As a part of the 2011 Kallikratis government reform, the prefecture was abolished, and its territory was divided into 9 regional units of the South Aegean region:
As a part of the 2011 Kallikratis government reform, the regional unit Laconia was created out of the former prefecture Laconia ().
As a part of the 2011 Kallikratis government reform, the regional unit Ithaca was created out of part of the former Kefalonia and Ithaca Prefecture.
As a part of the 2011 Kallikratis government reform, the regional unit Thasos was created out of part of the former Kavala Prefecture.
As a part of the 2011 Kallikratis government reform, the regional unit Achaea was created out of the former prefecture Achaea ().
As a part of the 2011 Kallikratis government reform, the regional unit Pella was created out of the former prefecture Pella ().
As a part of the 2011 Kallikratis government reform, the regional unit Andros was created out of part of the former Cyclades Prefecture.
As a part of the 2011 Kallikratis government reform, the regional unit Arta was created out of the former prefecture Arta.
As a part of the 2011 Kallikratis government reform, the regional unit Florina was created out of the former prefecture Florina.
As a part of the 2011 Kallikratis government reform, the regional unit Zakynthos was created out of the former prefecture Zakynthos ().
As a part of the 2011 Kallikratis government reform, the prefecture was split into the Magnesia and Sporades regional units.
As a part of the 2011 Kallikratis government reform, the regional unit Lasithi was created out of the former prefecture of Lasithi (), which was created while Crete was still an autonomous state and was retained after the island joined Greece in 1913.
As a part of the 2011 Kallikratis government reform, the regional unit Sporades was created out of part of the former Magnesia Prefecture.
As a part of the 2011 Kallikratis government reform, the former Kilkis Prefecture () was transformed into a regional unit within the Central Macedonia region, without any change in boundaries.
As a part of the 2011 Kallikratis government reform, the regional unit Aetolia-Acarnania was created out of the former prefecture Aetolia-Acarnania ().
As a part of the 2011 Kallikratis government reform, the regional unit Argolis was created out of the former prefecture Argolis ().
As a part of the 2011 Kallikratis government reform, the regional unit Evrytania was created out of the former prefecture Evrytania ().
As a part of the 2011 Kallikratis government reform, the prefecture was transformed into a regional unit within the East Macedonia and Thrace region, with no change in its boundaries.
As a part of the 2011 Kallikratis government reform, the regional unit Phthiotis was created out of the former prefecture Phthiotis ().
As a part of the 2011 Kallikratis government reform, the regional unit Karditsa was created out of the former prefecture Karditsa.
As a part of the 2011 Kallikratis government reform, the regional unit Chalkidiki was created out of the former prefecture Chalkidiki ().
As a part of the 2011 Kallikratis government reform, the regional unit Pieria was created out of the former prefecture Pieria ().
As a part of the 2011 Kallikratis government reform, the prefecture was transformed into a regional unit within the East Macedonia and Thrace region, with no change in its boundaries.
As a part of the 2011 Kallikratis government reform, the regional unit Thesprotia was created out of the former prefecture Thesprotia.
As a part of the 2011 Kallikratis government reform, the regional unit Tinos was created out of part of the former Cyclades Prefecture.
As a part of the 2011 Kallikratis government reform, the regional unit Corinthia was created out of the former prefecture Corinthia ().
As a part of the 2011 Kallikratis government reform, the prefecture was transformed into a regional unit within the Central Macedonia region, without any change in boundaries.
As a part of the 2011 Kallikratis government reform, the Serres regional unit was created out of the former Serres Prefecture ().
As a part of the 2011 Kallikratis government reform, the former Drama Prefecture () was transformed into a regional unit within the East Macedonia and Thrace region.
As a part of the 2011 Kallikratis government reform, the former Kavala Prefecture () was transformed into a regional unit within the East Macedonia and Thrace region.
As a part of the 2011 Kallikratis government reform, the Chania regional unit was created out of the former prefecture.
As a part of the 2011 Kallikratis government reform, the regional unit Ioannina was created out of the former prefecture Ioannina.
As a part of the 2011 Kallikratis government reform, the regional unit Larissa was created out of the former prefecture Larissa.
As a part of the 2011 Kallikratis government reform, the regional unit Trikala was created out of the former prefecture Trikala.
As a part of the 2011 Kallikratis government reform, the Rethymno regional unit was created out of the former prefecture.
As a part of the 2011 Kallikratis government reform, the regional unit Grevena was created out of the former prefecture Grevena.
As a part of the 2011 Kallikratis government reform, the regional unit Kastoria was created out of the former prefecture Kastoria.
As a part of the 2011 Kallikratis government reform, the regional unit Kozani was created out of the former prefecture Kozani.
As a part of the 2011 Kallikratis government reform, the regional unit Preveza was created out of the former prefecture Preveza.
As a part of the 2011 Kallikratis government reform, the prefecture was transformed into a regional unit within the East Macedonia and Thrace region, with no change in its boundaries.
As a part of the 2011 Kallikratis government reform, the regional unit Heraklion was created out of the former prefecture Heraklion.
As a part of the 2011 Kallikratis government reform, the former Euboea Prefecture () was transformed into a regional unit within the Central Greece region, without any change in boundaries.
As a part of the 2011 Kallikratis government reform, the regional unit Corfu was created out of the former prefecture Corfu ().
As a part of the 2011 Kallikratis government reform, the regional unit Lefkada was created out of the former prefecture Lefkada ().
As a part of the 2011 Kallikratis government reform, the regional unit Chios was created out of the former prefecture Chios ().
As a part of the 2011 Kallikratis government reform, the regional unit Lesbos was created out of part of the former Lesbos Prefecture.
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