However, once Ca < sup > 2 +</ sup > signaling in the mitochondria passes a certain threshold, it stimulates the intrinsic pathway of apoptosis in part by collapsing the mitochondrial membrane potential required for metabolism.

However, some cell lines — in particular, primary cultures of quiescent and differentiated cells such as thymocytes and neurons — are prevented from undergoing apoptosis on exposure to proteasome inhibitors.

However, when glutamate molecules in the synaptic cleft cannot be degraded or reused, often due to dysfunction of the glutamate-glutamine cycle, the neuron becomes significantly overstimulated, leading to a neuronal cell death pathway known as apoptosis.

However, more severe oxidative stress can cause cell death and even moderate oxidation can trigger apoptosis, while more intense stresses may cause necrosis.

However, owing to the conflicting and variable nature of studies into the role of ceramide in apoptosis, the mechanism by which this lipid regulates apoptosis remains elusive.

However, spies and others whose secrets must be guarded may have an induced allergy to fast-penta and rare few people are naturally allergic ; in both cases using the drug on allergic person results in rapid death from anaphylactic shock.

However, the Soviet threat of seizing parts of Inner Mongolia induced China to recognize Outer Mongolia's independence, provided that a referendum was held.

However, the observable anatomical subdivisions of the dorsal striatum ( caudate nucleus and putamen ) essentially induced by the internal capsule do not completely overlap with now accepted anatomo-functional subdivisions.

" However, in January 1973, former Illinois Racing Board Chairman William S. Miller testified that Daley had " induced " him to bribe Illinois Governor Otto Kerner.

However, later studies have addressed the application of CIMT for children with CP challenged with hemiparesis, that show a significant benefit in constraint induced movement therapy for children with cerebral palsy who are challenged with hemiparesis.

However, increased dosage raises increase the adverse side effects, including the risk of radiation induced cancer — a four-phase abdominal CT gives the same radiation dose as 300 chest x-rays ( See the Scan dose section ).

However, it was quickly realized that it was an electrical current that is induced, which by Ampere's law deflects the magnet.

However, when they are highly concentrated in the photophore ( about cells / ml ), transcription of luciferase is induced, leading to bioluminescence.

However, hydrogenation is unfortunately associated with light induced degradation of the material, termed the Staebler-Wronski Effect.

However chronic inflammation induced by the bacteria causes further reduction of acid production and, eventually, atrophy of the stomach lining, which may lead to gastric ulcer and increases the risk for stomach cancer.

However, excess drainage results in recurring drought induced crop yield losses and more severe urban heat or desiccation issues.

However in urban areas, the extinguishing of fires ignited by thermal radiation may matter little, as fires may also be started in a surprise attack by blast effect induced electrical shorts, gas pilot lights, overturned stoves, and other ignition sources, as was the case in the breakfast-time bombing of Hiroshima.

However, talks to renew that coalition failed, which induced Schüssel to enter a coalition with the Freedom Party.

However, studies of supplementation with large doses of β-carotene in smokers have shown an increase in cancer risk ( possibly because excessive β-carotene results in breakdown products that reduce plasma vitamin A and worsen the lung cell proliferation induced by smoke ).

However, an elliptical planform is more efficient as the induced downwash ( and therefore the effective angle of attack ) is constant across the whole of the wingspan.

However, in freezing conditions, it may be that for very small birds, including the tiny Goldcrest, the energy economies of induced hypothermia may be insufficient to counterbalance the negative effects of hypothermia including the energy required to raise body temperature back to normal at dawn.

However, the gradual climate change over the centuries, accelerated by human induced evaporation of the Aral Sea in the late 20th century has created an apocalyptic scene in the region.

However, as speed increases the induced drag becomes much less, but parasitic drag increases because the fluid is flowing faster around protruding objects increasing friction or drag.

However, despite the concept of induced traffic now being accepted, it is not always considered.

However, HOV lanes which are additional to existing capacity do result in an induced rise in overall traffic, because the shift of HOVs to the new lane releases capacity in the existing lanes, reducing the generalised cost of journeys in those lanes and thus increasing demand.

However, like other forms of radioactive decay, it occurs due to quantum tunneling, without the atom having been struck by a neutron or other particle as in induced nuclear fission.

However it does not explain mechanically induced itch or when itch is produced without a flare reaction which involves no histamine.

However when they induced noxious counterstimuli, there was a significant inhibition of itch for an extended period of time but no inhibition of pain.

However the greatest bradycardia effect is induced when the subject is holding breath with face submerged.

However, I confess my hope that I will be innocent again, not with a pristine, accidental innocence, but rather with an innocence achieved by the slow cutting away of the flesh to reach the bone.

However, by comparing the TV snatches, two different radio station re-runs, and the censored Los Angeles Times version, I found that the radio stations had edited out questions ( ABC removed the one regarding Laos ) or even a paragraph out of the middle of the President's answer.

However, the litter remained, augmented by several dozen lunchroom suppers.

However, the healthy inventory position of the textile industry lends support to the broadly expressed belief that improvement in that industry can be expected by the second half of 1961.

However, there is also much to be gained by making use of the abilities of the local people who are available and interested in recreation.

However, technical difficulties arise by melting at local hot spots.

However, they do demonstrate the presence of large normal pressures in the presence of flat shear fields which were forecast by the theory in the first part of the paper.

However, there are photographs of suspended drops of cyclohexanol phthalate ( viscosity 155 poises ) suspended in corn syrup of 71 poises in a paper by Mason and Bartok.

However, one must expect that vaporization and ejection of material by hypervelocity impacts would cause a deviation from a linear relationship.

However, the nonspecific staining by the Af in tumor sections was considered bright enough to be confused with the staining of small amounts of WTV antigen.

However, there was no real question of the justice of creating a strong Poland, both industrially and agriculturally, and one unplagued by large minorities of Germans or Russians.

However, as witnessed by the large corporate bond calendar at present, as well as the record amount of municipal bond issues approved by voters, the over-all demands for capital funds seem likely to remain high, so that any downward pressure on rates from reduced demand should not be great.

However, it is not known to either the union or the public precisely how much of a cost increase is caused by a given change in the basic wage rate, although the companies are presumed to have reliable estimates of this magnitude.

However, in the actual assessment of the cutting force by instrumental methods for any thickness of coating a number of spurious effects occur which must be taken into account and which make the measured value larger than the true cutting force indicated by eqn. ( 1 ).

However, a growing intellectual sophistication and the new certitudes imparted by courses in psychology and anthropology make the students increasingly critical of their somewhat provincial and overprotective parents.

However, by cultivating a wine dealer and accepting his advice, one will soon enough ascertain whether he has any knowledge of wines ( as opposed to what he may have been told by salesmen and promoters ) and, better yet, whether he has a taste for wine.

However much football has been over-emphasized, the public likes to measure its collegiate favorites by the scoreboard, so, while Yale need never give its record a thought again since outscoring its opponents 694 to 0 in the season of 1888, Dartmouth had to wait until its championship team of 1925 for national recognition.

However, if the child has been constantly surrounded, during nursery and early school age, by peer groups ; ;

However, she really does not know how to match the quantity of dollars given away by a quality of leadership that is basically needed.

However, at the same time Montgomery selects as his hero De Gaulle, who is a militarist dominated by political ambitions.

However, Plato reports that syntax was devised before him, by Prodicus of Ceos, who was concerned by the correct use of words.