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Azapirones and are
Azapirones are a class of drugs used as anxiolytics and antipsychotics
.
Azapirones are poorly but nonetheless appreciably absorbed and have
a rapid onset
of action, but have only very short half-lives ranging from 1 – 3 hours
.
Azapirones and .
Azapirones have more tolerable adverse effects than many other available anxiolytics like the benzodiazepines
.
are and class

Class 2, stations operating on clear channels
are required to cease operation or operate under nighttime restrictions beginning either at local sunset ( for daytime
class 2, stations ) or sunset at the location
of the dominant
class 1, station where located west
of the
class 2, station ( for limited-time
class 2, stations )
.

The same restrictions apply after local sunset in the case
of class 3, stations operating on regional channels, which after that time
are required to operate under nighttime restrictions in order to protect each other
.

The
class 1, stations on these clear channels
are protected to their 0.1-mv./m. groundwave contours against daytime cochannel interference
.

With respect to skywave service rendered at night,
class 1, -- A stations
are the only stations permitted to operate in the United States on clear channels specified for
class 1, -- A operation, and so render skywave service free from cochannel interference whereever they may be received ; ;
class 1, -- B stations
are protected at night to their 0.5-mv./m. 50-percent time skywave contours against cochannel interference
.

Since the provision
of skywave service requires adequate freedom from interference, only
class 1, stations
are capable
of rendering skywave service
.

With respect to other frequencies, these
are designated as regional or local, and assigned for use by
class 3, and
class 4, stations, respectively, stations operating generally with lower power
.

On the remainder
of the clear channels, the dominant (
class 1 ) -- B stations
are protected as described above, and the relatively small number
of secondary (
class 2 ) ) stations permitted to operate on these channels at night
are required to operate directionally and/or with reduced power so as to protect the
class 1, stations
.

Such additional daytime
class 2, assignments
are appropriate if optimum use is to be made
of these frequencies, and the Commission has over the years made
a large number
of them
.

The few cases
of clear favoritism along social-class lines
are as likely as not to involve representatives
of the working
class on the school board who favor some such practice as higher wages for janitors rather than pay increases for teachers, and such issues
are not issues
of educational policy
.

They
are mostly upper-middle- and lower-middle-class people, with
a few in the upper
class.

However, there
are relatively few such political constituencies, and, as has been pointed out, there is seldom
a clear-cut distinction between the educational interests
of one social
class and those
of another
.

Like the other policy-making groups, these
are middle
class in their educational attitudes, and they attempt to act in the general public interest, as they see it
.

Thus, during any given year ( A ) if the revenues from the residential service
are $7,000,000, ( B ) if the operating expenses imputed to this
class of service come to $5,000,000, and ( C ) if the net investment in ( or value
of ) the plant and equipment deemed devoted to this service amounts to $30,000,000, the cost analyst will report that residential service, in the aggregate, has yielded
a return
of $2,000,000 or 6-2/3 per cent
.
are and 5-HT

SSRIs
are said to work by preventing the reuptake
of serotonin ( also known as 5-hydroxytryptamine, or
5-HT ) by the presynaptic neuron, thus maintaining higher levels
of 5-HT in the synapse
.

Serotonin-norepinephrine reuptake inhibitors ( SNRIs )
are a newer form
of antidepressants that work on both norepinephrine and
5-HT.

Of the four
5-HT receptor classes, 3
are GPCR and 1 is ligand gated cation channel
.

Both classes
of these drugs
are agonists at the
5-HT < sub > 2
</ sub > receptors ; this is thought to be the central component
of their hallucinogenic properties
.

Because
of the possible role
of serotonin in sleep patterns,
a new generation
of 5-HT < sub > 2
</ sub > antagonists
are in current development as hypnotics
.

Many monoamine neurotransmitters ; e
. g., norepinephrine ( noradrenalin ), dopamine, and serotonin (
5-HT )
are oxidizable
.

They
are also found in close association with serotonin (
5-HT ) and neurons containing norepinephrine that
are targeted by the currently used antidepressant drugs
.

**
5-HT < sub > 3
</ sub > receptor antagonists
are the primary drugs used to treat and prevent chemotherapy-induced nausea and vomiting
.

The leaves and stems
are very hairy with non-stinging hairs and also bear many stinging hairs ( trichomes ), whose tips come off when touched, transforming the hair into
a needle that will inject several chemicals: acetylcholine, histamine,
5-HT ( serotonin ), moroidin, leukotrienes, and possibly formic acid
.

In the case
of NET and SERT one Na
< sup >+</ sup
> and one Cl
< sup >-</ sup
> ion
are transported into the cell with one NE or
5-HT respectively
.

