By 2008, sales in the US reached $ 14. 6 billion, the biggest selling drugs in the US by therapeutic class.

By expanding the conditions for which they were indicated, Astrazeneca's Seroquel and Eli Lilly's Zyprexa had become the biggest selling antipsychotics in 2008 with global sales of $ 5. 5 billion and $ 5. 4 billion respectively.

By 1888, over 3, 000 British public houses, grocers and chemists were selling Bovril.

By the recent turn of the century, however, his paintings were selling for millions.

By the end of this conflict, Commodore had shipped somewhere around 22 million C64s — making the C64 the best selling computer of all time.

By 1959, the company had dealers across the U. S. and began selling the 310 ( known as Bluebird domestically ).

By age nine he was growing, grinding, bottling and selling his own brand of horseradish sauce, based on his mother's recipe.

By the mid-1970s filmmakers avoided the genre in favor of using music by popular rock or pop bands as background music, partly in hope of selling a soundtrack album to fans.

" By 1884 he was selling Moxie both in bottles and in bulk as a soda fountain syrup.

By 2009, 27 coffee shops selling cannabis in Rotterdam, all within 200 metres from schools, must close down.

By 1955, restaurants throughout the area were using the term " hoagie ", with many selling hoagies and subs or hoagies and pizza.

" By 2005 Škoda was selling over 30, 000 cars a year in the UK, a market share of over 1 %.

By simply selling their work for wages, " workers simultaneously lose connection with the object of labor and become objects themselves.

By the time the game was released for the Sega Saturn in Japan, the game and system were selling at almost a one-to-one ratio.

By occasionally selling off minute quantities of the metal, T ' Chaka funded his country's education.

* By this year, the Portuguese colony of Brazil has between 400 mills producing 57, 000 tons of sugar a year and 230 mills producing 14, 000 tons ( estimates vary ) The wealth the Portuguese acquire from selling sugar in Europe prompts the English and French to follow suit in this century.

By the late 1980s, complete Synclavier systems were selling for upwards of $ 200, 000, to famous musicians such as Sting, Michael Jackson and Stevie Wonder, and to major studios the world over.

By selling the product in the market he pays rent of land, wages to labour, interest on capital and what remains is his profit.

By this point, Queen's vast amount of record sales made them the second best selling artist in the UK of all time, behind The Beatles.

* By functions: production, selling, distribution, administration, R & D, development,

By 110 BCE Emperor Wu also interfered with the profitable trade in grain when he eliminated speculation by selling government-stored grain at a lower price than demanded by merchants.

By 1977, the company was selling a heat-resistant duct tape for heating ducts.

By 1865 he had moved into banking and specialized in selling municipal, state, and government bonds.

By 1942 Rockefeller had become increasingly impatient that his purchased property might never be added to the park, and wrote to the Secretary of the Interior Harold L. Ickes that he was considering selling the land to another party.

By mid-June, millions of Americans will take to the road on vacation trips up and down and back and forth across this vast and lovely land.

By 1850, Luanda was one of the greatest and most developed Portuguese cities in the vast Portuguese Empire outside Mainland Portugal, full of trading companies, exporting ( together with Benguela ) palm and peanut oil, wax, copal, timber, ivory, cotton, coffee, and cocoa, among many other products.

By the 1960s the school was building a vast publishing and research network reaching across France, Europe, and the rest of the world.

By the time of his death, Mahmud ruled a vast empire that stretched from Kurdistan to the entire Hindu Kush region as far east as the Punjab as well as territories far north of the Amu Darya.

By 1960, the vast majority of country-states were nominally democracies, although most of the world's populations lived in nations that experienced sham elections, and other forms of subterfuge ( particularly in Communist nations and the former colonies.

By that time, there was great concern that the national deficit had risen dangerously and President Ronald Reagan had declared that a vast amount of government spending was being misused through waste and fraud.

By the 3rd century, the Goths ruled a vast area north of the Black Sea from where they either through crossing the lower Danube or traveling by sea, raided the Balkan Peninsula and Anatolia as far as Cyprus.

By 1990 Japan's interaction with the vast majority of Asia-Pacific countries, especially its burgeoning economic exchanges, was multifaceted and increasingly important to the recipient countries.

By the 15th century, the Sengoku Jidai civil war erupted, and the vast need for swords together with the ferocity of the fighting caused the highly artistic techniques of the Kamakura period ( known as the " Golden Age of Swordmaking ") to be abandoned in favor of more utilitarian and disposable weapons.

By 1850, Luanda was one of the greatest and most developed Portuguese cities in the vast Portuguese Empire outside Mainland Portugal, full of trading companies, exporting ( together with Benguela ) palm and peanut oil, wax, copal, timber, ivory, cotton, coffee, and cocoa, among many other products.

By the middle of the century, the Persians had been driven from the Aegean and forced to cede control of a vast range of territories to Athens.

By the 11th and 12th century, the nomadic confederacy of the Cumans and ( Eastern ) Kipchaks ( who are considered to be either the eastern branch of the Cumans or a distinct but related tribe with whom the Cumans created a confederacy ) were the dominant force over the vast territories stretching from the present-day Kazakhstan, southern Russia, Ukraine, to southern Moldavia and western Wallachia.

By implication, it was part of the vast Hercynian Forest belt mentioned by several authors of the antiquity.

By 1970 the DGI had managed to train hundreds of Sandinista guerrilla leaders and had vast influence over the organization.

By dictionary entries, the term subcontinent signifies " having a certain geographical or political independence " from the rest of the continent, or " a vast and more or less self-contained subdivision of a continent.

By the 1840s, India was no longer capable of supplying the vast quantities of cotton fibers needed by mechanized British factories, while shipping bulky, low-price cotton from India to Britain was time-consuming and expensive.

By the sale of offices, the establishment of new " Monti " and by levying new taxes, he accumulated a vast surplus, which he stored up against certain specified emergencies, such as a crusade or the defence of the Holy See.

By the 1660s, the slave population numbered about 2, 500 ; the number of indigenous people was estimated at 50, 000, most of whom had retreated into the vast hinterland.

By that time, the vast majority of the practices were also available in Tibet, where they were preserved until recently.

By radio Rodricks describes a vast burning column ascending from the planet.

By this point the output of the Workshop was vast with high demand for complete scores for programmes as well as the themes and sound effects for which it had made its name.

By 1925, Stewart-Warner odometers and trip meters were standard equipment on the vast majority of automobiles and motorcycles manufactured in the United States.

By that time, however, you could still see vast sugarcane fields in the " Montellano " area of Cayey and the " Central " where the sugarcane was processed.