However, the potential for clozapine to cause toxic side effects, including agranulocytosis, limits its usefulness.

However, technologists such as Bill Joy have warned of the potential power which genetic engineering might place in the hands of future bio-terrorists.

However, they are much less toxic than their predecessors, the barbiturates, and death rarely results when a benzodiazepine is the only drug taken ; however, when combined with other central nervous system depressants such as alcohol and opiates, the potential for toxicity and fatal overdose increases.

However, the Ionian Revolt had directly threatened the integrity of the Persian empire, and the states of mainland Greece remained a potential menace to its future stability.

However, Pedro de Valdivia, captain of the army, realizing the potential for expanding the Spanish empire southward, asked Pizarro's permission to invade and conquer the southern lands.

However, he allowed both Plectrude and the young Theudoald to live and treated them with kindness — unusual for those times, when mercy to a former gaoler, or a potential rival, was rare.

However, the rebellion of Tacfarinas had shown how exposed Africa Proconsularis was to its west and how the Mauretanian client kings were unable to provide protection to the province, and it is thus possible that Caligula's expansion was a prudent response to potential future threats.

However, Khrushchev and Malenkov were able to gather enough support for Beria's ouster, but only when a rumour of a potential coup led by Beria began to take hold within the party leadership.

However, a mulatto who escaped the destruction of Syn's previous ship stowed away in Clegg's ship and accused him before the crew ; Clegg quelled the potential mutiny by having the mulatto's tongue cut out, marooning him on a coral reef and violently killing Yellow Pete, the ship's Chinese cook, who represented the crew in their wish to rescue the mulatto.

However, these potential bite marks were first noticed in photographs years after the trials and were not inspected by a board-certified medical examiner until four years after the murders.

However, the reactions are reversible and the role of a particular electrode in a cell depends on the relative oxidation / reduction potential of both electrodes.

In order for this reaction to occur the power supply should provide at least a potential of 4 V. However, larger voltages must be used for this reaction to occur at a high rate.

However, it was to take another three years, and a change of coach, before the team's obvious potential was translated into tangible success.

However, this is a specific property of hydrogen and is no longer true for more complicated atoms which have a ( effective ) potential differing from the form 1 / r ( due to the presence of the inner electrons shielding the nucleus potential ).

However, some states are the subject of potential irredentism from their inception.

However, in order to not limit potential detainee's freedoms too much it is characterized by the time limit of near future.

However, more recently researchers have brought attention to potential underlying causes of OCBs, including social pressure, coercion, and other external forces.

However, according to Painter unlike the Testimonium this issue has not generated a great deal of controversy, although viewed as a potential reason for doubting authenticity.

However, other scientists have written that " the full potential PCR was not realized " until Mullis ' work in 1983, and that Mullis ' colleagues failed to see the potential of the technique when he presented it to them.

However, it soon became apparent that the Slipstream project had the potential to be much more than a peripheral.

However, there is also significant potential for extremes of hot and cold swings in temperature all year long.

However shielded twisted pair was used in IBM's Token Ring implementation, and in 1984 StarLAN showed the potential of simple unshielded twisted pair by using Cat3 — the same simple cable used for telephone systems.

However in 2010, only 330, 000 passengers of a potential 11 million Tube passengers claimed compensation for delays.

However, reversible MAOIs lack these hypertensive adverse effects.

However, tricyclic antidepressants are still used because of their effectiveness, especially in severe cases of major depression.

However, combining these drugs with alcohol, opiates or tricyclic antidepressants markedly raises the toxicity.

However, like antidepressants, they have little evidence of effectiveness, although antipsychotics have shown some benefit.

However, tricyclic antidepressants still are probably more successful in treating melancholic depression than other antidepressant drug classes.

However, treatment resistance is widely defined as lack of therapeutic response to two antidepressants at adequate doses for an adequate duration and with good compliance.

However, the competitive nature of serotonin transport inhibition by antidepressants suggests that in neurotransmitter transporters, they bind in a site overlapping the substrate site.

However, they are not recommended as first-line agents ; in acute low back pain, they are not more effective than paracetamol or nonsteroidal anti-inflammatory drugs ( NSAIDs ), and in fibromyalgia they are not more effective than antidepressants.

However, at the recommended dose the risk of seizures is comparable to that observed for other antidepressants.

However, it is important to note that the efficacies of most of the antidepressants in this review differed only slightly.

However, unlike most other antidepressants, though similarly to venlafaxine, these effects are mostly mediated through downstream modulation of the endogenous opioid system, of which in the case of mirtazapine the μ-opioid and κ < sub > 3 </ sub >- opioid receptors are mainly involved.

However, the SNRIs are among the most widely used antidepressants today.

However, psychotherapy, antidepressants, antipsychotics and anti-anxiety medications can play a role when an individual is receptive to intervention.

