Although constitutively expressed proteasomes can participate in this process, a specialized complex composed of proteins whose expression is induced by interferon gamma produces peptides of the optimal size and composition for MHC binding.

Although the official restrictions only focus on the flatness and rigidness of the blade itself, these dimensions are optimal for most play styles.

Although the three-peg version has a simple recursive solution as outlined above, the optimal solution for the Tower of Hanoi problem with four pegs ( called Reve's puzzle ), let alone more pegs, is still an open problem.

Although opposition to the use of any transgenic technologies in organic farming is strong, agricultural researchers Luis Herrera-Estrella and Ariel Alvarez-Morales continue to advocate integration of transgenic technologies into organic farming as the optimal means to sustainable agriculture, particularly in the developing world.

Although the advent of modern refrigeration — including kimchi refrigerators specifically designed with precise controls to keep different varieties of kimchi at optimal temperatures at various stages of fermentation — has made this seasonality unnecessary, Koreans continue to consume kimchi according to traditional seasonal preferences.

Although there was still no aircraft capable of lifting these bombs to their optimal release altitude, these two bombs could still be dropped from a lower altitude, entering the earth at supersonic speed and penetrating to a depth of 20 metres before exploding.

Although the word " optimization " shares the same root as " optimal ", it is rare for the process of optimization to produce a truly optimal system.

Although it is the optimal symbol-by-symbol coding for such probability distributions, Golomb coding achieves better compression capability for the geometric distribution because it does not consider input symbols independently, but rather implicitly groups the inputs.

Although this will result in choosing the same action as would be chosen using the Bayes risk, the emphasis of the Bayesian approach is that one is only interested in choosing the optimal action under the actual observed data, whereas choosing the actual Bayes optimal decision rule, which is a function of all possible observations, is a much more difficult problem.

Although duckweed can tolerate temperatures ranging from 6 to 33 ° C, the optimal growth range is 20 to 28 ° C.

Although his algorithm is only slightly faster than the standard algorithm for matrix multiplication, he was the first to point out that the standard approach is not optimal.

Although wet acidic soils are optimal, the winterberry will grow well in the average garden.

Although this approach is not optimal, in practice it has given very good results.

Although selected trials showed no evidence proving the effectiveness of NDT as the optimal type of treatment, neither did they show evidence of non-efficacy because of methodological limitations.

Although upwelling and the subsequent high biological productivity produces optimal conditions for the growth of juvenile and adult sardines, the absence of strong upwelling in late winter and early spring ( such as that found in the California Bight ) is what creates optimum conditions for the survival of fish larvae ( Mann and Lazier, 2006 ).

Although it is not asymptotically optimal, Knuth concluded in 1998, with respect to the AKS network that " Batcher's method is much better, unless n exceeds the total memory capacity of all computers on earth!

Although ISOs have more favorable tax treatment than non-ISOs ( aka non-statutory stock option ( NSO ) or non-qualified stock option ( NQO )), they also require the holder to take on more risk by having to hold onto the stock for a longer period of time if the holder is to receive optimal tax treatment.

Although luck is involved and factors into the outcome, strategy plays a more important role in the long run.

Although no strategy can be applied to increase odds in such games, players may employ " lucky numbers " to find what they think will help them.

Although more fearsome than Bai Bureh's rising, it was amorphous, lacked a definite strategy, and was suppressed in most areas in two months.

Although relying solely on security through obscurity is almost always a very poor design decision, keeping secret some of the details of an otherwise well-engineered system may be a reasonable tactic as part of a defense in depth strategy.

Although it was late in the campaigning season when he had come to power, Pitt set about trying to initiate a more assertive strategy.

Although the extent-based nature of XFS and the delayed allocation strategy it uses significantly improves the file system's resistance to fragmentation problems, XFS provides a filesystem defragmentation utility (, short for XFS filesystem reorganizer ) that can defragment the files on a mounted and active XFS filesystem.

Although Bryan had decided on a strategy to gain the nomination — to give a speech which would make him the logical candidate in the eyes of delegates — he faced obstacles along the way.

Although z / OS customers vary in their maintenance practices, IBM encourages every z / OS customer to adopt a reasonable preventive maintenance strategy, to avoid known problems before they might occur.

Although Kurzweil agrees that by 2019 the current strategy of ever-finer photolithography will have run its course, he speculates that this does not mean the end of Moore's law:

Although Forrest lacked formal military education, he had a gift for strategy and tactics.

Although Nouvelle Résistance at first opposed the " national conservatives " of Jean-Marie Le Pen's National Front, it changed strategy, adopting the slogan " Less Leftism!

Although described by one critic as " the squarest music this side of Euclid ,", this strategy proved commercially successful and the show remained on the air for 31 years.

Although this strategy has been criticized for encouraging overwhelming force over strategy and tactics, defenders of the strategy argue that they're simply taking advantage of the strategies utilized, and some argue that it is a realistic representation of warfare.

Although the CIA in general and Charlie Wilson, a Texas Congressman, have received most of the attention, the key architect of this strategy was Michael G. Vickers, a young Paramilitary Officer.

Although he thought the strategy unwise, Vergennes continuously advocated war in Constantinople by trying to convince that Ottomans that war was the only way to check Russia's rising power.

Although the criterion argument applies to both deduction and induction, Weintraub believes that Sextus ' argument " is precisely the strategy Hume invokes against induction: it cannot be justified, because the purported justification, being inductive, is circular.

