Although single genes have little effect on complex traits and interact heavily both between themselves and with the external factors, research is underway to unravel possible molecular mechanisms underlying anxiety and comorbid conditions.

Although the hardware is limited to four separate sound channels, software such as OctaMED uses software mixing to allow eight or more virtual channels, and it was possible for software to mix two hardware channels to achieve a single 14-bit resolution channel by playing with the volumes of the channels in such a way that one of the source channels contributes the most significant bits and the other the least.

Although " Takes A Little Time " was a moderate hit single, the album failed to sell like the previous two albums, which had both gone multi-platinum.

Although BR was a single entity, it was divided into six ( later five ) regional authorities in accordance with the existing areas of operation.

Although his success lasted only a year and a half before his death in an airplane crash, Holly is described by critic Bruce Eder as " the single most influential creative force in early rock and roll.

Although there is no strong evidence for any single theory, many independent theories exist, some blaming storms, some capsizing, and some suggesting that wartime enemy activity was to blame for the loss.

" Although based on a simplistic analysis of internal strife in Greece and Turkey, it became the single dominating influence over U. S. policy until at least the Vietnam War.

Although some say Judaism is noncreedal in nature, others say it recognizes a single creed, the Shema Yisrael, which begins: " Hear, O Israel: the LORD our God, the LORD is one.

Although the two parts are now normally published as a single work, Don Quixote, Part Two was a sequel published ten years after the original novel.

Although bacteriophages were first described in 1927, it was only in 1959 that Sinshemer working with phage Phi X 174 showed that they could possess single stranded DNA genomes.

Although the track was edited out of the final cut, it would later be re-recorded and released as " Safe " on the B-side of Bowie's 2002 single " Everyone Says ' Hi '".

Although the single sold poorly, the popularity of Jones's appearance on the show resulted in " Girl " becoming his best remembered solo hit, even though it was not included in the album.

Although many of the results in Elements originated with earlier mathematicians, one of Euclid's accomplishments was to present them in a single, logically coherent framework, making it easy to use and easy to reference, including a system of rigorous mathematical proofs that remains the basis of mathematics 23 centuries later.

Although it never uses the term, The Church of Jesus Christ of Latter-day Saints ( The Mormon Church ) is episcopal, rather than presbyterian or congregational, in the sense that it has a strict hierarchy of leadership from the local bishop up to a single prophet / president, believed to be personally authorized and guided by Jesus Christ.

Although there are important differences between them, all of them were materialists who believed that the world was made up of a single substance, matter, the motions and properties of which could be used to explain all phenomena.

Although its file format also allows for multiple such streams to be concatenated ( zipped files are simply decompressed concatenated as if they were originally one file ), gzip is normally used to compress just single files.

Although turret presses operate much like single stage presses, they eliminate much of the setup time required in positioning individual dies correctly.

" Although it was a single sentence in a 461-page book, reviewers focused on it.

Although the school was a single institution, it was divided into two parts: a grammar school called the collège or schola privata and an advanced school called the académie or schola publica.

Although a single EPSP was not enough to fire an action potential in the motor neuron, the sum of several EPSPs from multiple sensory neurons synapsing onto the motor neuron could cause the motor neuron to fire, thus contracting the quadriceps.

Although he is often characterized as an " architect " exclusively, as James Beck has observed, " to single out one of Leon Battista's ' fields ' over others as somehow functionally independent and self-sufficient is of no help at all to any effort to characterize Alberti's extensive explorations in the fine arts.

Although they reign under constitutions, the monarchs of Brunei, Oman, Qatar, Saudi Arabia and Swaziland appear to continue to exercise more political influence than any other single source of authority in their nations, either by constitutional mandate or by tradition.

Although the term " metallic bond " is often used in contrast to the term " covalent bond ", it is preferable to use the term metallic bonding, because this type of bonding is collective in nature and a single " metallic bond " does not exist.

Although four songs were released as singles to promote the album ( lead single " Everything I Need ", " Man With Two Hearts ", " Maria ", and " Hard Luck Story "), only the first song charted in the US, and that only at No. 47.

Although they do share commonalities, contemporary Pagan religious movements are diverse and no single set of beliefs, practices, or texts are shared by them all.

Although he described his method as translating " sometimes word for word, sometimes sense for sense ," Alfred's translation actually keeps very close to his original, although through his choice of language he blurred throughout the distinction between spiritual and secular authority.