However in the late 1950s, the first modern antipsychotic and antidepressant drugs were developed: chlorpromazine ( also known as Thorazine ), the first widely-used antipsychotic, was synthesized in 1950, and iproniazid, one of the first antidepressants, was first synthesized in 1957.

However, she soon snaps when Oracle reveals that her mood swings are a side effects of the antidepressants she has been taking to restrain herself, and that Lori has mirrored her mother's own addiction.

However, the reversible MAOI antidepressants such as moclobemide have a very different side effect profile in this regard.

However, it was not of innocence in general that I was speaking, but of perhaps the frailest and surely the least important side of it which is innocence in romantic love.

However, it did not come into general use until Joseph Greenberg ( 1963 ) formally proposed its adoption.

However, in general, the books only feature mental battles when there is some reason for mind-to-mind contact ( for example, Trump contact ) and magic or Trump is involved in all three of the above conflicts, so it is not clear whether Zelazny intended his characters to have such a power ; the combination of Brand's " living trump " powers and his high Psyche ( as presented in the roleplaying game ) would have guaranteed him victory over Corwin.

However, applets have very little control over web page content outside the applet dedicated area, so they are less useful for improving the site appearance in general ( while applets like news tickers or WYSIWYG editors are also known ).

However, in general, an electron's behavior is not fully described by a single orbital.

However, it is used extensively in establishing results about well-ordering and the ordinals in general.

However, very broadly, artillery units are assigned in direct support or in general support.

However, MUL and DIV are special cases, other arithmetic-logical instructions ( ADD, SUB, CMP, AND, OR, XOR, TEST ) may specify any of the eight registers EAX, ECX, EDX, EBX, ESP, EBP, ESI, EDI as the accumulator ( i. e. left operand and destination ); x86 is thus a fairly general register architecture, despite being based on an accumulator model.

However, on 14 May, with considerable skill Marshal Tallard managed to bring 10, 000 reinforcements and vast supplies and munitions through the difficult terrain, whilst outmanoeuvring Baron Thüngen, the Imperial general who sought to block his path.

However, Marlborough would have to wait until Eugene was in position before the general engagement could begin.

However, Bragning is often, like some others of these dynastic names, used in poetry as a general word for ' king ' or ' ruler '.

However, the concentration of gold in its ore is in general very low.

However, it has not incorporated the general Eastern umlaut of all synchronic or even historic " ya " sounds into " e " before front vowels – e. g. поляна ( polyana ) vs полени ( poleni ) " meadow – meadows " or even жаба ( zhaba ) vs жеби ( zhebi ) " frog – frogs ", even though it co-occurs with the yat alternation in almost all Eastern dialects that have it ( except a few dialects along the yat border, e. g. in the Pleven region ).

However, they were later overtaken in the polls by the Conservatives and at the 1983 general election the Conservatives triumphed by a landslide, with Labour once again forming the opposition, while the SDP-Liberal Alliance came close to Labour in terms of votes ( a share of more than 25 %) although it only had 23 MPs compared to Labour's 209.

However, in general it is an integrated approach of fundamental biological sciences and traditional engineering principles.

The Anthropology Library is especially large, with 120, 000 volumes However, the Paul Hamlyn Library, which had become the central reference library of the British Museum and the only library there freely open to the general public, closed permanently in August 2011.

However, the term ' bankruptcy ' is often used when referring to companies in the media and in general conversation.

However, by 1906, the English Court of Appeal had made it clear in the decision of Automatic Self-Cleansing Filter Syndicate Co v Cunningham 2 Ch 34 that the division of powers between the board and the shareholders in general meaning depended on the construction of the articles of association and that, where the powers of management were vested in the board, the general meeting could not interfere with their lawful exercise.

However, Ogden prescribed that any student should learn an additional 150-word list for everyday work in some particular field, by adding a word list of 100 words particularly useful in a general field ( e. g., science, verse, business, etc.

However, this is only a general rule and many species differ.

However, the law of mass action is valid only for concerted one-step reactions that proceed through a single transition state and is not valid in general because rate equations do not, in general, follow the stoichiometry of the reaction as Guldberg and Waage had proposed ( see, for example, nucleophilic aliphatic substitution by S < sub > N </ sub > 1 or reaction of hydrogen and bromine to form hydrogen bromide ).

However, despite claims of government corruption, favoritism of Zaghawas, and abuses by the security forces, opposition party and labor union calls for general strikes and more active demonstrations against the government have been unsuccessful.

However, other professionals that play a more peripheral role in the field of professional sports ( e. g. coaches, general managers, referees, commentators and announcers, sports team owners and executives, sports commissioners ) who are more active in the internal aspects of field tend to remain in obscurity and are less likely to achieve celebrity status.