After this initial chemotherapeutic compound proved effective, others pursued similar lines of inquiry, but it was not until in 1928 that Alexander Fleming observed antibiosis against bacteria by a fungus of the genus Penicillium.

The so-called Weil conjectures were hugely influential from around 1950 ; they were later proved by Bernard Dwork, Alexander Grothendieck, Michael Artin, and Pierre Deligne, who completed the most difficult step in 1973.

Alexander proved to be enthusiastic about the Canadian wilderness, as well as a popular governor general with the Canadian people, and he would be the last non-Canadian-born governor general before the appointment of Adrienne Clarkson in 1999.

Their attempts to treat humans failed because of insufficient volumes of penicillin ( the first patient treated was Reserve Constable Albert Alexander ), but they proved it harmless and effective on mice.

Moreover the Hellanodikai, who manage the games at Olympia, decided that they were so: for when Alexander wished to contend in the games and had descended for this purpose into the arena, the Hellenes who were to run against him tried to exclude him, saying that the contest was not for Barbarians to contend in but for Hellenes: since however Alexander proved that he was of Argos, he was judged to be a Hellene, and when he entered the contest of the foot-race his lot came out with that of the first.

The attack against Egypt of the Ptolemies proved a fiasco, and the generals sent against Molon and Alexander met with disaster.

The case of the initially " unidentified man ", commonly known as " Body 115 " after its mortuary tag number, was finally solved on 22 January 2004, when forensic evidence proved that he was 73-year-old Alexander Fallon of Falkirk, Scotland.

In the earlier sculpture show, this trick proved impossible for one piece, an Alexander Calder mobile whose wire inevitably hung at a true plumb vertical, " suggesting hallucination " in the disorienting context of the tilted floor.

Despite fervent support for the Greek cause in Russian nationalist circles, Alexander proved unwilling to defy Metternich and Castlereagh and offer the Greeks more than ( limited ) diplomatic support.

After Hunt ’ s death, his son Alexander and Brinley Sleight took over, publishing the newspaper daily, though this business model proved unsuccessful and the paper reverted back to a weekly publication.

Both efforts proved fruitless, and though Alexander agreed to his grandmother's wishes, he remained respectful of his father's position as immediate successor to the Russian throne.

The first of the Weil conjectures was proved by Bernard Dwork, and a completely different proof of the first two conjectures via l-adic cohomology was given by Alexander Grothendieck.

It proved to be very influential throughout Protestantism and Anabaptism, inspiring Anglican priest John Wesley to begin the Methodist movement and Alexander Mack to begin the Brethren movement.

When Saladin learned the truth from a letter Alexander found that proved Alhazred's treachery, he immediately sided with Alexander as did the rest of the castle guards.

The issue of violence proved an insurmountable barrier to unity between the SLP and the anarchist movement, however, and as Paul Grottkau, Alexander Jonas, and their co-thinkers began to again forcefully espouse the Marxist point of view in 1884, the SLP began to rebound.

Alexander seems to have died about 242 BC, leaving his country under the regency of his wife Olympias who proved anxious to have good relations with Epirus ' powerful neighbour, as was sanctioned by the marriage between the regent's daughter Phthia and Antigonus ' son and heir Demetrius.

While the rest of Longstreet's corps was located around Suffolk, Virginia, Alexander accompanied Stonewall Jackson on his flanking march at the Battle of Chancellorsville in May 1863, and his artillery placements in Hazel Grove at Chancellorsville proved decisive.

But this second period of Persian rule proved to be nearly as short as the first, and the islands became part of the rapidly growing Macedonian Empire as Alexander the Great swept through and defeated the Persians in 332 BC, to the great relief of the islands ' inhabitants.

The army proved true to the governor-general's earlier proclamation rather than to his later fears ; the hostages were rescued, the scene of Sir Alexander Burnes's murder in the heart of Kabul was burned down.

After Odoardo's death, Pope Alexander VII allowed Queen Christina of Sweden to lodge in the palace for several months, but she " proved a tenant from hell ".

The London County Council's resident engineer, Sir Alexander Binnie, submitted a design for a steel bridge, which proved unpopular.

Eventually Elagabalus and his mother Julia Soaemias proved incompetent rulers and favour fell on Alexander, Julia's son.

After the Games, which proved a success, Vikelas withdrew from the IOC, replaced as a member by the Count Alexander Mercati and as president by Coubertin.

His ideal was Alexander of Macedon, as Napoleon's was Julius Caesar.

Alexander guessed that they had planned confusion and turmoil, thinking it the ideal climate in which to begin battle and bloodshed.

Harding also made political speeches on the Chautauqua circuit and expressed admiration for his ideal American patron, Alexander Hamilton.

Most of the feuding Greek city-states were, in some scholars ' opinions, united under the banner of Philip's and Alexander the Great's pan-Hellenic ideals, though others might generally opt, rather, for an explanation of " Macedonian conquest for the sake of conquest " or at least conquest for the sake of riches, glory and power and view the " ideal " as useful propaganda directed towards the city-states.

The company decided that which comprised the original town site and belonged to Alexander Snow of Lanark would be an ideal location.

The concept of a grid being the ideal method of town-planning became widely accepted by the time of Alexander the Great.

In the late 13th century, a chronicle was compiled called the Life of Alexander Nevsky ( Житие Александра Невского ), in which he is depicted as an ideal prince-soldier and defender of Russia.

Alexander was also an idealist, but his ideals were apt to centre in himself ; his dislike and distrust of talents that overshadowed his own were disarmed for a while by the singular charm of Speransky's personality, but sooner or later he was bound to discover that he himself was regarded as but the most potent instrument for the attainment of that ideal end, a regenerated Russia, which was his minister's sole preoccupation.

In his review, Alexander Woollcott singled out Lawrence, calling her " the personification of style and sophistication " and " the ideal star.

Just from the pursuit of an ideal " classic " placed out of time, he creates difficulty in dating the Baptistery, similar to what occurs for other italian medieval monuments of strong classical style, like the church of St. Alexander in Lucca or the Basilica of St. Salvatore in Spoleto with the nearby Temple of Clitumnus.

Both in his work as a censor and in his writings he promoted the ideal of freedom of expression, frequently incurring the wrath of his superiors as a result even under the more relaxed regime of Alexander II.

Although the emancipation reform was commemorated by the construction of the enormous Alexander Nevsky Cathedral in Moscow and history books give Alexander II the name of " The Tsar Liberator ", its results were far from ideal.

If the number of generators, r, is less than or equal to the number of relations, s, then we consider the ideal generated by all r by r minors of the matrix ; this is the zero ' th Fitting ideal or Alexander ideal and does not depend on choice of presentation matrix.

If the Alexander ideal is principal, take a generator ; this is called an Alexander polynomial of the knot.

More generally if is a 3-manifold such that it has an Alexander polynomial defined as the order ideal of its infinite-cyclic covering space.

Since the Alexander ideal is principal, if and only if the commutator subgroup of the knot group is perfect ( i. e. equal to its own commutator subgroup ).

" Thus the romance would trace back the model of ideal civilization that it proposes, a model also for the orders of chivalry created from the 14th century onwards, to a legendary origin where the glory of Alexander is united with the fame of Arthur.

In issue # 6 of the Infinite Crisis mini-series, a now anti-heroic Superboy-Prime convinced Alexander Luthor that Earth-Prime was the ideal world and urged him to draw his inspiration for making a new Earth from Earth-Prime.