Azapirones are a class of 5-HT < sub > 1A </ sub > receptor agonists.

Azapirones are poorly but nonetheless appreciably absorbed and have a rapid onset of action, but have only very short half-lives ranging from 1 – 3 hours.

Azapirones have more tolerable adverse effects than many other available anxiolytics like the benzodiazepines.

Class 2, stations operating on clear channels are required to cease operation or operate under nighttime restrictions beginning either at local sunset ( for daytime class 2, stations ) or sunset at the location of the dominant class 1, station where located west of the class 2, station ( for limited-time class 2, stations ).

The same restrictions apply after local sunset in the case of class 3, stations operating on regional channels, which after that time are required to operate under nighttime restrictions in order to protect each other.

The class 1, stations on these clear channels are protected to their 0.1-mv./m. groundwave contours against daytime cochannel interference.

With respect to skywave service rendered at night, class 1, -- A stations are the only stations permitted to operate in the United States on clear channels specified for class 1, -- A operation, and so render skywave service free from cochannel interference whereever they may be received ; ;

class 1, -- B stations are protected at night to their 0.5-mv./m. 50-percent time skywave contours against cochannel interference.

Since the provision of skywave service requires adequate freedom from interference, only class 1, stations are capable of rendering skywave service.

With respect to other frequencies, these are designated as regional or local, and assigned for use by class 3, and class 4, stations, respectively, stations operating generally with lower power.

On the remainder of the clear channels, the dominant ( class 1 ) -- B stations are protected as described above, and the relatively small number of secondary ( class 2 ) ) stations permitted to operate on these channels at night are required to operate directionally and/or with reduced power so as to protect the class 1, stations.

Such additional daytime class 2, assignments are appropriate if optimum use is to be made of these frequencies, and the Commission has over the years made a large number of them.

The few cases of clear favoritism along social-class lines are as likely as not to involve representatives of the working class on the school board who favor some such practice as higher wages for janitors rather than pay increases for teachers, and such issues are not issues of educational policy.

They are mostly upper-middle- and lower-middle-class people, with a few in the upper class.

However, there are relatively few such political constituencies, and, as has been pointed out, there is seldom a clear-cut distinction between the educational interests of one social class and those of another.

Like the other policy-making groups, these are middle class in their educational attitudes, and they attempt to act in the general public interest, as they see it.

Thus, during any given year ( A ) if the revenues from the residential service are $7,000,000, ( B ) if the operating expenses imputed to this class of service come to $5,000,000, and ( C ) if the net investment in ( or value of ) the plant and equipment deemed devoted to this service amounts to $30,000,000, the cost analyst will report that residential service, in the aggregate, has yielded a return of $2,000,000 or 6-2/3 per cent.

For drugs are in themselves no royal road to creativity.

Huge industries are involved also in the production of biological products, drugs and cosmetics which are liable to this type of attack.

Antithyroid drugs are of two general types.

On the other hand, there are a few antithyroid drugs of this same general type, such as resorcinol, possessing no reducing activity and possibly acting through formation of a complex with molecular iodine.

The antithyroid drugs of the thiouracil type, however, are not antagonised by such means.

Water-soluble gums are used in foods and drugs and in the manufacture of pulp and paper as thickeners, stabilizers, or dispersing agents.

Other examples include various prescription drugs ( e. g. most antiepileptic drugs have cerebellar ataxia as a possible adverse effect ), Lithium level over 1. 5mEq / L, cannabis ingestion and various other recreational drugs ( e. g. ketamine, PCP or dextromethorphan, all of which are NMDA receptor antagonists that produce a dissociative state at high doses ).

Safety profiles of newer drugs are often not as well established as for those that have a long history of use.

However, as with other penicillin drugs, it is relatively non-toxic and adverse effects of a serious nature are encountered only rarely.

One possible target for drugs is the plastid, and in fact existing drugs such as tetracyclines which are effective against apicomplexans seem to operate against the plastid.