Although the Bildungsroman arose in Germany, it has had extensive influence first in Europe and later throughout the world.

Although current trends show substantial competition from alternative interpretations, throughout much of the twentieth century the Copenhagen interpretation had strong acceptance among physicists.

Although Arab culture is firmly established throughout, a small minority are Christian.

Although his term lasted only six months instead of twelve ( except for the Dictatorships of Sulla and Caesar ), all other magistrates reported to the dictator ( except for the tribunes of the plebs-although they could not veto any of the dictator's acts ), granting the dictator absolute authority in both civil and military matters throughout the Republic.

Although these calls are made throughout the year, they are most common during the spring mating season and in the fall when the pups leave their families to establish new territories.

Although amounts vary with the location, rain is possible throughout the year, with the greatest monthly totals recorded from June through October.

Although various notations are used throughout the literature to denote that two elements a and b of a set are equivalent with respect to an equivalence relation R, the most common are " a ~ b " and " a ≡ b ", which are used when R is the obvious relation being referenced, and variations of " a ~< sub > R </ sub > b ", " a ≡< sub > R </ sub > b ", or " aRb ".

Although the Pentecostarion ends on the Sunday of All Saints, Pascha's influence continues throughout the following year, determining the daily Epistle and Gospel readings at the Divine Liturgy, the Tone of the Week, and the Matins Gospels all the way through to the next year's Lazarus Saturday.

Although many naturalists have studied aspects of animal behaviour throughout history, the modern discipline of ethology is generally considered to have begun during the 1930s with the work of Dutch biologist Nikolaas Tinbergen and Austrian biologists Konrad Lorenz and Karl von Frisch, joint winners of the 1973 Nobel Prize in Physiology or Medicine.

Although Scheler later criticised Husserl's idealistic logical approach and proposed instead a " phenomenology of love ", he states that he remained " deeply indebted " to Husserl throughout his work.

Although elves could be considered to be beautiful and potentially helpful beings in some sections of English-speaking society throughout its history, Old English evidence also attests to alignments of elves with demons, as for example in line 112 of Beowulf.

Although the emperor has been a symbol of continuity with the past, the degree of power exercised by the emperor of Japan has varied considerably throughout Japanese history.

Although the city was affected by the Great Depression and simultaneous drought, it nevertheless experienced slow and steady growth throughout the early part of the twentieth century.

Although semitisms exist throughout the Gospel of Luke, it was composed in Koine Greek.

Although the Sicherheitspolizei was officially disbanded, the term SiPo was figuratively used to describe any RSHA personnel throughout the remainder of the war.

Although " posterity has treated Maurice Evans less kindly ", throughout the 1930s and 1940s he was regarded by many as the leading interpreter of Shakespeare in the United States and in the 1938 / 9 season he presented Broadway's first uncut Hamlet, running four and a half hours.

Although Infocom started out with Zork, and although the Zork world was the centerpiece of their product line throughout the Zork and Enchanter series, the company quickly branched out into a wide variety of story lines: fantasy, science-fiction, mystery, horror, historical adventure, children's stories, and others that defied categories.

" Although throughout his book Camus is concerned to present " the rebel " as a preferred alternative to " the revolutionary " he nowhere acknowledges that this distinction is taken from the one that Stirner makes between " the revolutionary " and " the insurrectionist ".

Although nationalist movements throughout the colonial world led to the political independence of nearly all of the Asia's remaining colonies, decolonisation was intercepted by the Cold War ; and South East Asia, South Asia, the Middle East, and East Asia remained embedded in a world economic, financial, and military system in which the great powers compete to extend their influence.

Although many kinds of minerals were extracted throughout the country, most mineral resources had to be imported in the postwar era.

Although he was initially successful in starving out Britain, Portugal refused to capitulate, leading to the Peninsular War throughout Spain.

Although his parents did not officially divorce until 1999, their marriage was in serious trouble throughout Walker's adolescence ; his father would often leave their Marin residence for extended periods to live in San Francisco with a male lover.

Although famous throughout California for his association with the Gold Rush, Sutter died almost poor, having seen his business ventures fail while those of his elder son, John Augustus Sutter, Jr., were more successful.

Although his grandson, Louis Pasteur Vallery-Radot, wrote that Pasteur had only kept from his Catholic background a spiritualism without religious practice, Catholic observers often said Louis Pasteur remained throughout his whole life an ardent Christian, and his son-in-law, in perhaps the most complete biography of Louis Pasteur, writes: