A phosphodiesterase inhibitor is a drug that blocks one or more of the five subtypes of the enzyme phosphodiesterase ( PDE ), therefore preventing the inactivation of the intracellular second messengers cyclic adenosine monophosphate ( cAMP ) and cyclic guanosine monophosphate ( cGMP ) by the respective PDE subtype ( s ).

In 1866, the motto " In God We Trust " was added to the Liberty Coronet double eagle creating a second subtype.

The second approach is to use the statement, which allows the dynamic subtype of a variable to be checked directly.

Since bowed instruments require a bow, the second category includes a subtype known as a bow maker or archetier.

The MIME type for this is multipart / signed with the second part having a MIME subtype of application /( x -) pkcs7-signature.

The first subtype of cells are responsible for processing red – green differences, and the second process blue – yellow differences.

The second subtype, posterolateral neck dissection, refers to the removal of the suboccipital lymph nodes, retroauricular lymph nodes, levels II-IV, and level V. This procedure is used most often to remove nodal disease from cutaneous melanoma of the posterior scalp and neck.

Traditional pharmacology posits that a ligand can be either classified as an agonist ( full or partial ), antagonist or more recently an inverse agonist through a specific receptor subtype, and that this characteristic will be consistent with all effector ( second messenger ) systems coupled to that receptor.

There had been a good second or two during which my muffler had been blowing out, and now I was certain I'd seen her somewhere before.

Their skin was covered with a thin coating of sweat and dirt which had almost the consistency of a second skin.

As for progress, the `` backward South '' can boast of Baton Rouge, which increased its population between 1940 and 1950 by two hundred and sixty-two percent, to 126,000, the second largest growth of the period for all cities over 25,000.

Nothing testifies more clearly to that cleavage than the peculiar editorial page appearing in a July issue of Life Magazine, the issue which also carried the second announcement of the candidacy.

The second involves something deeper, but its characteristic form focuses on a shift in policy for the community, not in the truth on which the community rests.

There is a second feature of the influences of literature, good literature, on emotional life which may have some special value for our time.

Upon second thought we were forced to realize that we have very few reliable historical benchmarks against which we might compare the present situation, and that conclusions that present-day students are `` more '' or `` less '' religious could not be defended on the basis of our data.

And the second requirement for convincing people without their knowledge is artistic talent to prepare the words and pictures which persuade by using the principles which the scientists have discovered.

The House was his habitat and there he flourished, first as a young representative, then as a forceful committee chairman, and finally in the post for which he seemed intended from birth, Speaker of the House, and second most powerful man in Washington.

When he came to Baltimore, he was leaving a team which was supposed to win the National League pennant, and he was joining what seemed to be a second division American League club.

In the second and third chapters of Revelation the new version retains, however, the old phrase `` angel of the church '' which Biblical scholars have previously interpreted as meaning bishop.

The 15th Street deposit is not to be confused with the nearby famous Mayflower Hotel cypress swamp on 17th Street reported in The Washington Post, August 2, 1955, which was probably formed during the second interglacial period and is therefore much younger.

The second great dilemma has been the morality of nuclear testing, a dilemma which has suddenly become acute because of the present series of Soviet tests.

The video signal is amplified and then switched, in synchronism with the three ultraviolet light sources which are sequenced by the rotating mirror so that during one-twentieth of a second only one wavelength, corresponding to red, green, or blue, is seen.

Clearly, any line, l, of any bundle having one of these points of tangency, T, as vertex will be transformed into the entire pencil having the image of the second intersection of L and Q as vertex and lying in the plane determined by the image point and the generator of Af which is tangent to **zg at T.

the second requires that there be a line through P which meets **zg in Af points.

In the second, the fixed elements are the lines which join the vertex, P, to the two intersections of **zg and the plane of the pencil which do not lie on the multiple secant.

Continuing with the case in which **zg is a Af curve on a quadric Q, we first observe that the second regulus of Q consists precisely of the lines which join the two free intersections of **zg and the planes through any one of the multiple secants.

These differences in turn result from the fact that my Yokuts vocabularies were built up of terms selected mainly to insure unambiguity of English meaning between illiterate informants and myself, within a compact and uniform territorial area, but that Hoijer's vocabulary is based on Swadesh's second glottochronological list which aims at eliminating all items which might be culturally or geographically determined.

The second productive period, the decade from 1910 to 1920, can be related to three events: the completion of The Dynasts in 1909, which left Hardy free of pressure for the first time in forty years ; ;

At the last second I dropped my sights from the bare chest and bright red circle to the chest of his pony.

Suddenly and not a second too soon I thought of the coins in my pocket.

I saw Johnson's bottle snatched from his hand, saw it go in a swirl of foam just behind the second car.

In spots such as the elbows and knees the second skin is worn off and I realized the aborigines were much darker than they appeared ; ;

I want, therefore, to discuss a second and quite different fruit of science, the connection between scientific understanding and fear.

During the next years he gave me the second of the five contracts I would sign with the Hearst Service.

Even apart from the fact that now at the age of 31 my personal life is being totally disrupted for the second time for no very compelling reason -- I cannot help looking around at the black leather jacket brigades standing idly on the street corners and in the taverns of every American city and asking myself if our society has gone mad.

I like to shear half my plants at a time, leaving one half of them to blossom while the second half is getting started on its new round of blooming.

Going through the Imperial Gate in the wall, I entered the grounds of Topkapi Palace, home of the Sultans and nerve center of the vast Ottoman Empire, and walked along a road toward another gate in the distance, past the Church of St. Irene, completed by Constantine in 330 A.D. on my left, and then, just outside the second gate, I saw a spring with a tap in the wall on my right -- the Executioner's Spring, where he washed his hands and his sword after beheading his victims.

Somehow managing to get out a cool, poised, `` Won't you hold on a second, please '', I covered up the mouthpiece, and with more warmth and less poise, gave a quick lecture on crime and punishment, mostly the latter, including Devil's Island and the remoter reaches of Siberia.

I thought for a second.

In the second sentence if drinking water is a gerundial clause and without drinking water is roughly equivalent in meaning to unless I drink water, there will be stronger stress on water than on drinking ; ;

In the Steiners have busy lives without visiting relatives only context can indicate whether visiting relatives is equivalent in meaning to paying visits to relatives or to relatives who are visiting them, and in I looked up the number and I looked up the chimney only the meanings of number and chimney make it clear that up is syntactically a second complement in the first sentence and a preposition followed by its object in the second.

If, as I suspect, the problem is largely of the second sort, then development of a theory better able to handle tone will result automatically in better theory for all phonologic subsystems.

On the positivist theory, everything I sought to express by calling it evil in the first case is still present in the second.

He hesitated a second, looking at the bottle, before he said `` Sure-sure '', and I reassured him.

The specific instance I have in mind is the Afro-Asian version which has gained prominence only in this second half of the twentieth century.

I grabbed her arm and she turned on me and for a scared second I thought that maybe Wally was right, and she was crazy.