During the first half of the nineteenth century, scientists realized that organic compounds can be synthesized in the laboratory.

During the first half of the nineteenth century, continuing conflicts between the Lakota and Chippewa along the Red River slowed European-American settlement.

During the first half of the nineteenth century, the Chippewa had continued conflicts with the Lakota along the Red River, finally pushing them into present-day western North and South Dakota.

During the first half of the nineteenth century, Wivenhoe Hall was the home of William Brummell, brother of the more famous Beau Brummell.

During the first half of the nineteenth century, as many as one million enslaved African Americans were taken there in a forced migration to work as laborers for the region's cotton plantations.

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