By 2008, sales in the US reached $ 14. 6 billion, the biggest selling drugs in the US by therapeutic class.

By expanding the conditions for which they were indicated, Astrazeneca's Seroquel and Eli Lilly's Zyprexa had become the biggest selling antipsychotics in 2008 with global sales of $ 5. 5 billion and $ 5. 4 billion respectively.

By 2008, numerous service areas and petrol stations had been constructed along all Croatian motorways.

By late 2008, the helmet had been dented almost beyond recognition.

By 2008, Dartmouth had graduated 238 classes of students and has over 60, 000 living alumni in a variety of fields.

By April 2008 two songs off this album were posted online.

By July 2008 various blogs referred to " an e-mail " from a colleague of the band's attorney that suggested the issue was " amicably resolved ".

By comparison, recent figures ( as of 14 November 2008 ) estimate Zimbabwe's annual inflation rate at 89. 7 sextillion ( 10 < sup > 21 </ sup >) percent., which corresponds to a monthly rate of 5473 %, and a doubling time of about five days.

By 2008, Hummer's viability in the economic downturn was being questioned, and it was placed under review by GM management.

By April 2008, whereupon he reached two years ' seniority, Harry was promoted to the rank of lieutenant.

By 2007 the " Bjäre julmust " was only sold at McDonald's restaurants and it had completely disappeared from Coca-Colas range of products by Christmas 2008, only to return for Christmas 2011.

* 2008: Gamma Player Compilation Vol 1: The Universe By Night

By comparison, in 2008 Koenigsegg with its staff of 45 produced 18 cars at an average price of US $ 1 million each ; Saab employed 3, 400 workers and made more than 93, 000 cars.

By the end of 2008, parties had a hard time agreeing on further budget cuts, ( mainly in the social sphere ) the planned reorganization of the government, and layoffs.

By 2008, worldwide sales of televisions with LCD screens exceeded annual sales of CRT units ; the CRT became obsolete for most purposes.

By 2008 there were at least six institutions monitoring lake water health: 1 ) In 2002 the Conservation Law Foundation appointed a " lakekeeper " who criticizes the state's pollution controls, 2 ) Friends of Missisquoi Bay was formed in 2003, 3 ) the Lake Champlain Committee, 4 ) Vermont Water Resources Board

By contrast, a previous study in 2008 had found only 38 percent of lemur species were at risk of extinction.

By 2008, most North American minivans had adopted the size and configuration of the long-wheelbase Chrysler vans, with Chrysler dropping their shorter models as well.

By 2008, more than 815, 000 vessels had passed through the canal, many of them much larger than the original planners could have envisioned ; the largest ships that can transit the canal today are called Panamax.

By 2008 there were several hundred casinos world wide offering roulette games.

By 2008, approximately 80 % to 90 % of commercially made cheeses in the US and Britain were made using FPC.

By 2008, these state-owned corporations had become increasingly dynamic and generated large increases in revenue for the state, resulting in a state-sector led recovery during the 2009 financial crises while accounting for most of China's economic growth.

By language, according to 2008 data, 21 % of the population always speak in Galician, 15 % always speak in Spanish and the rest use both interchangeably.

By 2008, the economy was 16. 7 times the size it was in 1978, and 12. 1 times its previous per capita levels.

By the opening of the 2008 General Conference, total UMC membership was estimated at 11. 4 million, with about 7. 9 million in the U. S. and 3. 5 million overseas.

By 2006, although the price points of CRTs were generally much lower than LCD and plasma flat panels, large screen CRTs ( 30-inches or more ) were as expensive as a similar-sized LCD.

By the mid-1990s, Compaq's price war had enabled it to overtake IBM and Apple, while other IBM PC Compatible manufacturers such as Packard Bell and AST were driven from the market.

By the time of cancellation, however, second-generation RISC chips ( such as the newer SPARC architecture ), were offering much better price / performance ratios than the VAX lineup.

By restricting the sale of land leases, the Hong Kong government keeps the price of land at what some would say are artificially high prices and this allows the government to support public spending with a low tax rate.

By 2000, the consolidation of grocery store chains, the spread of retailers like Wal-Mart, and growth of private-label brands caused competition for shelf space, and put price pressure on the company's products.

By capturing the islands Magnus imposed a more direct royal control, although at a price.

By the time Infocom removed the copy-protection and reduced the price to less than $ 100, it was too late, and the market had moved on to other database solutions.

By the turn of the 21st century, the turntable had become a niche product, as the price of CD players, which reproduce music free from pops and scratches, fell far lower than high fidelity tape players or turntables.

By bidding up the price of housing, many white neighborhoods effectively shut out blacks, because blacks are unwilling, or unable, to pay the premium to buy entry into these expensive neighborhoods.

By contrast, responses to changes in the price of the good are represented as movements along unchanged supply and demand curves.

By its very nature, conceptualizing a supply curve requires that the firm be a perfect competitor — that is, that the firm has no influence over the market price.

By its very nature, conceptualizing a demand curve requires that the purchaser be a perfect competitor — that is, that the purchaser has no influence over the market price.

* By what is the price of a commodity determined ?, a brief statement of Karl Marx's rival account

By 1931 the studio began to feel the effects of the Depression as the public became unable to afford the price of a movie ticket.

By the early 2000s, there was little price difference between a hub and a low-end switch.

By 110 BCE Emperor Wu also interfered with the profitable trade in grain when he eliminated speculation by selling government-stored grain at a lower price than demanded by merchants.

Urban growth boundaries have come under an increasing amount of scrutiny in the past 10 years as housing prices have substantially risen, especially on the West Coast of the U. S. By limiting the supply of developable land, critics argue, UGBs increase the price of existing developable and already-developed land.

By the late 1980s buyers began to regard PCs as commodities, and doubted that the security blanket of the IBM brand warranted the greater price.

By the latter part of 1720, however, the company had begun to collapse as the price of its shares plunged.

By setting this record, Steinway broke its own 1997 price record of $ 390, 000.

By 1938, only four years after the beginning of the Federal Housing Association, a house could be purchased for a down payment of only ten percent of the purchase price.

By that time, WorldCom ’ s stock price was declining and Ebbers came under increasing pressure from banks to cover margin calls on his WorldCom stock that was used to finance his other businesses ( timber and yachting, among others ).

By the summer of 1929, it was clear that the economy was contracting and the stock market went through a series of unsettling price declines.

By selling his crop in advance at a fixed price to a speculator, the farmer can hedge the price risk and is now willing to plant the corn.