By 2008, sales in the US reached $ 14. 6 billion, the biggest selling drugs in the US by therapeutic class.

By expanding the conditions for which they were indicated, Astrazeneca's Seroquel and Eli Lilly's Zyprexa had become the biggest selling antipsychotics in 2008 with global sales of $ 5. 5 billion and $ 5. 4 billion respectively.

By 2008, numerous service areas and petrol stations had been constructed along all Croatian motorways.

By late 2008, the helmet had been dented almost beyond recognition.

By 2008, Dartmouth had graduated 238 classes of students and has over 60, 000 living alumni in a variety of fields.

By April 2008 two songs off this album were posted online.

By July 2008 various blogs referred to " an e-mail " from a colleague of the band's attorney that suggested the issue was " amicably resolved ".

By comparison, recent figures ( as of 14 November 2008 ) estimate Zimbabwe's annual inflation rate at 89. 7 sextillion ( 10 < sup > 21 </ sup >) percent., which corresponds to a monthly rate of 5473 %, and a doubling time of about five days.

By 2008, Hummer's viability in the economic downturn was being questioned, and it was placed under review by GM management.

By April 2008, whereupon he reached two years ' seniority, Harry was promoted to the rank of lieutenant.

By 2007 the " Bjäre julmust " was only sold at McDonald's restaurants and it had completely disappeared from Coca-Colas range of products by Christmas 2008, only to return for Christmas 2011.

* 2008: Gamma Player Compilation Vol 1: The Universe By Night

By comparison, in 2008 Koenigsegg with its staff of 45 produced 18 cars at an average price of US $ 1 million each ; Saab employed 3, 400 workers and made more than 93, 000 cars.

By the end of 2008, parties had a hard time agreeing on further budget cuts, ( mainly in the social sphere ) the planned reorganization of the government, and layoffs.

By 2008, worldwide sales of televisions with LCD screens exceeded annual sales of CRT units ; the CRT became obsolete for most purposes.

By 2008 there were at least six institutions monitoring lake water health: 1 ) In 2002 the Conservation Law Foundation appointed a " lakekeeper " who criticizes the state's pollution controls, 2 ) Friends of Missisquoi Bay was formed in 2003, 3 ) the Lake Champlain Committee, 4 ) Vermont Water Resources Board

By contrast, a previous study in 2008 had found only 38 percent of lemur species were at risk of extinction.

By 2008, most North American minivans had adopted the size and configuration of the long-wheelbase Chrysler vans, with Chrysler dropping their shorter models as well.

By 2008, more than 815, 000 vessels had passed through the canal, many of them much larger than the original planners could have envisioned ; the largest ships that can transit the canal today are called Panamax.

By 2008 there were several hundred casinos world wide offering roulette games.

By 2008, approximately 80 % to 90 % of commercially made cheeses in the US and Britain were made using FPC.

By 2008, these state-owned corporations had become increasingly dynamic and generated large increases in revenue for the state, resulting in a state-sector led recovery during the 2009 financial crises while accounting for most of China's economic growth.

By language, according to 2008 data, 21 % of the population always speak in Galician, 15 % always speak in Spanish and the rest use both interchangeably.

By 2008, the economy was 16. 7 times the size it was in 1978, and 12. 1 times its previous per capita levels.

By the opening of the 2008 General Conference, total UMC membership was estimated at 11. 4 million, with about 7. 9 million in the U. S. and 3. 5 million overseas.

By the month of August 1793, the allied Coalition Army under command of the Austrian Prince of Coburg had taken Condé, Valenciennes, and Le Cateau and were poised on the Franco Belgian border.

By his first wife, Diane de Budos de Portes, a relative of Condé, whom he married in 1644 and who died in 1670, he had three daughters.

By 1789, there were 43, including five held by princes of the blood ( Orléans, Condé, Bourbon, Enghien, and Conti ), ( Penthièvre ) ( who was the son of a legitimized prince, the Count of Toulouse, also a pair de France ), and 37 other lay peers, ranking from the Duchy of Uzès, created in 1572, to the Duchy of Aubigny, created in 1787.

By inheritance it passed to Henry III Jules de Bourbon, prince de Condé, whose widow Anne, princesse palatine de Bavière, made it the habitual residence of her widowhood, making adjustments to suit her status that included the grand staircase and salon by Germain Boffrand ( 1709 – 1713 ) and adding another hôtel for her household, with her kitchens and stables, on the other side of rue de Vaugirard ; an underground passage linked the two residences.

By moving through the possessions of Münster and Cologne and a few other French allies, the army of Louis XIV, led by Louis II de Bourbon, Prince de Condé and Turenne was able to pass through the Spanish Netherlands and bypass the Dutch defense in the south and invade the Dutch from the east in June.

By Thomas Nast in Harper's Weekly, 1877 Feb. 17, p. 132.

By failing to do as he was told instantly -- to take out a permit or return the gun to his car -- he had played into Lord's hands.

By now Curt was seeing clearly again.

By her eighteenth birthday her bent for writing was so evident that Papa and Mamma gave her a Life Of Dickens as a spur to her aspiration.

By now she was sure she was going to have a baby, deciding it would be born in India or Burma that November.

By this time she had learned that it was futile to argue with her young husband, yet the uncomfortable fact remained: the American Congregationalists were sending them as missionaries to the Far East and paying their salaries.

By now he was undergoing a fresh torrent of abuse from Tory papers and pamphlets, and action was being taken to effect his punishment by expulsion from Parliament.

By this time word had got around that an American doctor was on the premises.

By our policy the West was -- is -- split.

By the time he was under the covers he had forgotten about seeing Kate.

By the time he was prosperous enough -- his goals were high -- he was bald and afraid of women.

By late afternoon the train inched into the marshaling yards in the railhead at Lublin, which was filled with lines of cars poised to pour the tools of war to the Russian front.

By odd coincidence, on the evening of her return Shelley chose to read Parisina, which was the latest of the titled poet's successes.

By the time the film was released we were three million dollars over-spent, war was imminent and the public apparently had forgotten all about Mother Cabrini.

By this method it was determined that the normal pressure exerted by a sample of polybutene ( molecular weight reported to be 770 ) was over half an atmosphere.

By comparing reaction cells sealed from the same manifold temperature dependency corresponding to activation energies ranging from 11 to 18 Af was observed while dependence on the first power of the light intensity seemed to be indicated in most cases.

By Nov. 8, 1958, weakness, specifically involving the pelvic and thigh musculature, was pronounced, and a common complaint was `` difficulty in stepping up on to curbs ''.

Serum potassium at this time was 3.8 mEq. per liter, and the hemoglobin was 13.9 gm. By Dec. 1, 1958, the weakness in the pelvic and quadriceps muscle groups was appreciably worse, and it became difficult for the patient to rise unaided from a sitting or reclining position.