However, some cell lines — in particular, primary cultures of quiescent and differentiated cells such as thymocytes and neurons — are prevented from undergoing apoptosis on exposure to proteasome inhibitors.

However, it is also a fundamental step in the transition of tumors from a dormant state to a malignant one, leading to the use of angiogenesis inhibitors.

However, the most severe decreases in sexual desire relating to psychiatric medication occur due to the use of selective serotonin reuptake inhibitors ( SSRIs ).

However, improvements in amino acid composition, B-group vitamins, sugars, protein and starch digestibilities, and decrease in phytates and protease inhibitors are the metabolic effects of the sprouting process .”

However, the label of all three PDE5 inhibitors was changed to alert clinicians to a possible association.

However, EGW solutions formulated for the automotive industry often have silicate based rust inhibitors that can coat and / or clog heat exchanger surfaces.

However, a more recent study suggested that prophylaxis with proton pump inhibitors along with clopidogrel following acute coronary syndrome may increase adverse cardiac outcomes, possibly due to inhibition of CYP2C19, which is required for the conversion of clopidogrel to its active form.

However, several cardiologists have voiced concern that the studies on which these warnings are based have many limitations and that it is not certain whether there really is an interaction between clopidogrel and proton pump inhibitors.

However, 5α-reductase inhibitors are thought to have persistent side effects that can continue after quitting the treatment, including diminished libido, erectile dysfunction and male breast cancer, and are suspected to have persistent cognitive side effects, including depression, brain fog and memory loss ..

However, a growing consensus among researchers of smoking cessation have found nicotine replacement therapy ( NRT ) products to be minimally effective because tobacco users are often seeking the combination of MAO inhibitors ( which are found in tobacco ) and nicotine.

However, Angiotensin converting enzyme inhibitors and Angiotensin II receptor antagonists are favoured due to their anti-proteinuric effect.

However, if gastroprotective agents continue to be coprescribed along with COX-2 inhibitors, there would seem to be no advantage to the use of these higher cost NSAIDs.

However, selective serotonin reuptake inhibitors ( SSRIs ) can help manage underlying problems.

However, not all inhibitors that bind at allosteric sites are mixed inhibitors.

However, despite its structural similarity to DMT it is active orally around 50 – 100 mg without the aid of MAO inhibitors lasting about 2 – 4 hours.

However the selectivity of the existing drugs is high enough that inhibition of additional PDE subtypes is not generally a problem in clinical use, and while newer " super-selective " PDE5 inhibitors have been developed for research purposes, it is unlikely any of these will be marketed given the saturation of the erectile dysfunction market at present.

However, most men have a cause for their ED as noted by the history and physical examination and the laboratory tests and PDE-5 inhibitors are the first line of choice.

However, ACE inhibitors and pimobendan have different mechanisms of action, and many veterinary cardiologists recommend they be used concurrently.

However, only a minority of patients respond to corticosteroids alone, so additional immunosuppressants, such as cyclophosphamide, azathioprine, methotrexate, penicillamine, and cyclosporine may be used.

However, Ancient Egyptian is highly divergent from Proto-Afroasiatic ( Trombetti 1905: 1 – 2 ), and considerable time must have elapsed in between them.

Experiments have been conducted to attempt the synthesis of ununennium ( Uue ), which is likely to be the next member of the group, but they have all met with failure .< ref name =" link "> However, ununennium may not be an alkali metal due to relativistic effects, which are predicted to have a large influence on the chemical properties of superheavy elements.

However, algorithms are also implemented by other means, such as in a biological neural network ( for example, the human brain implementing arithmetic or an insect looking for food ), in an electrical circuit, or in a mechanical device.

However, as has been pointed out by Alexis Manaster Ramer and Paul Sidwell ( 1997 ), Strahlenberg actually opposed the idea of a closer relationship between the languages which later became known as " Altaic "..

However, other versions of her myth have her born near the island of Kythira ( Cythera ), for which reason she is called " Cytherea ".

