However, mild hemophilia A ( and B ) is known to occur heterozygous females due to X-inactivation, so it is recommended that levels of factor VIII and IX be measured in all known or potential carriers prior to surgery and in the event of clinically-significant bleeding .< sup >: 1701 </ sup >

However, true palomino coloration is the result of a horse's being heterozygous for the cream dilution gene.

However, the same mutation also conveyed advantages, providing improved viability for heterozygous individuals.

However, convincing evidence indicates, in areas with persistent malaria outbreaks, individuals with the heterozygous state have a distinct advantage ( and this is why individuals with heterozygous alleles are far more common in these areas ).

However, the frequency of heterozygous null-alleles is much higher than expected, indicating a heterozygous advantage for TPI null alleles, as well.

However, when the gene is heterozygous, those lethal genetic mutations do not manifest.

However, the heterozygous cream dilute ( CR ) must not be confused with a horse carrying champagne dilution.

However, if a horse is homozygous for a dominant gene, it will always pass the gene on to all of its offspring, while if the horse is heterozygous for the gene, the offspring will not always inherit the color.

However, in individuals which are heterozygous for an inversion, there is an increased production of abnormal chromatids ( this occurs when crossing-over occurs within the span of the inversion ).

However, because this vulnerability is mutual, it is to the advantage of neither side to destroy the opponent's cities, at least so long as the opponent has nuclear weapons with which to effect reprisal.

However, some home computer manufacturers extended the ASCII character set to take advantage of the advanced color and graphics capabilities of their systems.

However, this advantage is offset by the possibility of developing benzodiazepine dependence.

However, even here the value of cavalry was overrated and the maintenance of large mounted formations at the front by the Russian Army put a major strain on the railway system, to little strategic advantage.

However, some drugs have a better side effect profile than others, enabling doctors to adjust treatment regimens to the advantage of patients in certain situations.

The opening of Korea to foreign Christian missionary activity in the late 19th century saw some improvement in the status of the baekjeong ; However, everyone was not equal under the Christian congregation, and protests erupted when missionaries attempted to integrate them into worship services, with non-baekjeong finding such an attempt insensitive to traditional notions of hierarchical advantage.

However, this advantage is totally negated by the relatively large energy consumption required to simply move the cable over and under the numerous guide rollers and around the many sheaves.

However, carbon dioxide has an advantage in this respect as it kills organisms through hypercarbia and depending on concentration hypoxia and, requiring concentrations of above 35 %, or so.

However, during this conflict, Rome took advantage of the opportunity to strip Carthage of Corsica and Sardinia as well.

However, should a player cross the zone in an attempt to gain an advantage ( e. g., better position ) their team cedes the ball.

However, comparison with a rocket vehicle using similar construction techniques failed to show much advantage, and funding for the vehicle ceased.

However, some users will bypass this danger by using cold water extraction to extract and dispose of a portion of the paracetamol, taking advantage of the water-soluble element of the drug.

However, the clinical literature is very clear that patients whose basal insulin requirements tend not to vary throughout the day or do not require dosage precision smaller than 0. 5 IU, are much less likely to realize much significant advantage of pump therapy.

However, the decisions made by the design team made for a very powerful processor and made possible advanced operating systems like OS-9 and UniFlex, which took advantage of the position-independent, re-entrant nature of the 6809 to create multi-user multitasking operating systems.

However, he is not above selling out his employers if it means a big payoff, a fact which Edison Carter takes advantage of on several occasions while working on stories.

However, developments in shipbuilding elsewhere removed the advantage the Scandinavian countries had previously enjoyed at sea, whilst castle building throughout Europe effectively ended any benefit it might bring.

However, natural selection is " blind " in the sense that changes in phenotype ( physical and behavioral characteristics ) can give a reproductive advantage regardless of whether or not the trait is heritable ( non heritable traits can be the result of environmental factors or the life experience of the organism ).

However, programmers taking advantage of these changes lost backwards compatibility with the unmodified Quake engine.

