However, gene tests may not detect every mutation associated with a particular condition because many are as yet undiscovered.

However, this assumes that such a mutation is possible.

However, the concept of suppressing mutation raises the question: How can design evolution occur at the nanoscale without a process of random mutation and deterministic selection?

However, if we know an object has only one reference ( as most do in many systems ), and that reference is lost at the same time that a similar new object is created ( as in the string append statement ), we can replace the operation with a mutation on the original object.

However, the heterozygous advantage hypothesis was proposed in one review in which the author himself writes, " Although cellular / molecular evidence presently is not available for this hypothesis, the CF mutation may be one of several mutations that have spread in European populations because they increased resistance to infectious diseases.

However, given the scarcity of fertile androgen insensitive men and low incidence of AR mutation, the chances of this occurrence is small.

However, it is interesting to note that premature menopause is more common in premutation carriers than in women with the full mutation, and for premutations with more than 100 repeats the risk of FXPOI begins to decrease.

However, females with a full mutation are able to pass this full mutation on, so theoretically there is a 50 % chance that a child will be affected.

However, " Gaspé " may instead be a mutation of the Basque word " Gerizpe ", meaning " shelter ".

However, Segerer ( 2010 ), the only classification since Sapir, ties Bijago to the Bak languages, based on previously unrecognized sound correspondences, and separates Bak, the rest of Northern ( Senegambian, defined by consonant mutation ), and Mel as independent branches, and Gola and Limba as Niger – Congo isolates.

However, if a mutation affected younger individuals, selection against it would be strong.

However the mutation rate of FOXP2 is slower in the human lineage than in the lineage before the human-chimpanzee split, and proposed that purifying selection would not have relaxed due to negative deleterious effects.

5-10 % of patients with hemophilia A are affected because they make a dysfunctional version of the factor VIII protein ( qualitative deficiency ), while the remainder are affected because they produced factor VIII in insufficient amounts ( quantitative deficiency ).< sup >: 1700 </ sup > Of those who have severe deficiency ( defined as < 1 % activity of factor VIII ), 45-50 % have the same mutation, an inversion within the factor VIII gene that results in total elimination of protein production .< sup >: 1700 </ sup > However, since both forms of hemophilia can be caused by a variety of different mutations, initial diagnosis and classification is done by measurement of protein activity rather than by genetic tests, though genetic tests are recommended for testing of family members once a known case of hemophilia B is identified .< sup >: 1700-1701 </ sup >

However, good functional language compilers will often recognize when an object very similar to an existing one is created and then the old one thrown away, and will optimize this into a simple mutation " under-the-hood ".

However this fast evolution might also be due to these sequences ' inability to repair DNA damage via template-assisted repair which is equivalent to an increase in the mutation rate for these sequences.

However, unlike animal chimeras, both types of tissues may have originated from the same zygote, and the difference is often due to mutation during ordinary cell division.

However, some clones of Pinot Meunier have been found to be completely hairless -- a chimeric mutation, in fact -- which has led ampelographers to more closely draw a link between Meunier and Pinot noir.

However, the difference is subtle and cannot be used to identify the mutation clinically.

However, a study by Negoro et al ( 2006 ) found that a frameshift mutation was unlikely to have been the cause and that rather a two amino acid substitution in the catalytic cleft of an ancestral esterase amplified Ald-hydrolytic activity.

However, few cases of lipoid CAH due to a mutation and defect of P450scc have been identified.

However, even after millions of years of evolution, exploring many sequences with similar function, no mutation might exist that gives this enzyme the ability to catalyze a different reaction.

However, her mind is later completely circumvented by the mutation.

However, the same mutation also conveyed advantages, providing improved viability for heterozygous individuals.

However, for convenience we will stick to the idea that information can be classified according to Table 1.

However, the surface temperature gradient can produce erroneous vapor-pressure measurements for the bulk liquid helium unless precautions are taken to isolate the tube ( which passes through the surface to the vapor pressure bulb ) from the liquid helium surface.

However, the healthy inventory position of the textile industry lends support to the broadly expressed belief that improvement in that industry can be expected by the second half of 1961.

However, it is essential that the various mathematical symbols used in the equations be understood so that the mathematical processes can be done properly and in their correct order.

However, the displacement of the cylinder can be converted to cubic centimeters.

However, the formation of organically bound iodine, mainly mono-iodotyrosine, can be accomplished in cell-free systems.

However, the leveling operation can be maintained and controlled remotely with no mechanical or optical contact with the platform.

However, this difficulty is not too serious if it is realized that a surveying team can establish a true north base line with a few days' work.

However, the teacher can only go so far if the attitude of the community and the family is anti-intellectual.

However, one can argue that no such control is necessary as long as one pretends that the anti-trust laws are effective and rational.

However much we may have to criticize liberal theology's constructive formulations, the theology we ourselves must strive to formulate can only go beyond liberalism, not behind it.

However, many consequences of treatment-unit additivity can be falsified.

However, certain critical interlocutory court orders, such as the denial of a request for an interim injunction, or an order holding a person in contempt of court, can be appealed immediately although the case may otherwise not have been fully disposed of.

However, no direct connection can be demonstrated, and the similarity of the abaci may be coincidental, both ultimately arising from counting with five fingers per hand.

However, such apparent simplifications can perversely make a script more complicated.

However, the opposite can also be true-An opponent can turn a positive statement into a bad one, if the speaker uses ambiguity ( intentionally or not ).

However, many DSCs, and also go-to systems, can work in conjunction with laptop sky programs.

However, it was held by the Supreme Court that an affidavit can be used as an evidence only if the Court so orders for sufficient reasons.

However, non-arable land can sometimes be converted into arable land.

However, anxiety should not be confused with fear, it is more of a dreaded feeling about something which appears intimidating and can overcome an individual.

However a comparable performing digital system is more complex and can require more bandwidth than its analog counterpart.

However, in digital systems, degradation can not only be detected but corrected as well.

However, the algorithm can be improved by adopting the method of the assumed mean.

However, some alloys can also have their properties altered by heat treatment.