Instead, they cause incorrect folding ( disrupting function ) or disable intracellular transport.

Instead, proteins spend the majority of their folding time – nearly 96 % in some cases – " waiting " in various intermediate conformational states, each a local thermodynamic free energy minimum in the protein's energy landscape.

Instead of a jewel case, the CD comes in a folding wallet made of bright orange vinyl with foam inside, giving it the appearance of a rescue ring or life jacket.

Instead of folding, the team fought to a hard win.

" Instead of continuing the momentum of victory, however, cracks in Allied unity would enable Louis XIV to reverse some of the major setbacks suffered at Turin and Ramillies.

Instead of using abrupt splices or cuts between shots, however, Porter created dissolves, gradual transitions from one image to another.

Instead of prompting a backlash against the movement from which the attackers originated, however, Saudi Arabia, already very conservative, responded by shoring up its fundamentalist credentials with even more Islamic restrictions.

Instead, however, Tiberius ' letter to the Senate, completely unexpectedly, requested the destruction of Sejanus and his faction.

Instead, however, they were blocked by the Quraysh, after which both Muslims and Meccans entered into the Treaty of Hudaybiyyah, whereby the Quraysh promised to cease fighting Muslims and promised that Muslims would be allowed into the city to perform the pilgrimage the following year.

Instead of his converts, however, a group of armed inhabitants appeared who slew the aged archbishop.

Instead of also using E < sub > a </ sub >, however, the Eyring equation uses the concept of Gibbs free energy and the symbol * to denote the energy of the transition state.

Instead, however, he waited for them to finish crossing, and allowed them to marshal their forces.

Instead of cancelling, however, the band hired Nicol to stand in until Ringo recovered.

Instead of this proof, however, they find lists of people Ribaldi has helped.

Instead of celebrating after winning the decisive sixth game at Nassau Coliseum, however, the Islanders were both irate and despondent.

Instead of taunting or challenging Ulala, however, he extends his help to the Channel 5 reporter and together they are able to defeat Morolian Monroe.

Instead of temperature, the pressure in a degenerate gas depends only on the speed of the degenerate particles ; however, adding heat does not increase the speed.

Instead of re-entering coalition with Fianna Fáil under Ahern, however, Spring led Labour into successful coalition negotiations with Fine Gael and the Democratic Left.

Instead however of sending the Artillery and baggage with General Count Walmoden's Column which was furthest from the Enemy, He chose to take them in the rear of His own Column.

Hoenig agreed with Paul Volcker, however, that “ financial market developments ” had caused underwriting corporate bonds ( the prohibition of which Volcker described as the purpose of Glass-Steagall ), and also underwriting of corporate equity, revenue bonds, and “ high quality asset-backed securities ,” to be “ natural extensions of commercial banking .” Instead of reinstating Glass-Steagall prohibitions on such underwriting, Hoenig proposed restoring “ the principles underlying the separation of commercial and investment banking firms .”

Instead of reviving the old free-form programming, however, Maclean-Hunter tweaked the station's programming to create a more conventional modern rock station.

Instead, they claimed to propose legislating for civil union, however attempts by the Labour Party to legislate for civil unions in the previous Dáil were forestalled by PD Minister for Justice, Equality and Law Reform, Michael McDowell, due to his insistence that non-sex relationships be recognised too.

" Instead, however, " he inequality gap is the widest it's been since 1929 ; the middle class is besieged and the working poor are barely keeping their heads above water.

Instead, Clamence decides to flee Paris for London, and takes an indirect route there, moving through North Africa ; however, he meets a friend while in Africa and decides to stay and find work, eventually settling in Tunis.

Instead, he opts for An Hour of Frank Talking, in which he unexpectedly reveals how he came to discover his – hitherto undisclosed – homosexuality ; however, none of the locals turns out to have heard the show, having anticipated a boring hour and chosen not to tune in.

Instead, that function is served by Counties of Sweden ; however, in many instances a county has virtually the same border as the province, which is the case with Värmland and its corresponding county Värmland County.