The analgesic choice is also determined by the type of pain: for neuropathic pain, traditional analgesics are less effective, and there is often benefit from classes of drugs that are not normally considered analgesics, such as tricyclic antidepressants and anticonvulsants.

These drugs ( such as rofecoxib, celecoxib and etoricoxib ) are equally effective analgesics when compared with NSAIDs, but cause less gastrointestinal hemorrhage in particular.

These drugs are used along with analgesics to modulate and / or modify the action of opioids when used against pain, especially of neuropathic origin.

They often have pharmacological effects and are used as medications, as recreational drugs, or in entheogenic rituals.

Tricyclic antidepressants are the second oldest class of antidepressant drugs.

They are used less commonly now due to the development of more selective and safer drugs.

Toxicity occurs at about ten times normal dosages ; these drugs are often lethal in overdoses, as they may cause a fatal arrhythmia.

As there are potentially fatal interactions between this class of medication and certain foods ( particularly those containing tyramine ), as well as certain drugs, classic MAOIs are rarely prescribed any more.

Amphetamine derivatives are a class of potent drugs that act by increasing levels of dopamine, norepinephrine, and serotonin in the brain, inducing euphoria.

The men who speculate on these institutions have, for the most part, come to at least one common conclusion: that many of the great enterprises and associations around which our democracy is formed are in themselves autocratic in nature, and possessed of power which can be used to frustrate the citizen who is trying to assert his individuality in the modern world ''.

Then, with staring eyes and lips drawn thin, Miriam said to the young woman, `` You are ugly -- uglier than you used to be, and you were always very ugly.

She used to tell me, `` When I stand there and look at the flag blowing this way and that way, I have the wonderful, safe feeling that Americans are protected no matter which way the wind blows ''.

The decision maker who acts for the community as a whole must decide whether the objectives pursued and the methods used are appropriate to public policy regarding cultural groups.

his broad but little used investigative powers are confirmed.

When different colors are used, she is just as likely to color trees purple, hair green, etc..

One cannot help wondering whether Molotov and the rest of the `` anti-party group '' are not being used as China's whipping-boys by Khrushchev and his faithful followers.

Proceeds realized from these pageants are used by the Jaycees to help support their various youth, health, welfare and community betterment activities throughout the state.

Since conventional methods are insensitive at the low frequencies of these molecular transitions, the paramagnetic resonance method is being used instead.

The funds recouped by reductions in item 12 above are used: first, to increase the unadjusted allotments to the specified minimum in those States where the unadjusted allotment is less than the minimum allotment ( item 13 above ) ; ;

Solid concrete blocks, relatively heavy and dense, are used for this shelter.

If they are used, the walls and roof should be 10 inches thick to give the same protection as the 8-inch solid concrete blocks.

It is thick, much like an egg plant's skin, so that poison sprays, if they are used, present no hazard to the consumer.

Such locks are nearly always used where the switch points `` face '' oncoming traffic.

Derails -- mechanical track devices that actually guide the wheels off the rails if a train passes a `` stop '' signal -- are used in many instances.

However, some formulas are used more than others.

The compression ratio arrived at with the formula will be the same regardless of whether cubic inches or cubic centimeters are used.

The only way to determine the final combustion chamber volume when such pistons are used is by measuring it with liquid while the cylinder head is bolted to the cylinder block and the piston is in top dead center position.

Photos of Conference Rooms and the General Assembly Hall can be made when these rooms are not being used for meetings.

Besides flathead bronze screws, silicon bronze Stronghold nails ( made by Independent Nail & Packing Co., Bridgewater, Mass. ) are used extensively in assembly and Weldwood resorcinol glue is used in all the joints.

After the frames and transom are set up on the jig and temporarily braced, a piece of three-inch-wide mahogany ( only widths will be given since the 13/16-inch thickness is used throughout ) is butted between frames one and two below the line of the keelson.

One-inch, No. 10 screws are used in both cases.

Glue and 1-1/2-inch, No. 10 screws are used.

Four pieces are used.