However, mutations of the dystrophin gene and nutritional defects ( with no genetics history ) at the prenatal stage are also possible in about 33 % of people affected by DMD.

However, populations of bacteria are large enough that a few individuals will have beneficial mutations.

However, recent research suggests that many mutations in non-coding DNA do have slight deleterious effects.

However, the heterozygous advantage hypothesis was proposed in one review in which the author himself writes, " Although cellular / molecular evidence presently is not available for this hypothesis, the CF mutation may be one of several mutations that have spread in European populations because they increased resistance to infectious diseases.

However, calculations of Y pestiss evolutionary age, found using the number of synonymous single nucleotide polymorphisms ( SNPs ) in conjunction with molecular clock rates, date the emergence of the biovars prior to any of the historical epidemics due to the length of time needed to accumulate such mutations.

However, if most cells in the brain activate the X chromosome with the functional MECP2 allele, the individual will have very mild Rett syndrome ; likewise, if most neurons activate the X chromosome with the mutated MECP2 allele, the individual will have very severe Rett syndrome just as males with MECP2 mutations do ( as they only have one X chromosome ).

However, it is interesting that only specific components of the behavior were affected with the genetic mutations.

However, the experimental work at his lab with Drosophila melanogaster, which helped establish the link between Mendelian genetics and the chromosomal theory of inheritance, demonstrated that rather than creating new species in a single step, mutations increased the genetic variation in the population.

However, many other mutations within RNase MRP also cause CHH.

5-10 % of patients with hemophilia A are affected because they make a dysfunctional version of the factor VIII protein ( qualitative deficiency ), while the remainder are affected because they produced factor VIII in insufficient amounts ( quantitative deficiency ).< sup >: 1700 </ sup > Of those who have severe deficiency ( defined as < 1 % activity of factor VIII ), 45-50 % have the same mutation, an inversion within the factor VIII gene that results in total elimination of protein production .< sup >: 1700 </ sup > However, since both forms of hemophilia can be caused by a variety of different mutations, initial diagnosis and classification is done by measurement of protein activity rather than by genetic tests, though genetic tests are recommended for testing of family members once a known case of hemophilia B is identified .< sup >: 1700-1701 </ sup >

However, cross resistance where mutations confer resistance to two or more treatments can be problematic.

However, its major drawback is that detailed structural knowledge of a protein is often unavailable, and even when it is available, it can be extremely difficult to predict the effects of various mutations.

However, the degree of lifespan extension in relative terms by both the age-1 and daf-2 mutations is strongly dependent on ambient temperature, with ~ 10 % extension at 16 ° C and 65 % extension at 27 ° C.

However, there may be mutations of the disease that can cause ulcers on the exterior.

However, those in the pet industries have, through selective breeding, developed many morphs ( genetic mutations ) with altered colors and patterns.

However, Gilbert's syndrome can arise without TATA box promoter polymorphic mutations ; in some populations, particularly healthy southeast and east Asians, Gilbert's syndrome is more often a consequence of heterozygote missense mutations ( such as Gly71Arg also known as UGT1A1 * 6, Tyr486Asp also known as UGT1A1 * 7, Pro364Leu also known as UGT1A1 * 73 ) in the actual gene coding region, which may be associated with significantly higher bilirubin levels.

However, mutations in these genes account for only 2 to 3 percent of all breast cancers.

However, after a sufficient number of mutations have been fixed in the population, the birth rate is slightly less than the death rate, and the population size begins to decrease.

However, Ray made some key changes to the programming language such that mutations were much less likely to destroy a program.

However, mutations are also triggered, including carcinogenic mutations, explaining the higher incidence of cancer after exposure.

However, heterogametic hybrids, which carry only a single copy of a given sex-linked gene, will be affected by mutations regardless of dominance.

However in organisms containing only one chromosome, deleterious mutations would be eliminated immediately: therefore removal of harmful mutations is an unlikely benefit for sexual reproduction.

However, they require compromises in borderline cases ; for example, nicotine contains a pyridine fragment from nicotinamide and pyrrolidine part from ornithine and therefore can be assigned to both classes.

However, in nuclear reactors, the fission fragment kinetic energy remains as low-temperature heat, which itself causes little or no ionization.

