Insulin potentiation therapy ( IPT ) is an alternative cancer treatment using insulin to administer low-dose chemotherapy ..

Although both pro-inflammatory and anti-inflammatory types of fat are biologically necessary, fat dietary ratios in most US diets are skewed towards Omega 6, with subsequent disinhibition of inflammation and potentiation of insulin resistance

Conventional insulin therapy has these characteristics:

Its proponents claim insulin therapy increases the uptake of chemotherapeutic drugs by malignant cells, permitting the use of lower total drug doses and reducing side-effects.

The insulin pump is a medical device used for the administration of insulin in the treatment of diabetes mellitus, also known as continuous subcutaneous insulin infusion therapy.

An insulin pump is an alternative to multiple daily injections of insulin by insulin syringe or an insulin pen and allows for intensive insulin therapy when used in conjunction with blood glucose monitoring and carb counting.

* easy delivery of multiple insulin injections for those using intensive insulin therapy.

In North America in 2004, many endocrinologists prefer the term Flexible Insulin Therapy ( FIT ) to " intensive therapy " and use it to refer to any method of replacing insulin that attempts to mimic the pattern of small continuous basal insulin secretion of a working pancreas combined with larger insulin secretions at mealtimes.

Intensive or flexible therapy involves supplying a continual supply of insulin to serve as the basal insulin, supplying meal insulin in doses proportional to nutritional load of the meals, and supplying extra insulin when needed to correct high glucose levels.

The other method of intensive / flexible insulin therapy is an insulin pump.

However, the clinical literature is very clear that patients whose basal insulin requirements tend not to vary throughout the day or do not require dosage precision smaller than 0. 5 IU, are much less likely to realize much significant advantage of pump therapy.

Intensive / flexible insulin therapy requires frequent blood glucose checking.

The proponents of IPT give the following explanation of the biology of cancer and its cells in order to understand the mechanisms of IPT, which relies upon insulin, the most integral component of IPT, having three significant actions upon cancer cells described below, as well as also dropping blood sugar levels and thus the energy source for cancer.

A clinical trial of IPT for treating breast cancer was done in Uruguay and concluded that " The group treated with insulin + methotrexate responded most frequently with stable disease " compared to being treated with methotrexate alone or insulin alone.

Some examples are in improving crop technology ( not a medical application per se ; see BioSystems Engineering ), the manufacture of synthetic human insulin through the use of modified bacteria, the manufacture of erythropoietin in hamster ovary cells, and the production of new types of experimental mice such as the oncomouse ( cancer mouse ) for research.

The main classes of chemotaxis receptors are triggered by formyl peptides-formyl peptide receptors ( FPR ), chemokines-chemokine receptors ( CCR or CXCR ) and leukotrienes-leukotriene receptors ( BLT ); however, induction of a wide set of membrane receptors ( e. g. amino acids, insulin, vasoactive peptides ) also elicit migration of the cell.

Among the causes are excessive insulin produced in the body ( hyperinsulinemia ), inborn error of metabolism, medications and poisons, alcohol, hormone deficiencies, prolonged starvation, alterations of metabolism associated with infection, and organ failure.

Circumstances include the age of the patient, time of day, time since last meal, previous episodes, nutritional status, physical and mental development, drugs or toxins ( especially insulin or other diabetes drugs ), diseases of other organ systems, family history, and response to treatment.

The Omnipod — which integrates the infusion set, tubing, and insulin reservoir — has an automated infusion process that primes the insulin and inserts the cannula to the body automatically after a command from the PDM ( Personal Diabetes Manager ), which controls the insulin pump functions.

Rather than minimize the number of insulin injections per day ( a technique which demands a rigid schedule for food and activities ), the intensive approach favors flexible meal times with variable carbohydrate as well as flexible physical activities.

Furthermore these animals do not have specialized organs ( Islets of Langerhans ), which sense insulin in response to glucose homeostasis.

From left to right are: immunoglobulin G ( IgG, an antibody ), hemoglobin, insulin ( a hormone ), adenylate kinase ( an enzyme ), and glutamine synthetase ( an enzyme ).

Recent animal studies have shown that sweet potatoes, if consumed plain and in modest amounts ( i. e., the opposite of how they are served in traditional soul food dishes ), can stabilize blood sugar levels and lower insulin resistance.

These new early twentieth century physical therapies included malarial therapy for general paresis of the insane ( 1917 ), barbiturate-induced deep sleep therapy ( 1920 ), insulin shock therapy ( 1933 ), cardiazol shock therapy ( 1934 ), and electroconvulsive therapy ( 1938 ).

Insulin resistance in muscle and fat cells reduces glucose uptake ( and also local storage of glucose as glycogen and triglycerides, respectively ), whereas insulin resistance in liver cells results in reduced glycogen synthesis and storage and a failure to suppress glucose production and release into the blood.

Elevated blood fatty-acid concentrations ( associated with insulin resistance and diabetes mellitus Type 2 ), reduced muscle glucose uptake, and increased liver glucose production all contribute to elevated blood glucose levels.

In the presence of a higher than usual level of insulin ( generally caused by insulin resistance ), this down-regulation acts as a kind of positive feedback, increasing the need for insulin.

The result of NAFLD is an excessive release of free fatty acids into the bloodstream ( due to increased lipolysis ), and an increase in hepatic glucose production, both of which have the effect of exacerbating peripheral insulin resistance and increasing the likelihood of Type 2 diabetes mellitus.

If, for instance, such a change is produced by one or a few insulin comas or electroshocks, previously inhibited conditioned reactions reappear.

Modern biotechnology is often associated with the use of genetically altered microorganisms such as E. coli or yeast for the production of substances like synthetic insulin or antibiotics.

According to a 2003 study undertaken by the International Diabetes Federation ( IDF ) on the access to and availability of insulin in its member countries, synthetic ' human ' insulin is considerably more expensive in most countries where both synthetic ' human ' and animal insulin are commercially available: e. g. within European countries the average price of synthetic ' human ' insulin was twice as high as the price of pork insulin.

Yet in its position statement, the IDF writes that " there is no overwhelming evidence to prefer one species of insulin over another " and " highly purified animal insulins remain a perfectly acceptable alternative.

In the case of insulin grown in transgenic plants, it is well-established that the gastrointestinal system breaks the protein down therefore this could not currently be administered as an edible protein.

One of these is resistin which has been linked to obesity, insulin resistance, and Type 2 diabetes.

Cellular recipients of a particular hormonal signal may be one of several cell types that reside within a number of different tissues, as is the case for insulin, which triggers a diverse range of systemic physiological effects.

First, although home glucose meter readings are often misleading, the probability that a low reading, whether accompanied by symptoms or not, represents real hypoglycemia is much higher in a person who takes insulin than in someone who does not.

For example, when the blood glucose is low, hormones which raise the glucose should be rising and insulin secretion should be completely suppressed.

By far, the most common cause of severe hypoglycemia in this age range is insulin injected for type 1 diabetes.

When insulin is deficient or cells become resistant to it, diabetes occurs.

With the exception of the metabolic disorder diabetes mellitus and metabolic syndrome, insulin is provided within the body in a constant proportion to remove excess glucose from the blood, which otherwise would be toxic.

As a consequence, insulin is used medically to treat some forms of diabetes mellitus.

Patients with type 1 diabetes depend on external insulin ( most commonly injected subcutaneously ) for their survival because the hormone is no longer produced internally.

The human insulin protein is composed of 51 amino acids, and has a molecular weight of 5808 Da.

Porcine insulin is especially close to the human version.

The proinsulin precursor of insulin is encoded by the INS gene.