* Early endosomes are the first station of the endocytic pathway.

Early endosomes ( E-labeled for EGFR, 5 minutes after internalisation, and transferrin ), late endosomes / MVBs ( M ) and lysosomes ( L ) are visible.

Early endosomes then mature into late endosomes before fusing with lysosomes.

Early endosomes mature in several ways to form late endosomes.

* Early endosomes consist of a dynamic tubular-vesicular network ( vesicles up to 1 µm in diameter with connected tubules of approx.

Early study on sorting of acid hydrolases such as carboxypeptidase Y ( CPY ) in S. cerevisiae mutants has led to the identification of retromer in mediating the retrograde trafficking of the pro-CPY receptor ( Vps10 ) from the endosomes to the TGN.

Early examples of attempts to capture the phenomenon of motion drawing can be found in paleolithic cave paintings, where animals are depicted with multiple legs in superimposed positions, clearly attempting to convey the perception of motion.

There are large gaps in the fossil record but the discovery of a proto-frog from the Early Permian in Texas in 2008 provided a missing link with many of the characteristics of modern frogs.

Although the fossils of several older proto-frogs with primitive characteristics are known, the oldest " true frog " is Prosalirus bitis, from the Early Jurassic Kayenta Formation of Arizona.

Early experiments are often designed to provide mean-unbiased estimates of treatment effects and of experimental error.

Early human settlements are believed to have been established on Achill around 3000 BC.

Ideas and tenets of Zoroastrian schools of Early Persian philosophy are part of many works written in Middle Persian and of the extant scriptures of the zoroastrian religion in Avestan language.

At the coastal side of the city there are indications of an Early Christian basilica with mosaic floors decorated with semi-precious stones.

Early uses of the term are in Erik Mueller's 1987 Ph. D. dissertation and in Eric Raymond's 1991 Jargon File.

Early board games represented a battle between two armies, and most current board games are still based on defeating opposing players in terms of counters, winning position or accrual of points ( often expressed as in-game currency ).

Early fossils are mainly of erect forms, but encrusting forms gradually became dominant.

" Early episodes with the controversial content intact are rare, and are traded on homemade video recordings made from the original broadcasts.

Early sources are not clear but various groups of Christian communities would have had a group of college or presbyter-overseers functioning as leaders of the local churches.

Early understanding of the functioning of balance of trade informed the economic policies of Early Modern Europe that are grouped under the heading mercantilism.

All of the earliest chordate fossils have been found in the Early Cambrian Chengjiang fauna, and include two species that are regarded as fish, which implies they are vertebrates.

Early markings from this period found on pottery and shells are thought to be ancestral to modern Chinese characters.

The Cantigas are frequently recorded and performed by Early Music groups, and quite a few CDs featuring music from the Cantigas are available.

The Apostolic Canons or Ecclesiastical Canons of the Same Holy Apostles is a collection of ancient ecclesiastical decrees ( eighty-five in the Eastern, fifty in the Western Church ) concerning the government and discipline of the Early Christian Church, incorporated with the Apostolic Constitutions which are part of the Ante-Nicene Fathers

On TV shows based in Chicago such as The Bob Newhart Show, Married ... with Children, Family Matters, Still Standing, According to Jim, Early Edition and The Bernie Mac Show, the main characters are all Bears fans, and have worn Bears ' jerseys and t-shirts on some occasions.

* Early works in the timeline include neologisms which are not explained to any great extent, but serve to produce an atmosphere of strangeness.

However, despite earlier concepts of a strict Early Historic evolution, Irish excavations are increasingly uncovering examples which date to the ' missing ' Iron Age in Ireland.

The term dagger is coined in this time, as are the Early Modern German equivalents dolch ( tolch ) and degen ( tegen ).

Early BBSes were often a local phenomenon, as one had to dial into a BBS with a phone line and would have to pay additional long distance charges for a BBS out of the local calling area.

Early piano music was light in texture, often with Alberti bass accompaniment, but it later became richer, more sonorous and more powerful.

Early personal computer games often needed a keyboard for gameplay, or more commonly, required the user to buy a separate joystick with at least one button .< ref >* Patrick Stack.

Early daily strips were large, often running the entire width of the newspaper, and were sometimes three or more inches high.

Early pre-bluegrass traditional music was often accompanied by the cello.

Samarrai, however, also advises to handle this theory with care, as Medieval and Early Modern Muslim scribes often used etymologically " fanciful roots " in order claim the most outlandish things to be of Arabian or Muslim origin.

Early medieval writers often had fuzzy and imprecise impressions of both Ptolemy and Aristotle and relied more on Pliny, but they felt ( with one exception ), little urge to assume flatness.

Early multi-barrel guns were approximately the size and weight of artillery pieces, and were often perceived as a replacement for cannon firing grapeshot or canister shot.

" Early redemption penalties " were ( and still are ) often based on a penalty of x months of interest / payment ; again no real bar to paying off what had been a large loan.

Early styles of karate are often generalized as Shuri-te, Naha-te, and Tomari-te, named after the three cities from which they emerged.

Since the Early Modern period, the title of knight is purely honorific, usually bestowed by a monarch, as in the British honours system, often for non-military service to the country.

* Provision of benefits to members: Early trade unions, like Friendly Societies, often provided a range of benefits to insure members against unemployment, ill health, old age and funeral expenses.

Early lyrics drew on the band's blues and folk roots, often mixing lyrical fragments from different songs.

In the 19th century, the entire Middle Ages were often referred to as the " Dark Ages ", but with the creation of these subdivisions use of this term was restricted to the Early Middle Ages, at least among historians.

Early heavy machine guns were often water-cooled ; while very effective, the water also added considerable weight to an already bulky design.

Early multi-barrel guns were approximately the size and weight of contemporary artillery pieces, and were often perceived as a replacement for cannon firing grapeshot or canister shot.

Early MUMPS programmers would often store a structure of related information as a delimited string, parsing it after it was read in ; this saved disk access time and offered considerable speed advantages on some hardware.

Early science fiction about Mars often involved the first voyages to the planet, sometimes as an invasion force, more often for the purposes of exploration.

Early inhabitants are often associated with the historical Dilmun Civilisation though the historical records of Dilmun are scanty.

Early contact was often charged with tension and emotion, but also had moments of friendship, cooperation, and intimacy.

Early folk song collectors also often collected ( what were now known as ) nursery rhymes, including in Scotland Sir Walter Scott and in Germany Clemens Brentano and Achim von Arnim in Des Knaben Wunderhorn ( 1806 – 1808 ).