Although single genes have little effect on complex traits and interact heavily both between themselves and with the external factors, research is underway to unravel possible molecular mechanisms underlying anxiety and comorbid conditions.

Although the hardware is limited to four separate sound channels, software such as OctaMED uses software mixing to allow eight or more virtual channels, and it was possible for software to mix two hardware channels to achieve a single 14-bit resolution channel by playing with the volumes of the channels in such a way that one of the source channels contributes the most significant bits and the other the least.

Although " Takes A Little Time " was a moderate hit single, the album failed to sell like the previous two albums, which had both gone multi-platinum.

Although BR was a single entity, it was divided into six ( later five ) regional authorities in accordance with the existing areas of operation.

Although his success lasted only a year and a half before his death in an airplane crash, Holly is described by critic Bruce Eder as " the single most influential creative force in early rock and roll.

Although there is no strong evidence for any single theory, many independent theories exist, some blaming storms, some capsizing, and some suggesting that wartime enemy activity was to blame for the loss.

" Although based on a simplistic analysis of internal strife in Greece and Turkey, it became the single dominating influence over U. S. policy until at least the Vietnam War.

Although some say Judaism is noncreedal in nature, others say it recognizes a single creed, the Shema Yisrael, which begins: " Hear, O Israel: the LORD our God, the LORD is one.

Although the two parts are now normally published as a single work, Don Quixote, Part Two was a sequel published ten years after the original novel.

Although bacteriophages were first described in 1927, it was only in 1959 that Sinshemer working with phage Phi X 174 showed that they could possess single stranded DNA genomes.

Although the track was edited out of the final cut, it would later be re-recorded and released as " Safe " on the B-side of Bowie's 2002 single " Everyone Says ' Hi '".

Although the single sold poorly, the popularity of Jones's appearance on the show resulted in " Girl " becoming his best remembered solo hit, even though it was not included in the album.

Although many of the results in Elements originated with earlier mathematicians, one of Euclid's accomplishments was to present them in a single, logically coherent framework, making it easy to use and easy to reference, including a system of rigorous mathematical proofs that remains the basis of mathematics 23 centuries later.

Although it never uses the term, The Church of Jesus Christ of Latter-day Saints ( The Mormon Church ) is episcopal, rather than presbyterian or congregational, in the sense that it has a strict hierarchy of leadership from the local bishop up to a single prophet / president, believed to be personally authorized and guided by Jesus Christ.

Although there are important differences between them, all of them were materialists who believed that the world was made up of a single substance, matter, the motions and properties of which could be used to explain all phenomena.

Although its file format also allows for multiple such streams to be concatenated ( zipped files are simply decompressed concatenated as if they were originally one file ), gzip is normally used to compress just single files.

Although turret presses operate much like single stage presses, they eliminate much of the setup time required in positioning individual dies correctly.

" Although it was a single sentence in a 461-page book, reviewers focused on it.

Although the school was a single institution, it was divided into two parts: a grammar school called the collège or schola privata and an advanced school called the académie or schola publica.

Although a single EPSP was not enough to fire an action potential in the motor neuron, the sum of several EPSPs from multiple sensory neurons synapsing onto the motor neuron could cause the motor neuron to fire, thus contracting the quadriceps.

Although he is often characterized as an " architect " exclusively, as James Beck has observed, " to single out one of Leon Battista's ' fields ' over others as somehow functionally independent and self-sufficient is of no help at all to any effort to characterize Alberti's extensive explorations in the fine arts.

Although they reign under constitutions, the monarchs of Brunei, Oman, Qatar, Saudi Arabia and Swaziland appear to continue to exercise more political influence than any other single source of authority in their nations, either by constitutional mandate or by tradition.

Although the term " metallic bond " is often used in contrast to the term " covalent bond ", it is preferable to use the term metallic bonding, because this type of bonding is collective in nature and a single " metallic bond " does not exist.

Although four songs were released as singles to promote the album ( lead single " Everything I Need ", " Man With Two Hearts ", " Maria ", and " Hard Luck Story "), only the first song charted in the US, and that only at No. 47.

