By expanding the conditions for which they were indicated, Astrazeneca's Seroquel and Eli Lilly's Zyprexa had become the biggest selling antipsychotics in 2008 with global sales of $ 5. 5 billion and $ 5. 4 billion respectively.

By 2008, numerous service areas and petrol stations had been constructed along all Croatian motorways.

By late 2008, the helmet had been dented almost beyond recognition.

By 2008, Dartmouth had graduated 238 classes of students and has over 60, 000 living alumni in a variety of fields.

By April 2008 two songs off this album were posted online.

By July 2008 various blogs referred to " an e-mail " from a colleague of the band's attorney that suggested the issue was " amicably resolved ".

By comparison, recent figures ( as of 14 November 2008 ) estimate Zimbabwe's annual inflation rate at 89. 7 sextillion ( 10 < sup > 21 </ sup >) percent., which corresponds to a monthly rate of 5473 %, and a doubling time of about five days.

By 2008, Hummer's viability in the economic downturn was being questioned, and it was placed under review by GM management.

By April 2008, whereupon he reached two years ' seniority, Harry was promoted to the rank of lieutenant.

By 2007 the " Bjäre julmust " was only sold at McDonald's restaurants and it had completely disappeared from Coca-Colas range of products by Christmas 2008, only to return for Christmas 2011.

* 2008: Gamma Player Compilation Vol 1: The Universe By Night

By comparison, in 2008 Koenigsegg with its staff of 45 produced 18 cars at an average price of US $ 1 million each ; Saab employed 3, 400 workers and made more than 93, 000 cars.

By the end of 2008, parties had a hard time agreeing on further budget cuts, ( mainly in the social sphere ) the planned reorganization of the government, and layoffs.

By 2008, worldwide sales of televisions with LCD screens exceeded annual sales of CRT units ; the CRT became obsolete for most purposes.

By 2008 there were at least six institutions monitoring lake water health: 1 ) In 2002 the Conservation Law Foundation appointed a " lakekeeper " who criticizes the state's pollution controls, 2 ) Friends of Missisquoi Bay was formed in 2003, 3 ) the Lake Champlain Committee, 4 ) Vermont Water Resources Board

By contrast, a previous study in 2008 had found only 38 percent of lemur species were at risk of extinction.

By 2008, most North American minivans had adopted the size and configuration of the long-wheelbase Chrysler vans, with Chrysler dropping their shorter models as well.

By 2008, more than 815, 000 vessels had passed through the canal, many of them much larger than the original planners could have envisioned ; the largest ships that can transit the canal today are called Panamax.

By 2008 there were several hundred casinos world wide offering roulette games.

By 2008, approximately 80 % to 90 % of commercially made cheeses in the US and Britain were made using FPC.

By 2008, these state-owned corporations had become increasingly dynamic and generated large increases in revenue for the state, resulting in a state-sector led recovery during the 2009 financial crises while accounting for most of China's economic growth.

By language, according to 2008 data, 21 % of the population always speak in Galician, 15 % always speak in Spanish and the rest use both interchangeably.

By 2008, the economy was 16. 7 times the size it was in 1978, and 12. 1 times its previous per capita levels.

By the opening of the 2008 General Conference, total UMC membership was estimated at 11. 4 million, with about 7. 9 million in the U. S. and 3. 5 million overseas.

By the summer of 1823, Alcott returned to Connecticut in debt to his father, who bailed him out after his last two unsuccessful sales trips.

By the time of his death sales of the company had reached C $ 20 million, which is the equivalent of C $ 160 million in 2004 dollars.

By changing Bovril to a non-meat base, Unilever hoped to increase sales there, where people enjoy Bovril stirred into porridge.

By evaluating “ buy signals ,” marketers can see which prospects are most likely to transact and also identify those who are bogged down in a sales process and need assistance.

By the beginning of 1984, quarterly sales of the ColecoVision had dramatically decreased.

By 1990, Compaq Europe was a $ 2 billion business, and foreign sales contributed 54 percent of Compaq's revenues.

By late 2006, HP had retook the # 1 sales position of PCs from Dell, which struggled with missed estimates and poor quality, and has held that rank ever since.

By the mid-1980s, her record sales were still relatively strong, with " Save the Last Dance for Me ", " Downtown ", " Tennessee Homesick Blues " ( all 1984 ); " Real Love " ( another duet with Kenny Rogers ), " Don't Call It Love " ( both 1985 ); and " Think About Love " ( 1986 ) all reaching the country-singles Top 10.

By 1968 Thomas had increased sales in the four fried chicken restaurants so much that he sold his share in them back to Sanders for more than $ 1. 5 million.

By the 1530s, the writings of Erasmus accounted for 10 to 20 percent of all book sales.

By the time the film " The Empire Strikes Back " was released in 1980 Star Wars fanzines had surpassed Star Trek zines in sales.

By the time of Daniel Deronda, Eliot's sales were falling off, and she faded from public view to some degree.

By 1982, sales were soaring.

By the end of 2007, each episode of the original TV series averaged a sales figure of 80, 928 copies, including all of the different formats it was published in ( VHS, LD, DVD, etc .).

By allowing possession and retail sales of cannabis, but not cultivation or wholesale, the government creates numerous problems of crime and public safety, he alleges, and therefore he would like to switch to either legalising and regulating production, or to the full repression that his party ( CDA ) officially advocates.

By 1994, sales of CD-i systems had begun to slow, and in 1998 the product line was dropped.

By 1907, REO had gross sales of $ 4. 5 million and the company was one of the four wealthiest automobile manufacturers in the U. S. After 1908 however, despite the introduction of improved cars designed by Olds, REO's share of the automobile market decreased due in part to competition from emerging companies like Ford and General Motors.

By the 2000s, the majority of sales were in the United States, where the beer has proven extremely popular, although it still sells 100 million bottles annually in the UK.

By this time, his sales had decreased.

By 1916, Chevrolet was profitable enough with successful sales of the cheaper Series 490 to allow Durant to repurchase a controlling interest in General Motors.

By this point, Queen's vast amount of record sales made them the second best selling artist in the UK of all time, behind The Beatles.