Long-term use is controversial due to concerns about adverse psychological and physical effects, increased questioning of effectiveness and because benzodiazepines are prone to cause tolerance, physical dependence, and, upon cessation of use after long term use, a withdrawal syndrome.

Long-term persistent consumption of excessive amounts of alcohol can cause liver damage and have other deleterious health effects.

* Long-term effects of alcohol

Long-term treatment of chronic pain should be monitored with blood tests to assess any adverse effects of the medication on the liver, with the dosages being then changed accordingly, depending on the outcome.

Long-term renal functional effects of shock wave lithotripsy, percutaneous nephrolithotomy and combination therapy: a comparative study of patients with solitary kidney.

* Long-term effects of global warming

Long-term use can precipitate the following effects: negative impact on liver function, permanent tooth darkening ( of a greenish tinge ), susceptibility to ulcers, and diminished sex drive.

Long-term effects:

Long-term side effects are usually mild or moderate in nature.

* Long-term effects of alcohol

Long-term effects of using resveratrol are currently unknown.

Long-term clinical observation has shown that the mechanism is not due to a progressive lesion, given that interruption of stimulation reverses its effects.

Long-term cooling effects are primarily dependent upon injection of sulfide compounds in aerosol forms into the upper atmosphere — the stratosphere — the highest, least active levels of the lower atmosphere where little precipitation occurs, requiring a lengthy time to wash the aerosols out of the region.

Long-term effects of tillage, cover crops, and nitrogen fertilization on organic carbon and nitrogen concentrations in sandy loam soils in Georgia, USA.

Long-term uses of systemic corticosteroids are known to cause many serious side effects and are advisable to avoid, if alternative therapies are available.

Long-term issues in water law include the possible effects of global warming on rainfall patterns and evaporation ; the availability and cost of desalination technology ; the control of pollution, and the growth of aquaculture.

Long-term health effects and interaction with other drugs have not been studied.

Long-term effects can be a permanent changing of a chromosome, which can lead to a mutation.

* Long-term effects of alcohol

Long-term effects on stability:

Long-term secondary effects ( for instance cognitive effects ) on a scale of 10 – 20 years are not yet established for gamma knife surgery.

Long-term effects of benzodiazepines such as nitrazepam include worsening mental and physical health as well as cognitive deficits ; and immunological disturbances.

Long-term effects of benzodiazepine drugs such as nitrazepam include worsening mental and physical health as well as cognitive deficits.

Long-term trials have shown continued effectiveness without the development of tolerance, and, in addition, unlike benzodiazepines, it does not disrupt sleep architecture and produces less severe cognitive and psychomotor impairment ; it also has a low potential for abuse and dependence and may be preferred over the benzodiazepines for these reasons.

Long-term use of benzodiazepines has been associated with increased risk of cognitive impairment, but its relationship with dementia remains inconclusive.

Long-term use of benzodiazepines can worsen underlying anxiety, with evidence that reduction of benzodiazepines can lead to a lessening of anxiety symptoms.

Long-term trials have shown continued effectiveness without the development of tolerance and additionally unlike benzodiazepines it does not disrupt sleep architecture and produces less severe cognitive and psychomotor impairment ; it also has a low potential for abuse and dependence and may be preferred over the benzodiazepines for these reasons.

* Long-term effects of benzodiazepines

* Long-term effects of benzodiazepines

Long-term trials have shown continued effectiveness without the development of tolerance and additionally unlike benzodiazepines it does not disrupt sleep architecture and produces less severe cognitive and psychomotor impairment ; it also has a low potential for abuse and dependence and may be preferred over the benzodiazepines for these reasons.

Long-term issues include:

Long-term problems include inadequate investment in economic infrastructure, rapidly rising medical and pension costs of an aging population, sizable trade and budget deficits, and stagnation of family income in the lower economic groups.

Long-term measures include investment in modern agriculture techniques, such as fertilizers and irrigation, which largely eradicated hunger in the developed world.

Long-term health problems following acute Rocky Mountain spotted fever infection include partial paralysis of the lower extremities, gangrene requiring amputation of fingers, toes, or arms or legs, hearing loss, loss of bowel or bladder control, movement disorders, and language disorders.

Long-term goals for Manila Bay would ideally include the decrease or termination of nearby highly polluting enterprises, implementation effective standards for waste-water discharge and an overall improved water quality.

Long-term plans include reintroduction of the native vegetation.

Long-term campsites include permanent and semi-permanent setups and can lead to closer relationships with neighboring campers

Long-term complications may include gastric cancer and carcinoids.

Long-term projects include the construction of a new 3-story, 150-bed residence hall West of Ross Hall, and a parking structure between Schwitzer Hall and Phi Kappa Psi to expand parking options in the residential zone of the core campus.

Long-term complications can include fistulas between colon or upper rectum and skin or other cavities, or between urethra and perineum.

Long-term problems include inadequate investment in economic infrastructure, rapidly rising medical and pension costs of an aging population, sizable trade and budget deficits.

Long-term plans include the reconstruction of the Brunel-designed building from station on this platform.

Long-term fleet plans may include introduction of wide body aircraft like the Airbus A330, and new Boeing 737s to replace the A320.

Long-term use of sedative-hypnotics for insomnia lacks an evidence base and has traditionally been discouraged for reasons that include concerns about such potential adverse drug effects as cognitive impairment ( anterograde amnesia ), daytime sedation, motor incoordination, and increased risk of motor vehicle accidents and falls.

Long-term use of sedative-hypnotics for insomnia lacks an evidence base and has traditionally been discouraged for reasons that include concerns about such potential adverse drug effects as cognitive impairment ( anterograde amnesia ), daytime sedation, motor incoordination, and increased risk of motor vehicle accidents and falls.

Long-term use of sedative-hypnotics for insomnia lacks an evidence base and is discouraged for reasons that include concerns about such potential adverse drug effects as cognitive impairment ( anterograde amnesia ), daytime sedation, motor incoordination, and increased risk of motor vehicle accidents and falls.

Long-term use of sedative-hypnotics for insomnia lacks an evidence base and has traditionally been discouraged for reasons that include concerns about such potential adverse drug effects as cognitive impairment ( anterograde amnesia ), daytime sedation, motor incoordination, and increased risk of motor vehicle accidents and falls.