The company's stranglehold on the region was broken by the first successful large wagon train to reach Oregon in 1843, led by Marcus Whitman.

* Marcus Whitman ( 1802 – 1847 ), missionary physician who in 1843 convinced President Tyler that Oregon, and what is now the state of Washington, should be secured for the United States not Great Britain.

In 1843, Dr. Marcus Whitman, a missionary who had established a mission near present-day Walla Walla, Washington, led a wagon train westward from the fort, despite pressures from the British.

In 1843 Morton married Elizabeth Whitman of Farmington, Connecticut, the niece of former Congressman Lemuel Whitman.

In 1843 Whitman led the first large party of wagon trains along the Oregon Trail to the West, establishing it as a viable route for the hundreds of thousands of emigrants who used the trail in the following decade.

The Oregon Trail is the oldest component, having been pioneered in the early 1810s and used by the first wagon train, led by Marcus Whitman in 1843.

In early August 1843, just before she turned 25, Stone traveled by train, steamship and stagecoach to Oberlin College in Ohio, the country's first college to admit both women and African Americans.

In 1843, Mann traveled to Germany to investigate how the educational process worked.

In 1843, when Jacobi fell ill, Dirichlet traveled to Königsberg to help him, then obtained for him the assistance of King Friedrich Wilhelm IV's personal physician.

In the summer of 1843, she traveled to Chicago, Milwaukee, Niagara Falls and Buffalo, New York ; while there, she interacted with several Native Americans, including members of the Ottawa and the Chippewa tribes.

In 1843, at the age of 20, he traveled to Europe for eight months in the fashion of the Grand Tour.

In 1843, he traveled to Africa and India to research human races.

Baptized into The Church of Jesus Christ of Latter-day Saints in May 1842, he traveled to Nauvoo, Illinois in 1843.

The university began as the Memphis Conference Female Institute in 1843 and was later renamed in honor of Walter Russell Lambuth ( 1854 – 1921 ), a Methodist missionary who traveled globally during his lifetime.

Baird's tapir is named for the American naturalist Spencer Fullerton Baird, who traveled to Mexico in 1843 and observed the animals.

From 1843 to 1844, Hewitt traveled to Europe with his student, Edward Cooper, the son of industrialist entrepreneur Peter Cooper, and another future New York City mayor.

In 1843, he traveled to Africa and India to research human races.

They traveled to Texas from 1843 to 1847 and settled in the Medina River valley, just west of San Antonio.

Diez, in his flagship work on the topic, Grammatik der romanischen Sprachen, first published in 1836 – 1843 and multiple times thereafter, after enumerating six Romance languages that he compared: Italian and Wallachian ( i. e. Romanian ) ( east ); Spanish and Portuguese ( southwest ); and Provençal and French ( northwest ), asserts that they had their origin in Latin, but nicht aus dem classischen Latein, " not from classical Latin ," rather aus der römischen Volkssprache oder Volksmundart, " from the Roman popular language or popular dialect ".

Fendal Cason, who came to Oregon in 1843, owned an area equal in size east of Portland Avenue.

Education in Chesaning had its beginnings during the summer of 1843 when a small board shanty was built on the east side of the river.

In the 19th century it became established as a fashionable spa town, with the construction of Ben Rhydding Hydro, a Hydropathic Establishment at Wheatley, a mile to the east, between 1843 and 1844.

Frederick August Leuning, who immigrated to the area in 1843, built a cabin near Cedar Creek on what was later the east end of the city.

The Bank Street Presbyterian Church was renamed after Thomas Chalmers, a leader of the 1843 disruption in the Church of Scotland that led to the formation of the Free Church, and in Ottawa, their " parent " congregation of Knox Presbyterian, is now located just two blocks east on Lisgar at Elgin Street.

The Vermont Central Railroad was chartered October 31, 1843 to build a line across the center of Vermont, running from Burlington on Lake Champlain east to Montpelier, and then southeast and south to Windsor on the Connecticut River.

Boone Grove originated as the Ben Grove Post Office in 1843, about 1½ miles north and east of its current location.

In 1843, she accompanied her father in a trip east to Princeton, New Jersey for treaty negotiations.

Ashbee was opened by the Great Eastern Railway on Monday 27 February 1888, replacing a station further to the east which dated from the opening of the branch line from Broxbourne in 1843.

The Meidum Pyramid was excavated by John Shae Perring in 1837, Lepsius in 1843 and then by Flinders Petrie later in the nineteenth century, who located the mortuary temple, facing to the east.

Whenever New England liberalism is reminded of the dramatic confrontation of Parker and the fraternity on January 23, 1843 -- while it may defend the privilege of Chandler Robbins to demand that Parker leave the Association, while it may plead that Dr. N. L. Frothingham had every warrant for stating, `` The difference between Trinitarians and Unitarians is a difference in Christianity ; ;

Abby May wrote in her journal on January 17, 1843, " A day of some excitement, as Mr. Alcott refused to pay his town tax ... After waiting some time to be committed jail, he was told it was paid by a friend.

Work was also progressing on the northern half of the West Wing ( The Egyptian Sculpture Gallery ) 1826 – 1831, with Montagu House demolished in 1842 to make room for the final part of the West Wing, completed in 1846, and the South Wing with its great colonnade, initiated in 1843 and completed in 1847, when the Front Hall and Great Staircase were opened to the public.

In 1843 he visited Italy, and after a stay of thirteen months, went on to Egypt, Sinai, and the Levant, returning by Vienna and Munich.