Although Titokowaru provided the strategy and leadership that had been missing among tribes that had fought in the Second Taranaki War and his forces never lost a battle during their intensive campaign, they mysteriously abandoned a strong position at Tauranga-ika Pā and Titokowaru's army immediately began to disperse.

Although there are different characteristic between Japanese and Christian churches, Ando treats them with the similar strategy.

Although this programming strategy was discontinued in the 1980s, it was reinstated on CITY and CKVU for short time in the early 2000s.

Although the rules are quite simple ( and were the simplest rules in the 2001 8x8 Game Design Competition ), the strategy is complex and sophisticated.

Although computers can play some abstract strategy games better than any human, the best Havannah-playing software to date plays quite weakly compared to human experts.

Although Magic: The Gathering is essentially a strategy game that uses decks of cards, an intricate storyline underlies the cards released in each expansion.

Although Doubleday achieved minor fame as a competent combat general with experience in many important Civil War battles, he is more widely remembered as the supposed inventor of the game of baseball, in Elihu Phinney's cow pasture in Cooperstown, New York, in 1839.

Although game reports and social reactions are common parts of many A & E contributions, it has also, over the years, become a testing ground for new ideas on the development of the RPG as a genre and an art form.

Although many board games have a jargon all their own, there is a generalized terminology to describe concepts applicable to basic game mechanics and attributes common to nearly all board games.

Although he manages to revive and finish the game, he dies next morning from internal bleeding in the skull, leaving his son an orphan.

Although player characters are substantially weaker than many of the dangers they face, the game is one of the first to encourage problem solving and outwitting obstacles, rather than out-fighting them.

Although newer systems have updated game mechanics significantly, the ideas presented in Bunnies & Burrows created the framework for modern role-playing games.

Although the game had " incredible role-playing potential ", the concept of role-playing rabbits can be viewed as bizarre, and as such at least one commentator believes that " most people thought it was stupid " when it was first released.

Although the Rutgers-Princeton game was undoubtedly different from what we today know as American football, it was the forerunner of what evolved into American football.

Although the college game has a much larger margin for talent than its pro counterpart, the sheer number of fans following major colleges provides a financial equalizer for the game, with Division I programs – the highest level – playing in huge stadiums, six of which have seating capacity exceeding 100, 000.

Although the phrase " perfect game " appeared in record books as early as 1922, and was a common expression years before that, Major League Baseball did not formalize the definition of a " perfect game " until 1991, long after Young's death.

Although the majority of WADs contain one or several custom levels mostly in the style of the original game, others implement new monsters and other resources, and heavily alter the gameplay ; several popular movies, television series, other video games and other brands from popular culture have been turned into Doom WADs by fans ( without authorization ), including Aliens, Star Wars, The X-Files, The Simpsons, South Park, Sailor Moon, Dragon Ball Z, Red Faction, The Thing, Pokémon and Batman.

Although the Fortune Deck works as a randomizer, the results obtained by it are entirely arbitrary and subjective, and the GM's absolute power over the game is further emphasized by the three resolution systems: Karma ( the higher character ability wins, modified by situation ), Drama ( the GM decides what happens, by what they think most appropriate ), and Fortune ( more or less the same as the above, with interpretation flavored by a card draw ).

In his history of the game, historian David Nelson concluded that the first forward passes were thrown on Christmas Day 1905 in a match between two small colleges in Kansas: " Although Cochems was the premier passing coach during the first year of the rule, the first forward passes were thrown at the end of the 1905 season in a game between Fairmount and Washburn colleges in Kansas.

< nowiki >* Although coin tossing isn't usually played in a casino, it has been known to be an official gambling game in some Australian casinos </ nowiki >

Although ABC does not air any national game shows, its syndication wing Disney-ABC Domestic Television distributes Who Wants to Be a Millionaire ?, and many of their local affiliates air it in syndication.

Although crowds singing anthems during matches was common place, there was no precedent for the anthem to be sung before a game commenced in any sport.

Although the white jerseys of the Minnesota Vikings at the time also had a similar striping pattern and continued as such ( as well as the throwbacks the New England Patriots wore in the Thanksgiving game against the Detroit Lions in 2002, though the Patriots later wore the same throwbacks in 2009 with truncated stripes and in 2010 became their official alternate uniform ), the Colts and most college teams with this striping pattern did not make this adjustment.

Although the first competition had separate sections for Inform and TADS games, subsequent competitions have not been divided into sections and are open to games produced by any method, provided that the software used to play the game is freely available.

Although this was its primary business for years, its place in videogame folklore was cemented by its ambitious and ultimately ill-fated plans to release its own video game console, the Konix Multisystem.

Although not entirely in the spirit of the game, an underarm delivery was quite legal, so long as the arm was kept straight.

Although the games existed in pockets in Europe -- it is recorded as being played as early as the 17th century by merchants in England -- it has never gained much popularity in most regions, except in the Baltic area, where once it was a very popular game (" Bohnenspiel ") and Bosnia, where it is called Ban-Ban and still played today.

Although these innovations are not all entirely new with Wadzinski, the book marks a significant advancement in published maze puzzles, offering expansions on the traditional puzzles that seem to have been fully informed by various video game innovations and designs, and adds new levels of challenge and complexity in both the design and the goals offered to the puzzle-solver in a printed format.