However, the activation energy can be lowered ( and the isomerization catalyzed ) by changes that favor the single-bonded form, such as placing the peptide group in a hydrophobic environment or donating a hydrogen bond to the nitrogen atom of an X-Pro peptide group.

However, not all prolines are essential for folding, and protein folding may proceed at a normal rate despite having non-native conformers of many X-Pro peptide bonds.

However, Astbury did not have the necessary data on the bond geometry of the amino acids in order to build accurate models, especially since he did not then know that the peptide bond was planar.

However, not all peptide groups have the same effect on folding ; nonnative isomers of other peptide groups may not affect folding at all.

However, additional molecular interactions may render the amide form less stable ; the amino group is expelled instead, resulting in an ester ( Ser / Thr ) or thioester ( Cys ) bond in place of the peptide bond.

However, the presence of a peptide in the binding domain stimulates the ATPase activity of Hsp70, increasing its normally slow rate of ATP hydrolysis.

However, as soon as the pH within the endosome drops to about 6. 0, the original folded structure of the HA molecule becomes unstable, causing it to partially unfold and release a very hydrophobic portion of its peptide chain that was previously hidden within the protein.

However, recent research indicated that a protein naturally found in oats ( avenin ) possessed peptide sequences closely resembling wheat gluten and caused mucosal inflammation in significant numbers of celiac disease sufferers.

However, for successful MS analysis the peptide should be enriched within the sample.

However, small-molecules based on a CD36-binding peptide sequence from TSP1 are being tested.

However, the method was not conducive to quantitative comparisons, so Zuckerkandl began working on the determination of the actual peptide sequence of the α and β chains of human and gorilla hemoglobin.

However, if the child has been constantly surrounded, during nursery and early school age, by peer groups ; ;

However, this division into two groups is considered by some modern scholars to be too simplistic and often it is practically impossible to know whether a lyric composition was sung or recited, or whether or not it was accompanied by musical instruments and dance.

However, their overall world view is rejected by groups such as Peoples Global Action and anti-fascist groups such as ANTIFA.

However, the problem is being addressed by community organizations and city government: Trees Atlanta, a non-profit organization founded in 1985, has planted and distributed over 75, 000 shade trees in the city, while Atlanta ’ s government has awarded $ 130, 000 in grants to neighborhood groups to plant trees.

However, the exact placement of the linkage can vary and the orientation of the linking functional groups is also important, resulting in α-and β-glycosidic bonds with numbering definitive of the linking carbons ' location in the ring.

However, attention is still given to these groups by botanists, and fungi ( including lichens ), and photosynthetic protists are usually covered in introductory botany courses.

However, some cultural groups have sought to revive the custom at Uisneach and perhaps at the Hill of Tara.

However, most Republicans did not make a distinction, and " Black and Tans " was often used as a catch-all term for all police and army groups.

However, rivalry between Hadjerai, Zaghawa and Gorane groups within the government grew in the late 1980s.

However, there is debate ongoing between groups that believe the evidence indicates substantial extinction of these species at the K – T boundary, and those who believe the evidence supports multiple extinctions and expansions through the boundary.

However, all non-neornithean birds became extinct, including flourishing groups like enantiornithines and hesperornithiforms.

However, Hertwig confirmed his observation in other animal groups, e. g., amphibians and molluscs.

However, studies of mitochondrial DNA show that the divergence between each of the three chipmunk groups is comparable to the genetic dissimilarity between Marmota and Spermophilus.

However, the combined effects of ethnic and religious fractionalization, i. e. the more chance that any two randomly chosen people will be from separate ethnic or religious groups the less chance of a civil war, were also significant and positive, as long as the country avoided ethnic dominance.

However, in several European countries with civil law, as opposed to the Anglo-American common law system, changes have been made in recent years that allow consumer organizations to bring claims on behalf of large groups of consumers.

However, the Mongol invasion left Korea in disarray and anomie, and these groups became nomadic.

However, by 1704 the Province of Pennsylvania had grown so large that their representatives wanted to make decisions without the assent of the Lower Counties and the two groups of representatives began meeting on their own, one at Philadelphia, and the other at New Castle.

