However, ribavirin has proven to have little if any clinical usefulness against HIV, and it can greatly increase blood levels and also toxicity of the HIV antiviral didanosine ( ddI, Videx ).

However, the development of models to predict the mechanisms of membrane fusion will assist in the scientific understanding of how to target the process with antiviral drugs.

However, antiviral medications, such as acyclovir and valacyclovir, are quite effective in prevention of HSCT-related outbreak of herpetic infection in seropositive patients.

However, like antibiotics, viruses may evolve to resist the antiviral drug.

However, brews made using DMT containing plants are illegal since DMT is a Schedule I drug.

However, they are much less toxic than their predecessors, the barbiturates, and death rarely results when a benzodiazepine is the only drug taken ; however, when combined with other central nervous system depressants such as alcohol and opiates, the potential for toxicity and fatal overdose increases.

However, a political crisis relating to large-scale contributions from drug traffickers to Samper's presidential campaign diverted attention from governance programs, thus slowing, and in many cases, halting progress on the nation's domestic reform agenda.

However, after enough carbamazepine has been presented to the liver tissue, the CYP3A4 activity increases, speeding up drug clearance and shortening the half-life.

Because reported AIDS cases in Africa and other parts of the developing world include a larger proportion of people who do not belong to Duesberg's preferred risk groups of drug addicts and male homosexuals, Duesberg writes on his website that " There are no risk groups in Africa, like drug addicts and homosexuals ," However, many studies have addressed the issue of risk groups in Africa and concluded that the risk of AIDS is not equally distributed.

However, evidence came to light about safety concerns with the new drug which caused some insurers to stop funding it even though marketing approval was not withdrawn.

However as a result of intense pressure from the U. S. authorities, widespread efforts are currently being made to introduce systematic anti-money laundering initiatives on a global scale, to better curb the activities of the financiers of terrorism and those engaged in laundering the profits of drug smuggling.

However, some users will bypass this danger by using cold water extraction to extract and dispose of a portion of the paracetamol, taking advantage of the water-soluble element of the drug.

However, this immediately excludes from the market anyone who cannot afford the cost of the product, in this case a life saving drug.

However, before this drug is used in the clinic, it must progress through a series of in vivo trials to determine if it is safe and effective in intact organisms ( typically small animals, primates and humans in succession ).

However, clomethiazole is specifically discouraged for unsupervised home detox because of its addictiveness, its tendency to rapidly induce drug tolerance, and its dangerously high risk of death when mixed with alcohol.

However, dextropropoxyphene is still prescribed for the short term relief of opiate withdrawal symptoms, particularly when the aim of treatment is to smooth detoxification to a drug free state rather than a switch to maintenance treatment.

However, spies and others whose secrets must be guarded may have an induced allergy to fast-penta and rare few people are naturally allergic ; in both cases using the drug on allergic person results in rapid death from anaphylactic shock.

However, seemingly few transcend to becoming problem drug users ( 0. 30 %), well below the average ( 0. 52 %) of the same compared countries.

However, studies by the Drug Abuse Warning Network in the 1970s show that media reports of PCP-induced violence are greatly exaggerated and that incidents of violence were unusual and often ( but not always ) limited to individuals with reputations for aggression regardless of drug use.

However, the new government of president Ernest Bai Koroma quickly amended the laws against drug trafficking in the country, updating the existing legislation from those inherited at independence in 1961, to address the international concerns, increasing punishment for offenders both in terms of higher, if not prohibitive, fines, lengthier prison terms and provision for possible extradition of offenders wanted elsewhere, including to the United States.

However, tricyclic antidepressants still are probably more successful in treating melancholic depression than other antidepressant drug classes.

However, there are a number of institutions specializing only in the treatment of juveniles, particularly when dealing with drug abuse, self harm, eating disorders, anxiety, depression or other mental illness.

However, since 2008 the city has experienced violence related to turf battles between warring drug cartels in Mexico.