Although they do share commonalities, contemporary Pagan religious movements are diverse and no single set of beliefs, practices, or texts are shared by them all.

Although many of their remixes for other artists have been successful club hits, they did not return to the chart as artists until 2002, when " I'll Be Waiting " featuring Shena climbed to number three.

Although New Orleans was not to learn of it for a spell, she also was a sadist, a nymphomaniac and unobtrusively mad -- the perpetrator of some of the worst crimes against humanity ever committed on American soil.

Although he is perfectly willing to cooperate with Scotland Yard, Holmes has nothing but contempt for the intelligence and mentality of the police.

Although his tender nights were not the ones I dreamed of, nor was it for yachts, sports cars, tall drinks, and swimming pools, nor yet for money or what money buys that I burned, I too was burning and watching myself burn.

Although it does not follow the metrical rules for a blues to be sung, the phrases themselves carry a blues feeling.

Although the laws of the various states, in general, specify the situs of property, i.e., residence or domicile of the owner, or location of the property, the exceptions regarding boats, airplanes, mobile homes, etc., seem to add to the uncertainty of the proper origination point for assessment.

Although a similar situs for tangible property is mentioned in the statute, this is cancelled out by the provision that definite kinds of property `` and all other tangible property '' situated or being in any town is taxable where the property is situated.

Although there are many sound reasons for adopting uniform and coordinated fiscal years in Rhode Island, there are also certain difficulties encountered.

Although the need for outside trained manpower exists in every newly developing nation, the readiness to receive such manpower, or to receive it from the United States will vary from country to country.

Although Mr. Brown was not himself its inventor ( it was a French idea ), it is typical that his intuition first conceived the importance of mass producing this basic tool for general use.

Although the impact of these increases on our industry's shipments will be gradual, on balance I look for another good increase in shipments in the coming year, to at least $6 billion.

Although lacking absolute verisimilitude, they supply the ear and the imagination with all necessary materials for re-creation of the original.

Although the tape was run for over 1 hr., a steady state was not reached, and it was concluded that the reason for this was that the back pressure of the manometer was built up from the material fed from between the blocks and this was available at a very slow rate.

Although the Af calculation is obvious by analogy with that for gravitational field and osmotic pressure, it is interesting to confirm it by a method which can be generalized to include related effects.

-- Although there was some variation in results which must be attributed either to trace impurities or to variation in wall effects, the photochemical exchange in the gas phase was sufficiently reproducible so that it seemed meaningful to compare the reaction rates in different series of reaction tubes for the purpose of obtaining information on the effect of chlorine concentration and of carbon tetrachloride concentration on the reaction rate.

Although the standard deviation values on which spread of the lines is based are relatively larger for those centers which begin to ossify early ( Table 1 ), there are considerable differences in this value between centers having the closely timed Onsets.

Although biopsies have shown structural changes in some of the reported cases of steroid-induced weakness, this case provides the only example known to us in which necropsy afforded the opportunity for extensive study of multiple muscle groups.

Although we are still far from a complete understanding of these problems, as a first approximation, it is suggested that alterations in the hypothalamic balance with consequent changes in the hypothalamic-cortical discharges account for major changes in behavior seen in various moods and states of emotions in man and beast under physiological circumstances, in experimental and clinical neurosis, and as the result of psychopharmacological agents.

Although the government was probably prepared for elections by mid-1958, the first decision was no doubt made more difficult as party strife multiplied.

Although the elections were for local officials, it was not necessary to conduct the elections so as to prevent parties from publicly identifying their candidates.

Although it is in some ways comparable to a voluntary sale of assets for cash, to which section 203 quite clearly applies, the courts and Treasury have held that acquiring corporations in several types of non-taxable reorganizations may sue for refund of taxes paid by transferors.

Although no national norms exist for the social development of children, the teacher can find a great deal of information concerning types of social behavior normally displayed by children at various age levels.

Although wanted by the sheriff for killing an old man named Asher Jones, the warrant for his arrest had never been served.