Despite extensive attempts to obtain highly pure reagents, serious difficulty was experienced in obtaining reproducible rates of reaction.

Despite serious terrain obstacles, almost three-quarters of all cross-border dry cargo is now transported by road, 105, 251 metric tons in 2005.

Despite its many ( serious ) limitations, including extremely low volume, it has considerable expressive power, the player being able to control attack, duration, volume, and even provide certain subtle effects of swelling of tone and a type of vibrato unique to the clavichord.

Despite the fact that Parsons only contributed two new songs to the album (" In My Hour of Darkness ", " Return of the Grievous Angel "), Parsons was highly enthused with his new sound and seemed to have finally adopted a serious, diligent mindset to his musical career, eschewing most drugs and alcohol during the sessions.

Despite its unpleasantness and expense, a diagnostic fast may be the only effective way to confirm or refute a number of serious forms of hypoglycemia, especially those involving excessive insulin.

Despite the arrival of serious competitors — namely, the Ford Falcon, Chrysler Valiant, and Japanese cars — in the 1960s, Holden's locally produced large six-and eight-cylinder cars remained Australia's top-selling vehicles.

Despite his reputation as a serious composer of large, complex musical structures, some of Brahms's most widely known and most commercially successful compositions during his life were small-scale works of popular intent aimed at the thriving contemporary market for domestic music-making ; indeed, during the 20th century, the influential American critic B. H. Haggin, rejecting more mainstream views, argued in his various guides to recorded music that Brahms was at his best in such works and much less successful in larger forms.

Despite a serious injury which ruled Shearer out for half the season, Dalglish achieved fourth position with the team in the first year of the new Premier League.

Despite these hindrances, his aim ( and that of his collaborator John Dryden ) was to establish serious opera in England, but these hopes ended with Purcell's early death at the age of 36.

Despite the economy's general expansion after 1983, however, inflation threatened its modest gains, as did serious fiscal and balance-of-payments deficits and the growing debt.

Despite the official government statement that allowed for freedom of the press, this was the first trial of whether or not Dubcek was serious about reforms.

Despite these serious negative effects the measure was deemed necessary as tax revenue from provinces occupied and threatened by rebels had ceased to reach the cash-strapped central government.

Despite this apparent success the underlying problems remained unresolved and had already resulted in the death or serious injury of 30, 000 civilians.

Despite suffering from a serious flare-up of his chronic colitis, Lawrence decided to go, but he became ill while in Geneva, and was rushed to the hospital at Stanford University.

Despite the disdain of sousaphones held by most serious tuba players, a quality modern sousaphone is often a better choice for the high school or semi-pro player due to more stable intonation and less breath effort needed to generate tone.

Despite the continuation of single party politics ( known in this case as the Era of Good Feelings ), serious issues emerged during the election in 1820.

Despite serious cash flow problems, they moved UPI's headquarters from New York City to Washington DC, incurring additional major costs due to construction cost overruns.

Despite his occasional ( if serious ) political setbacks — usually at the hands of his great Machiavellian rival, Louis XI of France — Edward was a popular and very able king.

" Despite a serious preservation effort, The Museum of Arts & Design radically altered the building, which reopened in 2008.

Despite all these notable successes in diagnostics and detection techniques ectopic pregnancy remains a source of serious maternal morbidity and mortality worldwide, especially in countries with poor prenatal care.

Despite an arrest record dating back to the 1920s, Bonanno was never convicted of a serious crime.

Despite undoubted successes, Boleslaus III Wrymouth committed serious political errors, even against Zbigniew of Poland, his half-brother.

Despite a serious mutiny in 588, the army managed to continue the war and even secure a major victory before Martyropolis.

Despite serious initial problems with the Austrian censors who had control over northern Italian theatres at the time, the opera had a triumphant premiere and is considered by many to be the first of the operatic masterpieces of Verdi's middle-to-late career.

Despite Filipino and Indonedian foreign domestic helpers being the ethnic minorities, there are over 273, 609 foreign domestic helpers in Hong Kong, accounting for 4 % of the entire population.

Despite an increasingly unpredictable domestic and international environment, policy making conforms to well established postwar patterns.

Despite the success in domestic cups, Liverpool was 17th in the table over the second half of the season to finish the season eighth, their worst showing in the league since 1994, failing to qualify for Europe's Champions League for a third straight season.

Despite his efforts, he has not been on a title winning first-class domestic team in either the Premier Trophy or the County Championship.

Despite his lengthy stay abroad, Bismarck was not entirely detached from German domestic affairs.

Despite the global financial crisis, the South Korean economy, helped by timely stimulus measures and strong domestic consumption of products that compensated for a drop in exports, was able to avoid a recession unlike most industrialized economies, posting positive economic growth for two consecutive years of the crisis.

Despite U. S. pressure on Japan to assist America in Iraq, Japan limited their involvement in the war to financial contribution primarily because of domestic opposition to the deployment of troops.

Despite the foreign and domestic difficulties during his reign, which culminated in the fall of Constantinople and of the Byzantine Empire, contemporary sources generally speak respectfully of the Emperor Constantine.

Despite its decline in domestic architecture, the term parlour continues to have an afterlife in many places as common nomenclature for certain categories of commercial enterprise.

Despite financial problems preventing new signings and curtailing squad size, the 2009-10 season saw Rangers reach their fifth consecutive domestic final.

Despite a harsh clampdown against conspiring Roman Catholics, Mary ( in domestic exile and Elizabeth's prisoner for nearly twenty years ), inspires an earnest attempt to overthrow Elizabeth.

Despite financial difficulties in the domestic market, Borders continued to expand its franchises, adding stores in Malaysia, Oman and Sharjah.

Despite its 1960s design, this new domestic terminal can handle more passengers than the more modern but smaller previous domestic terminal.

Despite domestic club troubles, he continued to make progress at international level, scoring the winning goal for the England Under-21 side in a 3 – 2 win over Switzerland.

" Despite increasing recognition that domestic labor is work, existing vocabularies do not easily convey the new appreciations.

Despite the political realignments and hope for more orderly government, domestic economic crises plagued whichever party held power.

Despite this, the widespread perception of " marine products " as " tough " led to domestic outdoor varnishes being branded as " Spar varnish " and sold on the virtue of their weather-and UV-resistance.

Despite a flirtation with the Spanish succession prior to the Franco-Prussian War of 1870 – 71, Luís's reign was otherwise one of domestic stagnation as Portugal fell ever further behind the nations of western Europe in terms of public education, political stability, technological progress and economic prosperity.

Despite his domestic troubles Robert decided to intervene in the civil war in Flanders between Baldwin V, Count of Flanders and his father Baldwin IV whom the younger Baldwin had driven out of Flanders.

Despite their weight, wild turkeys, unlike their domestic counterparts, are agile fliers.

Despite this success against an attack containing both McGrath and Shane Warne, Laxman apparently decided that he would return to domestic cricket, rather than continue playing as opener, a role which he believed did not suit him.