Because reported AIDS cases in Africa and other parts of the developing world include a larger proportion of people who do not belong to Duesberg's preferred risk groups of drug addicts and male homosexuals, Duesberg writes on his website that " There are no risk groups in Africa, like drug addicts and homosexuals ," However, many studies have addressed the issue of risk groups in Africa and concluded that the risk of AIDS is not equally distributed.

However, different groups of birds vary greatly in their sensitivity to these chemicals.

However, within the wide range of Christianity, there are dissenting views from opposing groups, some of which are Complementarians and Patriarchalists.

However, such groups tend not to " burn out " and to sustain for long periods, even generations, protecting the same local treasures.

However, the differences between the various groups that make up the modern environmental movement tend to outweigh such similarities, and they rarely co-operate directly except on a few major global questions.

However, they also tend to be vitamin fortified.

However, when a national trade imbalance expands beyond prudence ( generally thought to be several percent of GDP, for several years ), adjustments tend to occur.

However, if neither the central object nor the surrounding ring were absolutely rigid then the parts of one or both of them would tend to fly out from the axis of rotation.

However, other professionals that play a more peripheral role in the field of professional sports ( e. g. coaches, general managers, referees, commentators and announcers, sports team owners and executives, sports commissioners ) who are more active in the internal aspects of field tend to remain in obscurity and are less likely to achieve celebrity status.

However, an open disk is not compact, because a sequence of points can tend to the boundary without getting arbitrarily close to any point in the interior.

However, others tend to use the term more broadly to include any topics at the intersection of ethics and psychology ( and philosophy of mind ).

However, they tend to greatly lengthen campaigns, and make dissolving the legislature ( parliamentary system ) more problematic if the date should happen to fall at time when dissolution is inconvenient ( e. g. when war breaks out ).

However, it should be noted that because of risks associated with oxygen toxicity, divers tend not to utilize nitrox at greater depths where more pronounced narcosis symptoms are more likely to occur.

* However, Gibbon also calls Eusebius the ' gravest ' of the ecclesiastical historians: " The gravest of the ecclesiastical historians, Eusebius himself, indirectly confesses, that he has related whatever might redound to the glory, and that he has suppressed all that could tend to the disgrace, of religion.

However, data now show that while people of East Asian origin may often have smaller bodies, they tend to have larger brains and higher IQs than average whites.

However, their flippers tend to be proportionately longer, their pelage tends to be darker and the vibrissae more prominent.

However, public opening hours tend to be much longer than most other retailers, with stores open well into the evening in many countries.

However, the clinical literature is very clear that patients whose basal insulin requirements tend not to vary throughout the day or do not require dosage precision smaller than 0. 5 IU, are much less likely to realize much significant advantage of pump therapy.

However, in contrast to linguists, many ordinary Japanese people tend to consider the Ryūkyūan languages as dialects of Japanese.

However, the leading critical opinions of Tristram Shandy tend to be markedly polarised in their evaluations of its significance.

However, modern-day scholars tend to be more suspicious of comparative approaches, avoiding overly general or universal statements about mythology.

However, the American Institute of Biological Sciences also notes bones of dead elephants, left on the ground and subsequently trampled by other elephants, tend to bear marks resembling butchery marks, which have previously been misinterpreted as such by archaeologists.

However, they are not superior in all ways, as neodymium-based magnets lose their magnetism at high temperatures and tend to rust, while samarium-cobalt magnets do not.

However, the relevance of this observation to bone density is unclear, since higher protein diets tend to increase absorption of calcium from the diet and are associated with higher bone density.

However, shot noise in the raw data is prominent in the reconstructed images and areas of high tracer uptake tend to form streaks across the image.

However, heel champions often find advantages, not in Champion's Advantage, but in the use of weapons and outside interference, as these poly-sided matches tend to involve no holds barred rules.

However when the economy starts to recover and the bottom of the market has passed ( sometimes identified on charts as a MACD ), growth stocks tend to recover faster.