Indirect α
< sub > 1
</ sub >- adrenoceptor-mediated enhancement
of 5-HT cell firing and direct blockade
of inhibitory α
< sub > 2
</ sub >- heteroreceptors located on
5-HT terminals
are held responsible for the increase in extracellular
5-HT.

Serotonin binds
a number
of receptors, including the
5-HT < sub > 3
</ sub > receptors, which
are ligand-gated ion channels that allow the passage
of cations in order to depolarize the membrane potential
of the postsynaptic neuron that they reside on
.

For instance several excitatory ionotropic ligand-gated neurotransmitter receptors including glutamate receptors ( AMPA, NMDA, and kainate ), nicotinic acetylcholine ( nACh ), and serotonin (
5-HT < sub > 3
</ sub >) receptors
are nonselective cation channels that pass Na
< sup >+</ sup
> and K
< sup >+</ sup
> in nearly equal proportions, giving an equilibrium potential close to 0 mV
.

All
of these drugs exhibit inverse agonistic effects at the
5-HT < sub > 2A / 2C
</ sub > receptors, meaning serotonin abnormalites
are also involved in the complex constellation
of neurologic factors predisposing one to the self reinforcing language-based psychological deficits found in all forms
of psychosis
.

Some
of the enzymes
of the pinealocytes include
5-HT N-acetyl transferase and 5-hydroxyindole-O-methyltransferase which
are used to convert serotonin to melatonin
.

The serotonin receptors, also known as 5-hydroxytryptamine receptors or
5-HT receptors,
are a group
of G protein-coupled receptors ( GPCRs ) and ligand-gated ion channels ( LGICs ) found in the central and peripheral nervous systems
.

With the exception
of the
5-HT < sub > 3
</ sub > receptor,
a ligand-gated ion channel, all other serotonin receptors
are G protein-coupled receptors that activate an intracellular second messenger cascade to produce an excitatory or inhibitory response
.

While some
of the listed properties such as
5-HT < sub > 2A
</ sub > and D
< sub > 2
</ sub > blockade may be useful in certain indications such as in the treatment
of schizophrenia ( as with perospirone and tiospirone ), all
of them except
5-HT < sub > 1A </ sub > agonism
are generally undesirable in anxiolytics and only contribute to side effects
.

Its effects
are thought to come from its partial agonist activity at
5-HT < sub > 2A
</ sub > serotonin receptors in the prefrontal cortex
.
are and <

All 128 ASCII characters, including non-printable characters ( represented by their abbreviations ). The 95 ASCII graphic characters
are numbered from 20
< sub > hexadecimal | hex
</ sub > to 7E
< sub > hexadecimal | hex
</ sub > ( decimal 32 to 126 ).

When there
are only two means to compare, the t-test and the ANOVA F-test
are equivalent ; the relation between ANOVA and t is given by F = t
< sup
> 2
</ sup >.

The Arrhenius definition states that acids
are substances which increase the concentration
of hydronium ions ( H
< sub > 3
</ sub > O
< sup >+</ sup >) in solution
.

The reason why pHs
of acids
are less than 7 is that the concentration
of hydronium ions is greater than 10
< sup >− 7
</ sup
> moles per liter
.

In pure water the majority
of molecules exist as H
< sub > 2
</ sub > O, but
a small number
of molecules
are constantly dissociating and re-associating
.

The Brønsted-Lowry definition is the most widely used definition ; unless otherwise specified acid-base reactions
are assumed to involve the transfer
of a proton ( H
< sup >+</ sup >) from an acid to
a base
.

Reactions
of acids
are often generalized in the form HA H
< sup >+</ sup
> + A
< sup >−</ sup >, where HA represents the acid and A
< sup >−</ sup
> is the conjugate base
.

The numerical value
of K
< sub > a </ sub > is equal to the concentration
of the products divided by the concentration
of the reactants, where the reactant is the acid ( HA ) and the products
are the conjugate base and H
< sup >+</ sup >.

The basic principles
of general semantics, which include time-binding,
are described in the publication
< cite
> Science and Sanity
</ cite >, published in 1933
.

Isotopes that
are lighter than the stable
< sup
> 123
</ sup
> Sb tend to decay by β
< sup >+</ sup
> decay, and those that
are heavier tend to decay by β
< sup >-</ sup
> decay, with some exceptions
.

As with most lanthanides and actinides, actinium exists in the oxidation state + 3, and the Ac
< sup
> 3 +</ sup
> ions
are colorless in solutions
.

Only
a limited number
of actinium compounds
are known including AcF
< sub > 3
</ sub >, AcCl
< sub > 3
</ sub >, AcBr
< sub > 3
</ sub >, AcOF, AcOCl, AcOBr, Ac
< sub > 2
</ sub > S
< sub > 3
</ sub >, Ac
< sub > 2
</ sub > O
< sub > 3
</ sub > and AcPO
< sub > 4
</ sub >.
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