However, in a warning letter to a manufacturer of opium tincture in late 2009, the FDA noted that " In regard to your unapproved drugs, we found that your firm is manufacturing and distributing the prescription drug Opium Tincture USP ( Deodorized — 10 mg / mL ).

However, in a subsequent case, the Court held that the Government had not carried the burden under the Religious Freedom Restoration Act of showing a compelling interest that allowed no exception to the ban on the use of the drug to accommodate a sincere religious practice.

However, because dopamine cannot cross the blood – brain barrier, dopamine given as a drug does not directly affect the central nervous system.

However, importation of areca nut in a form other than whole or carved kernels of nuts can be stopped at the discretion of US Customs officers on the grounds of food, agricultural, or medicinal drug violations.

However, a continuing problem remains in effect, as the prohibited drugs continue to be available through illegal trade, see illegal drug trade, also known as the Black Market.

However, in recent decades, for what doubtless are multiple reasons, an unannounced but nonetheless readily observable shift has occurred in both facets of national activity.

However, as a practicing historian, he, himself, has left few clues to the amount of professional scholarship that he used when writing history.

However, it seems axiomatic that the government has an obligation `` to exercise its mandate reasonably, equitably and with full regard for the disruptions which it inevitably causes ''.

However, because this vulnerability is mutual, it is to the advantage of neither side to destroy the opponent's cities, at least so long as the opponent has nuclear weapons with which to effect reprisal.

However, that is not all he has to do.

However, there are relatively few such political constituencies, and, as has been pointed out, there is seldom a clear-cut distinction between the educational interests of one social class and those of another.

However, electrostatic focus, important for many applications, has not been realized for these devices.

However, readers who accept Freud's findings and believe that he has solved completely the mystery of dreams, should ponder over the following words in his Interpretation Of Dreams, Chapter 1::

However, by cultivating a wine dealer and accepting his advice, one will soon enough ascertain whether he has any knowledge of wines ( as opposed to what he may have been told by salesmen and promoters ) and, better yet, whether he has a taste for wine.

However much football has been over-emphasized, the public likes to measure its collegiate favorites by the scoreboard, so, while Yale need never give its record a thought again since outscoring its opponents 694 to 0 in the season of 1888, Dartmouth had to wait until its championship team of 1925 for national recognition.

However, as Erickson has noted, the individual's failure to develop preliminary identities during infancy and childhood need not be irreversibly deterministic with respect to a given area of identity diffusion in his ( or her ) adolescence.

However, if the child has been constantly surrounded, during nursery and early school age, by peer groups ; ;

In a long commentary which he has inserted in the published text of the first act of the play, he says at one point: `` However, that experience never raised a doubt in his mind as to the reality of the underworld or the existence of Lucifer's many-faced lieutenants.

However, while Apollo has a great number of appellations in Greek myth, only a few occur in Latin literature, chief among them Phoebus ( ; Φοίβος, Phoibos, literally " radiant "), which was very commonly used by both the Greeks and Romans in Apollo's role as the god of light.

However, the monophyly of Cabozoa has been refuted and the monophylies of Archaeplastida and Chromalveolata are currently strongly challenged.

However, only a very small percentage of all these people has remained in Angola, either for personal reasons ( intermarriage ) or as professionals ( e. g. medical doctors ).

However, as has been pointed out by Alexis Manaster Ramer and Paul Sidwell ( 1997 ), Strahlenberg actually opposed the idea of a closer relationship between the languages which later became known as " Altaic "..

However, the method has been criticised as containing possible sources of error.

However, metal formation for condensed-phase astatine has also been suggested.

However, astatine has a few metallic characteristics as well, such as plating out on a cathode, coprecipitating with metal sulfides in hydrochloric acid, and forming a cation in strong acidic solutions.

However, the hydrogen-1 atom has no neutrons and a positive hydrogen ion has no electrons.

However, it is the editor who has " the power to impose the dominant definition of the writer and therefore to delimit the population of those entitled to take part in the struggle to define the writer ".

However, this has now been replaced by a more professional exhibition space incorporating laser, video, slide shows, audio commentaries, and some interactive elements.