However, very small amounts of steel, ( an alloy of iron and around 1 % carbon ), was always a byproduct of the bloomery process.

However, this did not explain similarities between different atoms, as expressed by the periodic table, such as the fact that helium ( 2 electrons ), neon ( 10 electrons ), and argon ( 18 electrons ) exhibit similar chemical behavior.

However, much of southeastern Europe and central Europe, including many of the Goths and Vandals respectively, had embraced Arianism ( the Visigoths converted to Arian Christianity in 376 ), which led to Arianism being a religious factor in various wars in the Roman Empire.

However, there are certain limitations: they may not administer the sacraments and related functions whose celebration is reserved to bishops, priests, deacons, or seminarians ( the male clergy ), namely, Holy Orders ( they may make provision for an ordained cleric to help train and to admit some of their members, if needed, as altar servers, Eucharistic ministers, or lectors-the minor ministries which are now open to the non-ordained ).

However, later that month, on 22 January, the English were defeated at the Battle of Basing and, on the 22 March at the Battle of Merton ( perhaps Marden in Wiltshire or Martin in Dorset ), in which Æthelred was killed.

However, his aptitude for sculpture led him to work for Giulio Cesare Conventi ( 1577 — 1640 ), an artist of modest talents.

However, there are notable exceptions to this in all major translations, such as: “… I am with you always, to the end of the age ” ( NRSV ), the word “ age ” being a translation of aion.

However, British pubs and restaurants often supply larger quantities ( large glass ≈ 250 ml ), which contain 3 units.

* However, a larger 35ml measure is increasingly used ( and in particular is standard in Northern Ireland ), which contains 1. 4 units of alcohol.

However, since Paul was from Cilicia and refers to himself using this name ( see Acts 21: 39, 22: 3 ), it seems very natural that the name Cilicia would have continued to be in colloquial use among its residents despite its hiatus in official Roman nomenclature.

However, the presence of a vigorous population of Celtic lineage, principally of Irish origin, has supported the creation of other celebrations of beer, often for marketing purposes, such as Saint Patrick's Day ( Día de San Patricio ), patron of Ireland, which is celebrated with abundant libations.

However, when, under manager Jack Kirwan, the club got promoted to the top flight of Dutch football for the first time in 1911 ( then the Eerste Klasse or ' First Class ', later named the Eredivisie ), Ajax were forced to change their colours because Sparta Rotterdam already had exactly the same outfit.

However, the Church declared that "' Extreme unction ' ... may also and more fittingly be called ' anointing of the sick '" ( emphasis added ), and has itself adopted the latter term, while not outlawing the former.

However, in 1513 and 1514 Dürer created his three most famous engravings: Knight, Death, and the Devil ( 1513, probably based on Erasmus's treatise Enichiridion militis Christiani ), St. Jerome in his Study, and the much-debated Melencolia I ( both 1514 ).

However, upon immunization with SRBC ( sheep red blood cells ), these mice demonstrated a deficiency in the maturation of an antibody response ; they were able to generate normal levels of IgM, but could not develop specific IgG levels.

However, shortly after this positive result, Kurt Gödel published On Formally Undecidable Propositions of Principia Mathematica and Related Systems ( 1931 ), showing that in any sufficiently strong axiomatic system there are true statements which cannot be proved in the system.

However, invalid formulas ( those that are not entailed by a given theory ), cannot always be recognized.

However, not everyone appreciates his work and River Landscape ( 1660 ), despite being widely regarded as amongst his best work, has been described as having " chocolate box blandness ".

However, the name Artemis ( variants Arktemis, Arktemisa ) is most likely related to Greek árktos ‘ bear ’ ( from PIE * h₂ŕ ̥ tḱos ), supported by the bear cult that the goddess had in Attica ( Brauronia ) and the Neolithic remains at the Arkouditessa, as well as the story about Callisto, which was originally about Artemis ( Arcadian epithet kallisto ).