Instead of the infection and eardrum perforation resolving, however, drainage from the middle ear can become a chronic condition.

Instead Abgarus persuaded him to attack Surena ; however, in the midst of the battle he himself joined the other side.

" Instead he sees Fluxus as a major Neo-Dadaist phenomena within the avant-garde tradition.

" Instead he sees Fluxus as a major Neo-Dadaist phenomena within the avant-garde tradition.

Instead, there was to be a separate Jewish quarter of the city where only Jews lived, where they would enjoy total freedom, and where they could continue to practise their racial customs and culture.

Instead, he goes to Liuhe Pagoda in Hangzhou to practise Buddhism and dies peacefully at the age of 80.

Instead, he constantly became lost in parts and components of them, confused some of their details with those of neighboring objects, and so on, unless he allowed time to `` trace '' the object in question through minute movements of the head and hands and in this way to discover its contours.

Instead, we became involved in a series of friendly, but overly formal, welcoming addresses to which we had no choice but to reply in kind.

Instead, he left home and became a traveling salesman in the American South, peddling books and merchandise.

Instead, he just became confused.

Instead of the original fattoria, the phonetic adaptation American Italian farma ( Weinreich 1963: 49 ) became the new signifier for " farm "— see " one-to-one correlation between signifiers and referents ".

Instead, the migration led to the establishment of a long-lived Celtic territory in central Anatolia, which included the eastern part of ancient Phrygia, a territory that became known as Galatia.

Instead Gardner became friendly with many of the locals, including the Dyak and Dusun people.

Instead of personal duties, money increasingly became the common means to represent economic value in agriculture.

Instead a young Danish Prince became King George I. George was a very popular choice as a constitutional monarch, and he agreed that his sons would be raised in the Greek Orthodox faith.

Instead the offer went to William of Wied, a German prince who accepted and became sovereign of the new Principality of Albania.

Instead, in 1769, he enrolled at the College of New Jersey, now Princeton University, where he became roommates and close friends with Philip Freneau, later dubbed " the poet of the Revolution.

Instead of focusing on talking to the Turks, Ribbentrop and Papen became entangled in a feud over Papen's demand that he by-pass Ribbentrop and send his dispatches straight to Hitler.

Instead, he became one of the youngest winners of an Association of Tennis Professionals ( ATP ) tournament when, as an almost unknown youngster, he won the 1998 Next Generation Adelaide International, defeating Andre Agassi in the semifinals.

Instead he became the leader of Labour's left opposition from the back benches, dazzling the Commons with his command of rhetoric.

Instead, he became the master of the school of Lisbon.

Instead he arranged an exchange of realms with his cousin, Megapenthes, and became king of Tiryns, Megapenthes taking Argos.

Instead, she had Mary, who became quite a tomboy.

Instead, the proceedings became notorious for the large number of demonstrators and the use of force by the Chicago police during what was supposed to be, in the words of the Yippie activist organizers, “ A Festival of Life .” Rioting took place between demonstrators and the Chicago Police Department, who were assisted by the Illinois National Guard.

Instead, his work became focused on landscapes and images of the daily life of Japanese people from a variety of social levels.

Instead of dying, he became a paraplegic.

Instead of a group of eight companions based in the Obsidian Citadel who left periodically to fight evil, the Circle became eight wizards led by a ninth wizard, Gygax's former character Mordenkainen.

Instead, he became a truck driver stationed at the Verdun front.

Instead, defying his father's wishes, Graham became a student at the University of Glasgow in 1819.

Instead, he wrote an orchestral piece based on Thomas Hardy's Wessex, a work that became Egdon Heath and which was first performed a month after Hardy ’ s death, in his memory.

Instead, they proposed that in the aftermath of the giant impact, while the Earth and the proto-lunar disk were molten and vaporized, the two reservoirs were connected by a common silicate vapour atmosphere, and that the Earth – Moon system became homogenized by convective stirring while the system existed in the form of a continuous fluid.