the spermatozoa ( sperm cells ) of many animals.

This shedding of the acrosome or acrosome reaction can be stimulated in vitro by substances a sperm cell may encounter naturally such as progesterone or follicular fluid, as well as the more commonly used calcium ionophore A23187.

This can be done to serve as a positive control when assessing the acrosome reaction of a sperm sample by flow cytometry or fluorescence microscopy.

In the case of globozoospermia ( sperm with round heads ), the Golgi apparatus is not transformed into the acrosome, causing male infertility.

These spermatids differentiate morphologically into sperm by nuclear condensation, ejection of the cytoplasm and formation of the acrosome and flagellum.

Therefore sperm cells go through a process known as the acrosome reaction which is the reaction that occurs in the acrosome of the sperm as it approaches the egg.

As the sperm approaches the zona pellucida of the egg, which is necessary for initiating the acrosome reaction, the membrane surrounding the acrosome fuses with the plasma membrane of the oocyte, exposing the contents of the acrosome.

There is some evidence that this binding is what triggers the acrosome to release the enzymes that allow the sperm to fuse with the egg.

One should however bear in mind that a certain percentage of sperm cells will undergo a spontaneous acrosome reaction without the presence of the ovum.

When using intracytoplasmic sperm injection ( ICSI ) for IVF, the implantation rate is higher in oocytes injected with spermatozoa that have undergone acrosome reaction (~ 40 %) vs. those injected with nonreacted spermatozoa (~ 10 %).

The acrosome reaction can be stimulated in vitro by substances a sperm cell may encounter naturally such as progesterone or follicular fluid, as well as the more commonly used calcium ionophore A23187.

Birefringence microscopy, flow cytometry or fluorescence microscopy can be used for assessing the shedding of the acrosome or " acrosome reaction " of a sperm sample.

* Cortical reaction, occurs when a sperm cell unites with the egg's plasma membrane, altering the zona pellucida which prevents other sperm from binding to and entering the egg

Exposure to a foreign body causes a sterile inflammatory reaction in the intrauterine environment that is toxic to sperm and ova and impairs implantation .< sup > 28, 29 </ sup > The production of cytotoxic peptides and activation of enzymes lead to inhibition of sperm motility, reduced sperm capacitation and survival, and increased phagocytosis of sperm .< sup > 30, 31 </ sup > The TCu380A causes an increase in copper ions, enzymes, prostaglandins, and white blood cells ( macrophages ) in uterine and tubal fluids ; these impair sperm function and prevent fertilization. p.

The acrosomal reaction does not begin until the sperm comes into contact with the oocyte's cumulus layer.

The acrosomal reaction normally takes place in the ampulla of the fallopian tube ( site of fertilization ) when the sperm penetrates the secondary oocyte.

After this capacitation the sperm must undergo activation involving the acrosome reaction.

Once this occurs, the sperm is capable of binding with the zona pellucida, and the acrosome reaction can occur.

The test is supposed to examine interaction between sperm and mucus of the cervix.

Karyotyping is not a requirement in either EU or the U. S. but some sperm banks choose to test donors as an extra service to the customer.

One test in rats ( 20 milligrams of the 80 % ethanol extract ) found that these reduced sperm count by more than half.