However, the advantage is that an indexed-color image file can be significantly smaller than it would be with 8 bits per pixel for each primary.

However, newer compression methods such as DEFLATE often use LZ77-based algorithms, a generalization of run-length encoding that can take advantage of runs of strings of characters ( such as ).

However, by exploiting the weaknesses of nonrandom opponents, it is possible to gain a significant advantage.

However, many of the Romulan ships did not have working warp drive, giving UESPA and Starfleet an advantage.

However, Chowdhury suggested that there is a limit beyond which reducing domestic taxes on production cannot confer a competitive advantage versus smuggled cigarettes.

However, the offer came in the form of five discount vouchers to the value of £ 10 each, which were difficult to take advantage of.

However, the Vikings also could not take advantage of the turnover.

However, many would disagree with this hypothesis ; in fact, many of the popular mouthwashes contain sodium lauryl sulfate as an ingredient ( e. g., Listerine Total Care ).

However, the idea that electrons might revolve around a compact nucleus with definite angular momentum was convincingly argued at least 19 years earlier by Niels Bohr, and the Japanese physicist Hantaro Nagaoka published an orbit-based hypothesis for electronic behavior as early as 1904.

However, following a hypothesis suggested by Carington on the basis of his own findings, Soal re-analysed his data for evidence of what Carington termed displacement.

However, in 2009, this hypothesis was disproved when DNA analysis identified the Falkland Island wolf's closest living relative as the Maned Wolf ( Chrysocyon brachyurus )— an unusually long-legged, fox-like South American canid, from which it separated about 6. 7 million years ago.

However, Heather and other scholars are very skeptical of this hypothesis, claiming that there is no archaeological evidence for a substantial emigration from Scandinavia.

However, our understanding of the molecular mechanisms behind genomic imprinting show that it is the maternal genome that controls much of the imprinting of both its own and the paternally-derived genes in the zygote, making it difficult to explain why the maternal genes would willingly relinquish their dominance to that of the paternally-derived genes in light of the conflict hypothesis.

However, this hypothesis is not widely accepted due to lack of evidence for any other animal decline or extinction, even in environmentally sensitive species.

However, a growing number of evidences support an alternative hypothesis from Albert Harris in which cell contractility reshape cell-cell contacts and lead to cell sorting.

However, others of late have come to favour a different hypothesis: that the Frankish Kingdom comprised several regna ( loosely translated as kingdoms ) that since ancient times had maintained different customs and dialects.

However this hypothesis was rejected over time, as evidence accumulated against it.

However, in 1905 Albert Einstein interpreted Planck's quantum hypothesis realistically and used it to explain the photoelectric effect, in which shining light on certain materials can eject electrons from the material.

However, some argue in favor of the “ veil of darkness ” hypothesis, which states that police are less likely to know the race of a driver before they make a stop at nighttime as opposed to in the daytime.

However, the existence of God is viewed as any large-scale hypothesis or explanatory theory that aims to make sense of some pertinent facts.

However, no asteroids trapped in Lagrange points were observed until more than a century after Lagrange's hypothesis.

However, using the ergodic hypothesis, the temperature can still be obtained to arbitrary precision by further averaging the momenta over a long enough time.

However, no randomized, controlled trial of oxalate restriction has yet been performed to test the hypothesis that oxalate restriction reduces the incidence of stone formation.

However, a 2012 review article supports the hypothesis that current or recent trauma may affect an individual's assessment of the more distant past, changing the experience of the past and resulting in dissociative states.

However, a new hypothesis proposes that the C. megalodon and the great white are distant relatives ( albeit sharing the family Lamnidae ).

However, the current popular hypothesis involves a merger of a close binary system in which the orbital angular momentum of the companion is transferred to the primary.

However, much debate continues to this day surrounding this theory, commonly known as the dopamine hypothesis of schizophrenia.

However, this hypothesis is no longer actively investigated.

However, the creole prototype hypothesis has been disputed:

However, the " if " part of this hypothesis is false: for example,, but 341 = 11 × 31 is a pseudoprime.