By 2008, sales in the US reached $ 14. 6 billion, the biggest selling drugs in the US by therapeutic class.

By expanding the conditions for which they were indicated, Astrazeneca's Seroquel and Eli Lilly's Zyprexa had become the biggest selling antipsychotics in 2008 with global sales of $ 5. 5 billion and $ 5. 4 billion respectively.

By 2008, numerous service areas and petrol stations had been constructed along all Croatian motorways.

By late 2008, the helmet had been dented almost beyond recognition.

By 2008, Dartmouth had graduated 238 classes of students and has over 60, 000 living alumni in a variety of fields.

By April 2008 two songs off this album were posted online.

By July 2008 various blogs referred to " an e-mail " from a colleague of the band's attorney that suggested the issue was " amicably resolved ".

By comparison, recent figures ( as of 14 November 2008 ) estimate Zimbabwe's annual inflation rate at 89. 7 sextillion ( 10 < sup > 21 </ sup >) percent., which corresponds to a monthly rate of 5473 %, and a doubling time of about five days.

By 2008, Hummer's viability in the economic downturn was being questioned, and it was placed under review by GM management.

By April 2008, whereupon he reached two years ' seniority, Harry was promoted to the rank of lieutenant.

By 2007 the " Bjäre julmust " was only sold at McDonald's restaurants and it had completely disappeared from Coca-Colas range of products by Christmas 2008, only to return for Christmas 2011.

* 2008: Gamma Player Compilation Vol 1: The Universe By Night

By comparison, in 2008 Koenigsegg with its staff of 45 produced 18 cars at an average price of US $ 1 million each ; Saab employed 3, 400 workers and made more than 93, 000 cars.

By the end of 2008, parties had a hard time agreeing on further budget cuts, ( mainly in the social sphere ) the planned reorganization of the government, and layoffs.

By 2008, worldwide sales of televisions with LCD screens exceeded annual sales of CRT units ; the CRT became obsolete for most purposes.

By 2008 there were at least six institutions monitoring lake water health: 1 ) In 2002 the Conservation Law Foundation appointed a " lakekeeper " who criticizes the state's pollution controls, 2 ) Friends of Missisquoi Bay was formed in 2003, 3 ) the Lake Champlain Committee, 4 ) Vermont Water Resources Board

By contrast, a previous study in 2008 had found only 38 percent of lemur species were at risk of extinction.

By 2008, most North American minivans had adopted the size and configuration of the long-wheelbase Chrysler vans, with Chrysler dropping their shorter models as well.

By 2008, more than 815, 000 vessels had passed through the canal, many of them much larger than the original planners could have envisioned ; the largest ships that can transit the canal today are called Panamax.

By 2008 there were several hundred casinos world wide offering roulette games.

By 2008, approximately 80 % to 90 % of commercially made cheeses in the US and Britain were made using FPC.

By 2008, these state-owned corporations had become increasingly dynamic and generated large increases in revenue for the state, resulting in a state-sector led recovery during the 2009 financial crises while accounting for most of China's economic growth.

By language, according to 2008 data, 21 % of the population always speak in Galician, 15 % always speak in Spanish and the rest use both interchangeably.

By 2008, the economy was 16. 7 times the size it was in 1978, and 12. 1 times its previous per capita levels.

By the opening of the 2008 General Conference, total UMC membership was estimated at 11. 4 million, with about 7. 9 million in the U. S. and 3. 5 million overseas.

By extending this help, we hope to make possible the enthusiastic enrollment of these nations under freedom's banner.

By a combination of music, lighting effects, and narration, famous events that have transpired in these locations are evoked and re-created for large audiences usually to considerable acclaim.

By 1965, several or all of these systems will have been fully tested and their reliability established.

By using the appropriate version any one of these factors can be determined for any combination of the other three.

By these measures, Congress, so the Court ( in effect ) now decides, gave not only needless but inadequate relief, since it now appears that the federal courts have inherent power to sterilize the Act of 1875 against all proceedings challenging local regulation ''.

By these steps the final AIA list was reduced from 8,000 to 3,500.

By virtue of the legal responsibilities of the Department of Employment in the farm placement program, we necessarily found ourselves in the middle between these two forces.

By preying on the sick, by playing callously on the hopes of the desperate, by causing the sufferer to delay proper medical care, these medical ghouls create pain and misery by their very activity.

By no means are these isolated cases.

By 1926, when the mighty Yanks were at their mightiest, only a few of these were left but they still shone brightest, even beside able and agile rookies like Tony Lazzeri ( who managed never to have one of his epileptic fits on the field ), Mark Koenig, Lou Gehrig, George Pipgras, and gray-thatched Earl Combs.

By reminding ourselves of these factors in the situation, we should, I am sure, come to a fresh realization, however painful it be, that the battle between Parker and his neighbors was fought in earnest.

By studying these images, they can detect solar system objects by their movements relative to the background stars, which remain fixed.

By the beginning of the 8th century, these kingdoms had either been conquered by Nicene neighbors ( Ostrogoths, Vandals, Burgundians ) or their rulers had accepted Nicene Christianity ( Visigoths, Lombards ).

By reducing detail in one direction more than another, these effects can be reduced.

Whenever any result is sought by its aid, the question will then arise — By what course of calculation can these results be arrived at by the machine in the shortest time?

By and large the power exercised by these officials was routine administration and quite limited.

By 500 BC, Ionia appears to have been ripe for rebellion against these Persian clients.

By 454, the Delian League could be fairly characterized as an Athenian Empire ; at the start of the Peloponnesian War, only Chios and Lesbos were left to contribute ships, and these states were by now far too weak to secede without support.

By late 1983 it was clear that IBM's Token Ring would not be ready in time for the launch of the Mac, and might miss the launch of these other products as well.

By this point Apple had a wide variety of communications products under development, and many of these were announced along with AppleTalk Phase II.

By the help of these discoveries, Angle civilization in the age preceding the invasion of Britannia can be fitted together.

By the 1930s, statisticians and models built on statistical reasoning had helped to resolve these differences and to produce the neo-Darwinian modern evolutionary synthesis.

By the time the federal environmental clearances were delivered in 1994, A $ 10 million contract, signed off as a cost overrun, was used to repair these leaks.

By making these data available to local public health officials in real time, most models of anthrax epidemics indicate that more than 80 % of an exposed population can receive antibiotic treatment before becoming symptomatic, and thus avoid the moderately high mortality of the disease.

By the early 2000s, these competitions were named Comic Idol ( in reference to Pop Idol.