In 1843, Eli Howes planted his own crop of cranberries on Cape Cod, using the " Howes " variety.

From 1827 to 1843, Britain established a base on the island to combat the slave trade.

Nutmeg was introduced in 1843, when a merchant ship called in on its way to England from the East Indies.

The business was successful enough for Catherine Eiffel to sell the business in 1843 and retire on the proceeds.

He then signed articles on yet another whaler for a six-month cruise ( November 1842 − April 1843 ) and left that ship in Honolulu.

A machine based on Babbage's difference engine was built in 1843 by Per Georg Scheutz and his son Edward.

In the first book on the subject, Neurypnology ( 1843 ), Braid described " hypnotism " as a state of physical relaxation accompanied and induced by mental concentration (" abstraction ").

According to his writings, Braid began to hear reports concerning various Oriental meditative practices soon after the release of his first publication on hypnotism, Neurypnology ( 1843 ).

In 1843, yet another British Army officer in Kingston, Ontario, in Upper Canada, wrote " Began to skate this year, improved quickly and had great fun at hockey on the ice.

Lavish festivals featuring African-based dances to drums were organized on Sundays at Place Congo, or Congo Square, in New Orleans until 1843.

In 1843, Rufus Sage, an explorer and experienced observer recorded jaguar present on the headwaters of the North Platte River 30 – 50 miles north of Long's Peak in Colorado.

The couple married seven years later, on 19 June 1843, at the Wilhelmskirche in Kreuznach.

The town was later annexed to British India when Sindh was annexed by Major-General Charles James Napier at the Battle of Miani on 17 February 1843.

At 34, Carson married his third wife, 14-year-old Josefa, on February 6, 1843.

Five volumes of his Recherches sur les poissons fossiles (" Research on Fossil Fish ") appeared at intervals from 1833 to 1843.

In Stave V of A Christmas Carol, by Charles Dickens ( 1843 ), Scrooge awakes on Christmas morning "... making a perfect Laocoon of himself with his stockings.

* 1843 – The first major wagon train heading for the Pacific Northwest sets out on the Oregon Trail with one thousand pioneers from Elm Grove, Missouri.

It gave the Treasury control of all federal funds and had a legal tender clause that required ( by 1843 ) all payments to be made in specie, but it further inflamed public opinion on both sides.

: The legal definition of insanity has not advanced significantly since 1843 ; in 1953 evidence was given to the Royal Commission on Capital Punishment that doctors even then regarded the legal definition to be obsolete and misleading.

These reforms included guarantees to ensure the Ottoman subjects perfect security for their lives, honour, and property ; the introduction of the first Ottoman paper banknotes ( 1840 ) and opening of the first post offices ( 1840 ); the reorganization of the finance system according to the French model ( 1840 ); the reorganization of the Civil and Criminal Code according to the French model ( 1840 ); the establishment of the Meclis-i Maarif-i Umumiye ( 1841 ) which was the prototype of the First Ottoman Parliament ( 1876 ); the reorganization of the army and a regular method of recruiting, levying the army, and fixing the duration of military service ( 1843 – 44 ); the adoption of an Ottoman national anthem and Ottoman national flag ( 1844 ); the first nationwide Ottoman census in 1844 ( only male citizens were counted ); the first national identity cards ( officially named the Mecidiye identity papers, or informally kafa kağıdı ( head paper ) documents, 1844 ); the institution of a Council of Public Instruction ( 1845 ) and the Ministry of Education ( Mekatib-i Umumiye Nezareti, 1847, which later became the Maarif Nezareti, 1857 ); the abolition of slavery and slave trade ( 1847 ); the establishment of the first modern universities ( darülfünun, 1848 ), academies ( 1848 ) and teacher schools ( darülmuallimin, 1848 ); establishment of the Ministry of Healthcare ( Tıbbiye Nezareti, 1850 ); the Commerce and Trade Code ( 1850 ); establishment of the Academy of Sciences ( Encümen-i Daniş, 1851 ); establishment of the Şirket-i Hayriye which operated the first steam-powered commuter ferries ( 1851 ); the first European style courts ( Meclis-i Ahkam-ı Adliye, 1853 ) and supreme judiciary council ( Meclis-i Ali-yi Tanzimat, 1853 ); establishment of the modern Municipality of Istanbul ( Şehremaneti, 1854 ) and the City Planning Council ( İntizam-ı Şehir Komisyonu, 1855 ); the abolition of the capitation ( Jizya ) tax on non-Muslims, with a regular method of establishing and collecting taxes ( 1856 ); non-Muslims were allowed to become soldiers ( 1856 ); various provisions for the better administration of the public service and advancement of commerce ; the establishment of the first telegraph networks ( 1847 – 1855 ) and railroads ( 1856 ); the replacement of guilds with factories ; the establishment of the Ottoman Central Bank ( originally established as the Bank-ı Osmanî in 1856, and later reorganized as the Bank-ı Osmanî-i Şahane in 1863 ) and the Ottoman Stock Exchange ( Dersaadet Tahvilat Borsası, established in 1866 ); the Land Code ( Arazi Kanunnamesi, 1857 ); permission for private sector publishers and printing firms with the Serbesti-i Kürşad Nizamnamesi ( 1857 ); establishment of the School of Economical and Political Sciences ( Mekteb-i Mülkiye, 1859 ); the Press and Journalism Regulation Code ( Matbuat Nizamnamesi, 1864 ); among others.