By 2008, sales in the US reached $ 14. 6 billion, the biggest selling drugs in the US by therapeutic class.

By the end of his sole rule ( AD 14 ), Augustus had expanded the empire to the line of the Danube river, which was to remain its central / eastern European border for its entire history ( except for the occupation of Dacia 105-275 ).

By 14 he had already written a short adventure novel called The Black Diamonds which was lost for years until published in 2002.

By the end of the season, the rookie quarterback had rewritten the record book in Charlotte and many more in the NFL ( including most passing yards by a rookie with 4, 051, previously held by Peyton Manning with 3, 739 ; and most rushing touchdowns by a QB with 14 ).

By 1 July 1933 there were 1, 463 working camps with 250, 000 junior enrollees ( 18 – 25 years of age ), 28, 000 veterans, 14, 000 American Indians, and 25, 000 Locally Enrolled ( or Experienced ) Men ( LEM ).

By 1534 the Spanish crown had determined to split the region in two parallel lines, forming the governorship of " Nueva Castilla " ( from the 1 ° to the 14 ° latitude, close to Pisco ), and that of " Nueva Toledo " ( from the 14 ° to the 25 ° latitude, in Taltal, Chile ), assigning the first to Francisco Pizarro and the second to Diego de Almagro.

By 1990, floorball was recognized in 7 countries, and by the time of the first European Floorball Championships in 1994, that number had risen to 14.

By comparison, recent figures ( as of 14 November 2008 ) estimate Zimbabwe's annual inflation rate at 89. 7 sextillion ( 10 < sup > 21 </ sup >) percent., which corresponds to a monthly rate of 5473 %, and a doubling time of about five days.

By forging Mathieu as an absolute rationalist, analyzing every situation, and functioning entirely on reason, he removed any strands of authentic content from his character and as a result, Mathieu could " recognize no allegiance except to self " ( Sartre 1942: 13 ), though he realized that without " responsibility for my own existence, it would seem utterly absurd to go on existing " ( Sartre 1942: 14 ).

By 1952 a multiracial pattern of quotas allowed for 14 European, 1 Arab, and 6 Asian elected members, together with an additional 6 African and 1 Arab member chosen by the governor.

By the time Lewis and Clark arrived at the mouth of the Columbia, at least 14 maritime fur traders had already visited the river's mouth and estuary.

By the end of the Renaissance the number of courses had grown to ten, and during the Baroque era the number continued to grow until it reached 14 ( and occasionally as many as 19 ).

By 1949 Schaeffer's compositional work was known publicly as musique concrète ( Palombini 1993, 14 ).

By September, Porsche owned a 35. 14 % plurality stake in Volkswagen AG, effectively giving it control over the company.

By one single battle, the Battle of Agnadello on 14 May 1509, the dominion of Venice in Italy was practically lost.

By 1907, over 14, 000 clerks were providing service over of railroad.

By halftime, New England owned a surprising 14 – 3 lead.

Total dead 2, 050, 89-Other estimates of German casualties are as follows: By UK War Office in 1922: Killed 1, 808, 545 exclusive of 14, 000 African conscript deaths during the war By US War Dept in 1924: 1, 773, 700 killed and died.

* By this year, the Portuguese colony of Brazil has between 400 mills producing 57, 000 tons of sugar a year and 230 mills producing 14, 000 tons ( estimates vary ) The wealth the Portuguese acquire from selling sugar in Europe prompts the English and French to follow suit in this century.

By the end of September, 14 women including Bridget Bishop and 5 men had been hanged.

* April 14 – By the Treaty of Krakow, Poland and Hungary recognize the independence of Moldavia.

By the 12th century Italian flutes came in a variety of sizes, and fragments of 12th-century Norman bone whistles have been found in Ireland, and an intact 14 cm Tusculum clay whistle from the 14th century in Scotland.

By 14: 30, General Steinmetz, the commander of the First Army, unilaterally launched his VIII Corps across the Mance Ravine in which the Prussian infantry were soon pinned down by murderous rifle and mitrailleuse fire from the French positions.

By October the little colony about Fort Douglas ( present-day Winnipeg ) numbered 100.

By October 1993, Armenian forces succeeded in occupying almost all of former NKAO, Lachin and large areas in southwestern Azerbaijan.

By October he had taken a prospective hijacker Mushabib al-Hamlan from Afghanistan to Saudi Arabia where they both procured B-1 / B-2 tourist / business visas on October 28 – but Hamlan then decided not to proceed and is thought to have returned to his family.

By October 2007 bluetongue had become a serious threat in Scandinavia and Switzerland and the first outbreak in Denmark was reported.

By the time the offensive was ready in late October, Eighth Army had 231, 000 men on its ration strength.

By October, another vessel had been captured and added to the small fleet.

By October 1962, they may have had a few dozen, although some intelligence estimates were as high as 75.

By October 19, frequent U-2 spy flights showed four operational sites.

By the end of October, Allen was again off New York, where the British, having secured the city, moved the prisoners on-shore, and, as he was considered an officer, gave Allen limited parole.

By October 1558, Elizabeth was already making plans for her government.

By October 1935 his flat-mates had moved out and he was struggling to pay the rent on his own.

By the time You Bet Your Life debuted on TV on October 5, 1950, Groucho had grown a real mustache ( which he had already sported earlier in the films Copacabana and Love Happy ).

By October 20, ice is formed over all the rivers.

By May the release date had slipped from August to October.

By October, a first quarter 1990 release was envisaged.

By October 2003, Meteora sold nearly three million copies.

By October 1934, he had them surrounded, prompting them to engage in the " Long March ", a retreat from Jiangxi in the southeast to Shaanxi in the north west of China.

By 7 October 1966, the first floodlit game was held at Cardiff Arms Park, a game in which Cardiff RFC beat the Barbarians by 12 points to 8.

By August 21, however, it had increased in brightness by one magnitude, then by October had faded from view.

By 1939, with the exception of Stalin himself, none of the original Bolsheviks of the October Revolution of 1917 remained in the Party.

North Korean forces were soon defeated by September and driven northwards by United Nations forces led by the U. S. By October, the U. N. forces had retaken Seoul and captured Pyongyang, and it became Kim's turn to flee.

By the morning of 3 October 765 guns and 1, 000 rounds of ammunition were turned over.

By 1 October, 128 Type A barges had been converted to airscrew propulsion and, by the end of the month, this figure had risen to over 200.

By October 1917 there had been over four thousand peasant uprisings against landowners.