To secure his position as regent, Peter had Afonso marry his daughter, Isabella of Coimbra, in 1445.

Maria Comnena had borne Amalric two daughters: Isabella, who would eventually marry four husbands in turn and succeed as queen, was born in 1172 ; and a stillborn child some time later.

Cesare Borgia had wanted to take over Mantua while Isabella d ' Este was ruling.

Both Barnard and the survivors from the Isabella had harboured concern the other party was Spanish and were relieved to discover their respective nationalities.

Shortly thereafter the Nanina encountered the British ship Nancy under Lt D ' Aranda who had sailed from the River Plate in order to rescue the survivors of the Isabella.

Isabella and Ferdinand had married in 1469 in Valladolid.

In 1856, Isabella attempted to form the Union Liberal Party, a pan-national coalition under the leadership of Leopoldo O ' Donnell, who had already marched on Madrid that year and deposed another Espartero ministry.

Both Warbeck and the Earl of Warwick were too dangerous to keep around even in captivity, and Henry had to execute them in 1499 before Ferdinand and Isabella of Spain would allow their daughter Catherine to come to England and marry his son Arthur.

As the couple had known and admired one another for many years, their mutual attraction deepened into love ; marriage to Francesco allegedly caused Isabella to " bloom ".

Together Isabella and Francesco had eight children:

* Ferrante Gonzaga ( 28 January 1507 – 15 November 1557 ), a condottiero ; married Isabella di Capua, by whom he had issue.

Isabella had given birth to a daughter, Ippolita at about the same time, and she continued to bear him children throughout Francesco and Lucrezia's long, passionate affair, which was more sexual than romantic.

Lucrezia had previously made overtures of friendship to Isabella which the latter had coldly and disdainfully ignored.

From the time Lucrezia had first arrived in Ferrara as Alfonso's intended bride, Isabella, despite having acted as hostess during the wedding festivities, had regarded Lucrezia as a rival, whom she sought to outdo at every opportunity.

Anne of Brittany, Queen consort of Louis XII often copied Isabella, who had a fashion doll made in her likeness.

Isabella had met the French king in Milan in 1500 on a successful diplomatic mission which she had undertaken to protect Mantua from French invasion.

Contemporary chroniclers argued that John had fallen deeply in love with Isabella, and John may have been motivated by desire for an apparently beautiful, if rather young, girl.

Chroniclers recorded that John had a " mad infatuation " with Isabella, and certainly John had conjugal relationships with Isabella between at least 1207 and 1215 ; they had five children.

Isabella d ' Este ( 19 May 1474 – 13 February 1539 ) was Marchesa of Mantua and one of the leading women of the Italian Renaissance as a major cultural and political figure.

The latter's secretary Pietro Bembo described her as " one of the wisest and most fortunate of women ; while the poet Ariosto deemed her the " liberal and magnanimous Isabella ".

As one of their first acts after the war of succession, Ferdinand and Isabella established the centrally organized and efficient Holy Brotherhood ( Santa Hermandad ) as a national police force.

Filomena tells this story, one of the most famous in the Decameron, and the basis of John Keats ' narrative poem Isabella, or the Pot of Basil.

The journey was a pleasant one, with lots of festivities, although Isabella was injured when her tent burned down.

Simon of Reading, one of the Despensers ' supporters, was hanged next to him, on charges of insulting Isabella.

The situation remained tense, however ; Isabella was clearly concerned about Edward's supporters staging a counter-coup, and in November she seized the Tower of London, appointed one of her supporters as mayor and convened a council of nobles and churchmen in Wallingford to discuss the fate of Edward.

At Prince Edward's coronation, Isabella then extended her land holdings from a value of £ 4, 400 each year to the huge sum of £ 13, 333, making her one of the largest landowners in the kingdom.

Edward and Isabella did manage to produce four children, and she suffered at least one miscarriage.

Much of her childhood was spent at Middleham Castle, one of her father's properties, where she and her elder sister, Isabella, met the younger sons of Richard, Duke of York.

It has been established that John and Isabella had at least one child:

When he embraces Isabella one day at the Grange, there is an argument with Edgar which causes Catherine to lock herself in her room and fall ill.

Because of this, when the Duke of York came to power in 1453 – 54, during Henry VI's first period of insanity, negotiations were made between himself and Isabella for a marriage between Charles the Bold, then Count of Charolais, and one of York's unmarried daughters, of whom the 8-year old Margaret was the youngest.

Philip was one of the two chief claimants to the throne along with the demands of Dowager Queen Isabella of England, the late King Charles ' sister, who claimed the French throne for her young son King Edward III of England.

Withdrawn from the descendants on more than one occasion by Richard Coeur-de-Lion, the title passed to King John of England at the time of his marriage to Isabella of Angoulême, daughter of Count Adhémar.

The historian Hernando del Pulgar, contemporary of Ferdinand and Isabella, estimated that the Spanish Inquisition had burned at the stake 2, 000 people by 1490 ( just one decade after the Inquisition began ).

Isabella I of Castile and Ferdinand II of Aragon had several daughters, but only one feeble male heir — Juan.

While most of his siblings supported him, Isabella Beecher Hooker openly supported one of his accusers.

Isabella Mary Beeton ( née Mayson ) ( 12 March 1836 – 6 February 1865 ), universally known as Mrs Beeton, was the English author of Mrs Beeton's Book of Household Management, and is one of the most famous cookery writers.

The Spanish Empire became one of the first global powers as Queen Isabella and King Ferdinand funded Christopher Columbus's exploratory voyage across the Atlantic Ocean.

In 1988 he won a place on the MA fashion design course at the Royal College of Art in London, and in 1989 he took one of his hats to Michael Roberts, fashion editor of Tatler magazine, and his style editor, Isabella Blow.

For Ferdinand of Aragon and Isabella of Castile or possibly Julius II, Bramante designed one of the most harmonious buildings of the Renaissance: the Tempietto ( 1510 ) of San Pietro in Montorio on the Janiculum.

* Isabella ( 1801 – 1886 ) married her cousin Spencer Horatio Walpole in 1835 and was the only one of Perceval's daughters to have children.