However, when there's a job to be done, I'm a monstrosity of grim determination, I like to think.

However, when he assumed the duties of a conductor, he relinquished his career as a pianist.

However, as a practicing historian, he, himself, has left few clues to the amount of professional scholarship that he used when writing history.

However, any such suggestion accounts for only some of the difficulties in hearing tone, or in developing a realistic attitude about tone, but not for the analytic difficulties that occur even when tone is meticulously recorded.

However, when labor disputes arise, its provisions come clearly into play.

However, when philosophy attempts to stand above the sciences, to dictate the conditions of empirical research, it becomes formal metaphysics ; ;

However, when volunteers generously placed the interests of others before their own by making charitable donations, another brain circuit was selectively activated: the subgenual cortex / septal region.

However, he had a strong interest in the fledgling motion picture industry and when Essanay Studios offered him the opportunity to become a scriptwriter, he took the job.

However, it would require all data transmission to send eight bits when seven could suffice.

However, the Greeks thought of the two qualities as complementary: the two gods are brothers, and when Apollo at winter left for Hyperborea, he would leave the Delphic oracle to Dionysus.

However, when applied to data from non-randomized experiments or observational studies, model-based analysis lacks the warrant of randomization.

However, when anxiety becomes overwhelming, it may fall under the classification of an anxiety disorder.

However, when forced to choose between Poirot and his wife in that novel, he initially chooses to betray Poirot to the Big Four so that they would not torture and kill his wife.

However, in general, the books only feature mental battles when there is some reason for mind-to-mind contact ( for example, Trump contact ) and magic or Trump is involved in all three of the above conflicts, so it is not clear whether Zelazny intended his characters to have such a power ; the combination of Brand's " living trump " powers and his high Psyche ( as presented in the roleplaying game ) would have guaranteed him victory over Corwin.

However, its intermediate result storage mechanism, a paper card writer / reader, was unreliable, and when inventor John Vincent Atanasoff left Iowa State College for World War II assignments, work on the machine was discontinued.

However, he continued his slave trading career until 1754 or 1755, when he ended his seafaring altogether and began studying Christian theology.

However, the Prosopography of the Later Roman Empire interprets events and sources differently, believing that Alboin married Chlothsind when already a king in or shortly before 561, the year of Chlothar's death.

However, when campaigning against Germanic tribes of Germania, Alexander attempted to bring peace by engaging in diplomacy and bribery.

However, when the time came, Anna quickly and surreptitiously mobilized the remainder of the family and took refuge in the Hagia Sophia.

However, this situation changed drastically when Alexios ' first son John II Komnenos was born in 1087: Anna's engagement to Constantine was dissolved, and she was moved to the main Palace to live with her mother and grandmother.

However, when an Athenian took up an office, he was regarded as ' serving ' the people.

However, the allophone phenomenon becomes obvious when speakers switch languages.

However, when there are complementary allophones of a phoneme, so that the allophony is significant, things become more complicated.

However, in some situations, especially when deep behind enemy lines, the actual attack will be carried out by a platoon, a company-sized unit will be deployed to support the attack group, setting up and maintaining a forward patrol harbour from which the attacking force will deploy, and to which they will retire after the attack.

However, in 2004, Maher concluded that " Physical treatments, such as acupuncture, backschool, hydrotherapy, lumbar supports, magnets, TENS, traction, ultrasound, Pilates therapy, Feldenkrais therapy, Alexander technique, and craniosacral therapy are either of unknown value or ineffective and so should not be considered " when treating lower back pain with an evidence-based approach.

However, the effect of chewing on the intake of macronutrients, such as sugars, fats, and proteins has not been observed.

However, it was well known that proteins are structural and functional macromolecules, some of which carry out enzymatic reactions of cells.

However ADIPOR1 and ADIPOR2 are orientated oppositely to GPCRs in the membrane ( i. e., cytoplasmic N-terminus, extracellular C-terminus ) and do not associate with G proteins.

However, as different lines of research converged, it became clear that some of the same signaling proteins the hematopoietic and immune systems used were also being used by all sorts of other cells and tissues, during development and in the mature organism.

However, proteases do not catalyse the hydrolysis of all kinds of proteins.

However, it is now well-established that some introns themselves encode specific proteins or can be further processed after splicing to generate noncoding RNA molecules.

However, PP-1 needs other proteins like PTG ( Protein Targeted to Glycogen ) to assist.

However, the initial lytic / lysogenic decision on infection is also dependent on the cII and cIII proteins.

However, large proteins must have a specific signaling sequence to be transported across the outer membrane, so the protein composition of this space is different from the protein composition of the cytosol.

However, PrP found in infectious material has a different structure and is resistant to proteases, the enzymes in the body that can normally break down proteins.

However, proteins can become cross-linked, most commonly by disulfide bonds, and the primary structure also requires specifying the cross-linking atoms, e. g., specifying the cysteines involved in the protein's disulfide bonds.

However, mutant p53 proteins often do not induce MDM2, and are thus able to accumulate at very high concentrations.

However, many complex multi-transmembrane proteins contain structural aspects that do not fit the model.

However, intrinsic membrane proteins remain challenging to crystallize because they require detergents or other means to solubilize them in isolation, and such detergents often interfere with crystallization.

However, it took another 20 years before Eugene P. Kennedy described the first ‘ enzymatic phosphorylation of proteins ’.

In a cellular signaling pathways, a protein A phosphorylates protein B, and B phosphorylates C. However, in another signaling pathway, protein D phosphorylates A, or phosphorylates protein C. Global approaches such as phosphoproteomics, the study of phosphorylated proteins, which is a sub-branch of proteomics, combined with mass spectrometry-based proteomics, have been utilised to identify and quantify dynamic changes in phosphorylated proteins over time.

However, since tyrosine phosphorylated proteins are relatively easy to purify using antibodies, tyrosine phosphorylation sites are relatively well understood.

However, the term " tannin " by extension is widely applied to any large polyphenolic compound containing sufficient hydroxyls and other suitable groups ( such as carboxyls ) to form strong complexes with proteins and other macromolecules.

However, CD spectroscopy is a quick method that does not require large amounts of proteins or extensive data processing.

However this is unlikely to be a sufficient cause, as the main construction cost of shells is in creating the proteins and polysaccharides required for the shell's composite structure, not in the precipitation of the mineral components.

However, the classical vaccination approaches that have been successful in the control of various viral diseases by priming the adaptive immunity to recognize the viral envelope proteins have failed in the case of HIV-1.

However, these proteins only represent a small fraction of the total protein set-up necessary to build and maintain the structure and function of a particular type of plastid.

However, some highly specific ' steric chaperones ' do convey unique structural ( steric ) information onto proteins, which cannot be folded spontaneously.

However, γδ T cells are not MHC restricted and seem to be able to recognize whole proteins rather than requiring peptides to be presented by MHC molecules on antigen presenting cells.