They state that response to any given antipsychotic can be variable so that trials may be necessary, and that lower doses are to be preferred where possible.

Nevertheless, a 2009 systematic review and meta-analysis of trials in people diagnosed with schizophrenia found that less than half ( 41 %) showed any therapeutic response to an antipsychotic, compared to 24 % on placebo, and that there was a decline in treatment response over time, and possibly a bias in which trial results were published.

A review of the methods used in trials of antipsychotics, despite stating that the overall quality is " rather good ," reported issues with the selection of participants ( including that in schizophrenia trials up to 90 % of people who are generally suitable do not meet the elaborate inclusion and exclusion criteria, and that negative symptoms have not been properly assessed despite companies marketing the newer antipsychotics for these ); issues with the design of trials ( including pharmaceutical company funding of most of them, and inadequate experimental " blinding " so that trial participants could sometimes tell whether they were on placebo or not ); and issues with the assessment of outcomes ( including the use of a minimal reduction in scores to show " response ," lack of assessment of quality of life or recovery, a high rate of discontinuation, selective highlighting of favorable results in the abstracts of publications, and poor reporting of side-effects ).

It relates the story of Job, his trials at the hands of Satan, his discussions with friends on the origins and nature of his suffering, his challenge to God, and finally a response from God.

According to Christopher, Rhine did take precautions against cheating in response to criticisms of his methods, but once he did, he was unable to find the same high scores reported in earlier trials.

These studies likewise failed to elicit a positive response by the scientific community despite numerous trials.

Following successful insertion and occlusional response, the Essure procedure is 99. 74 % effective based on 5 years of follow-up, with zero pregnancies reported in clinical trials.

District judges usually concentrate on managing their court's overall caseload, supervising trials, and writing opinions in response to important motions like the motion for summary judgment.

During the first trials ( called escape-trials ) the animal usually experiences both the CS ( Conditioned Stimulus ) and the US ( Unconditioned Stimulus ), showing the operant response to terminate the aversive US.

During later trials, the animal will learn to perform the response already during the presentation of the CS thus preventing the aversive US from occurring.

Clinical trials have shown that after three brief sessions of Pavlovian response conditioning while awake, and subsequent use of a biofeedback headband during sleep, more than 75 % of bruxism sufferers experience more than a 60 % reduction in nighttime clenching from the first day of biofeedback onward, and more than 50 % of bruxism sufferers experience more than an 80 % reduction in bruxism within the first month.

The hypothesis that flower remedies are associated with effects beyond a placebo response is not supported by data from rigorous clinical trials.

Because there is no difference between what is predicted and what happens, no new learning occurs on the additional trials with CS1 + CS2, hence CS2 later yields no response.

An intramuscular vaccine against H. pylori infection is undergoing Phase I clinical trials, and has shown an antibody response against the bacterium.

It was developed in response to Archie Cochrane's call for up-to-date, systematic reviews of all relevant randomized controlled trials of health care.

Although nuts contain various substances thought to possess cardioprotective effects, scientists believe that their Omega 3 fatty acid profile is at least in part responsible for the hypolipidemic response observed in clinical trials.

In 1774, as part of the legislative response to the Boston Tea Party, Parliament considered a bill which would have abolished appeals of murder and trials by battle in the American colonies.

The second is an autologous dendritic cell based vaccine ( GRNVAC1 ), formerly called TVAX when tested in Phase I clinical trials in Prostate Cancer, and it showed significant PSA doubling times as well as T-cell response.

Nitrogen trials under these conditions have shown a maximum seed yield response with the addition of 22 kg / hectare ( 20 lb / acre ) of nitrogen.

The trials were later criticized for failing to recognize the synergistic effects of a large variety of immune factors naturally present in seminal fluid, which, acting together and with the localized presence of the foreign paternal proteins, modulate the female immune response so as to allow for implantation, and then the subsequent immune acceptance of the ( foreign ) fetus throughout a successful pregnancy.

The response was unsatisfactory, and when he found that there were no hopes of advancement, he entered into relations with conspirators who sought the overthrow of the Bourbons.