However, no odd-even effect is observed on fragment mass number distribution.

However, the Hesiodic Catalogue of Women, fragment # 5, had made a " Pandora " one of the daughters of Deucalion, and the mother of Graecus by Zeus.

However, simulation studies give a 70 percent probability that the crater was created by a fragment from the same break-up that created asteroid 298 Baptistina ; which was previously believed to be responsible for the formation of Chicxulub Crater and the extinction of the dinosaurs.

However, the comment is preserved as an incomplete fragment and modern scholars are not unanimous in their interpretation of it.

The primary blocking consisted of a wall of cemented limestone blocks, plastered and stamped with the seal of the Royal Necropolis ( with the jackal and nine captives motif ).< ref name =" reeves p. 42 "> Reeves, C. N., < cite > Valley of the Kings </ cite > ( Kegan Paul, 1990 ) p. 42 </ ref > Weigall later stated that a fragment of Tutankhamun's seal had been recovered from this original blocking .< ref > Weigall, A. E. P. B., < cite > The Treasury of Ancient Egypt </ cite > ( Rand McNally and Company, 1912 ) p. 208 </ ref > However, his statement is not corroborated by any of the other reports dating from the initial discovery, leaving Weigall's claim open to question .< ref > Davis, T. M., < cite > The Tomb of Queen Tiyi </ cite >, ( KMT Communications, 1990 ) p. vi .</ ref >< ref > Bell, M. R., < cite >" An Armchair Excavation of KV 55 ", JARCE 27 ( 1990 )</ cite > p. 136 </ ref >

However, a reference to a year 39 on a fragment found in the construction debris of Senusret's mortuary temple has suggested the possibility of a long coregency with his son.

" However, Brier has stated that the bone fragment in the skull is not relevant to the issue of whether Tutankhamun was murdered, acknowledging that it was likely caused by the embalmers.

However, the Liberal Party split on the issue of Irish Home Rule, leading to another general election in 1886 in which the Conservatives were the largest party and were enabled to form a minority government by the fragment of Liberalism opposed to Home Rule, the Liberal Unionist Party.

However, modern systems profit enormously from the huge disk capacities currently available, since partially filled disks fragment much less than full disks, and on a high-capacity HDD, the same partition occupies a smaller range of cylinders, resulting in faster seeks.

However, in the early 1970s Mirella Ferrari found a fragment of the poem, written in either the 7th or 8th century, that preserves the final of 39 lines, and has forced a re-evaluation not only of the text but of its transmission.

However, schisis is a word fragment, and the term retinoschisis should be used, as should the term iridoschisis when describing splitting of the iris.

However, the artifacts were not fully preserved and only one flint blade and a soapstone fragment still exist.

However, the Liberal Party split on the issue of Irish Home Rule, leading to another general election in 1886, in which the Conservatives won the most seats and governed with the support of the fragment of Liberalism opposed to Home Rule, the Liberal Unionist Party.

However, the opera was never completed and only a 20 minute fragment from Act I exists.

However, he misuses the fragment to become more powerful and take over New York's underworld from Osborn.

However, a cautionary note was raised by the discovery that a papyrus fragment in Cologne constitutes part of the Egerton Gospel.

However he does have a sideline in instant temporary structures, such as bleachers and tents, all made of wood with no iron in them, which can be reconstituted from a fragment of an original structure.

However, when the species needs to be determined ( in epidemiological studies, for example ), restriction fragment length polymorphisms can be effectively used.

However, Ioneos's appearance and size are much larger and sleeker than Kuon's because he is an entire crystal, save a small chipped fragment which Kuon is made from.

However these features may be a feature of ontogeny of the single taxon represented by a single skull fragment, and thus these characteristics may not indicate visual acuity in the adults of this taxon, for which no skull has been described.

However, the view of the island as a surviving fragment of the Cretaceous period is obsolete.

However, if the West Saxon kingdom did fragment following Cenwalh's death, it appears that it was reunited during Centwine's reign.

However, it was felt that Bigorre was not large enough to meet the criteria of a département, so it was decided that the province of Quatre-Vallées and a fragment of the province of Nébouzan, both to the east of Bigorre, as well as several areas of Gascony to the north of Bigorre, would be joined with Bigorre to create the new département of Hautes-Pyrénées.