He noted that 1 ) there was no need for " another pretext for military operation in Chechnya at the time of the Ryazan incident ", but there were already a " plenty of reasons for decisive military response ", 2 ) the FSB of other security service was institutionally incapable of such a conspiracy after years of decline in the 1990s, 3 ) the conspirators were not actually trying to blow a building up in Ryazan ; however, their sloppy actions are " consistent with the training exercise version of events ", 4 ) the FSB did not have to declare the incident a " training exercise ", but " it was much easier to show great relief ... and continue trying to find the perpetrators of the bombing attempt.

In response a group of Irish conspirators launched the Irish Rebellion of 1641, which quickly degenerated into a series of massacres of English and Scottish Protestant settlers in Ireland.

In response to the terrorist attacks she made a statement expressing empathy for the victims, praising President Bush's speech to the U. S. Congress, and calling for justice on the conspirators.

All such imitations of negative quality have given rise to a compensatory response in the form of a heroic and highly individualistic humanism: if man can neither know nor love reality as it is, he can at least invent an artistic `` reality '' which is its own world and which can speak to man of purely personal and subjective qualities capable of being known and worthy of being loved.

When a question contains two verbs, the response does not make clear which of them is being answered.

Additionally, Elihu's first spoken words are a confession of his youthful status, being much younger than the three canonical friends, including a claim to be speaking because he cannot bear to remain silent ; it has been suggested that this interesting statement may have been symbolic of a " younger " ( that is to say, later and interpolating ) writer, who has written Elihu's sermon to respond to what he views as morally and theologically scandalous statements being made within the book of Job, and creating the literary device of Elihu to provide what seemed to be a faith-based response to further refute heresy and provide a counter-argument, a need partially provided by God's ambiguous and unspecific response to Job at the end of the book.

Before Maimonides concluded this, Sunni Muslims officially prohibited mutah ( i. e. temporary marriage ) relationships ; some commentators ' suggest that Maimonides changed his view in response to this development, similar to Gershom ben Judah's ban on polygamy being made after Christians had prohibited it.

Congregational discipline and conflict resolution are applied using various forms of consultation, mediation, and discussion, with disfellowship ( similar to excommunication ) being the final response to those with unorthodox practices or beliefs.

However, the medical view is that the rush or high associated with the activity is not due to adrenaline being released as a response to fear, but due to increased levels of dopamine, endorphins and serotonin because of the high level of physical exertion.

In response to Locke, he put forth in his Treatise Concerning the Principles of Human Knowledge ( 1710 ) an important challenge to empiricism in which things only exist either as a result of their being perceived, or by virtue of the fact that they are an entity doing the perceiving.

Several drug therapies are being developed based on p53, the tumour suppressor gene that protects the cell in response to damage and stress.

Flaming incidents usually arise in response to a perception of one or more negotiation partners being unfair.

Ireland also passed legislation in response to the EU directive with the effective date being 31 December 1993.

SSL does not prevent the entire site from being indexed using a web crawler, and in some cases the URI of the encrypted resource can be inferred by knowing only the intercepted request / response size.

His official reception under the Cupola took place on 22 June 1989, the response to his speech of reception being given by Bertrand Poirot-Delpech.

Logical positivists in response wanted to stop such metaphysical entities from being used as an explanation.

Another scene is of the joke being used in open warfare is shown, with Tommies running through an open field amid artillery fire shouting the joke at the Germans, who die laughing in response.

It was a sardonic response to Mach, which claimed to be a microkernel while being monolithic, essentially unstructured, and slower than the systems it sought to replace.

The proximate environment plays a role in the politics of nations that are angry with their circumstances, an individual or group that becomes angry in response to feelings that they are being exploited usually results in efforts to accommodate them, while being passive results in them being ignored.

For Heidegger, however, communication in the first place is not among human beings, but language itself shapes up in response to questioning ( the inexhaustible meaning of ) being.

It is known, however, that Newton wrote some of the hymns in direct response to events around him ; ' Oh for a closer walk with God ' for instance was written in response to the serious illness then being suffered by Cowper's house companion, Mary Unwin, an illness she survived.