[permalink] [id link]
Oxazepam is a benzodiazepine used extensively since the 1960s for the treatment of anxiety and insomnia and in the control of symptoms of alcohol withdrawal.
from
Wikipedia
Some Related Sentences
Oxazepam and is
Oxazepam ( marketed in English speaking countries under the following brand names Alepam, Medopam, Murelax, Noripam, Opamox, Ox-Pam, Purata, Serax and Serepax, as Vaben in Israel, and as Sobril and Oxascand in Sweden and Zaxpam in India ), is a drug which is a short to intermediate acting 3-hydroxy benzodiazepine derivative.
* In the United Kingdom, Oxazepam is available generically in the form of 10 mg, 15 mg and 30 mg tablets.
* In Finland, Oxazepam is available generically in the form of 15 mg, 30 mg and 50 mg tablets.
* In France, Oxazepam is available in the form of 10 mg and 50 mg tablets.
* In Australia, Oxazepam is available in the form of 5 mg, 7. 5 mg, 10 mg, 15 mg and 30 mg tablets.
* In Canada, Oxazepam is available in the form of 15mg tablets that can be split in half made by Apotex.
Oxazepam is contraindicated in Myasthenia gravis, chronic obstructive pulmonary disease and limited pulmonary reserve, as well as severe hepatic disease.
Oxazepam as with other benzodiazepine drugs can cause tolerance, physical dependence, addiction and what is known as the benzodiazepine withdrawal syndrome.
Oxazepam is an intermediate acting benzodiazepine of the 3-hydroxy family.
Oxazepam is the most slowly absorbed benzodiazepine and has the slowest onset of action of all the common benzodiazepines according to one British study.
Oxazepam is an active metabolite formed during the breakdown of diazepam, nordazepam, and certain similar drugs.
Oxazepam may be safer than many other benzodiazepines in patients with impaired liver function because it does not require hepatic oxidation, but rather it is simply metabolized via glucuronidation.
Oxazepam is similar to lorazepam in this respect.
Oxazepam is generally less toxic in overdose than other benzodiazepines.
Oxazepam is a drug with the potential for misuse.
Oxazepam is a Schedule IV drug under the Convention on Psychotropic Substances.
Oxazepam is listed as a possible carcinogen ( Group 2b ) by the IARC.
Oxazepam and benzodiazepine
Oxazepam along with diazepam, nitrazepam and temazepam, were the four benzodiazepines listed on the pharmaceutical benefits scheme and represented 82 % of the benzodiazepine prescriptions in Australia in 1990-1991.
Oxazepam when taken during late in pregnancy, the third trimester, causes a definite risk to the neonate including a severe benzodiazepine withdrawal syndrome in the neonate with symptoms including hypotonia, and reluctance to suck, to apnoeic spells, cyanosis, and impaired metabolic responses to cold stress.
Oxazepam acts on benzodiazepine receptors resulting in increased effect of GABA to the GABA < sub > A </ sub > receptor which results in inhibitory effects on the central nervous system.
Oxazepam and used
Oxazepam and lorazepam are often used in patients at risk of drug accumulation, in particular, the elderly and those with cirrhosis, because they are metabolized differently from other benzodiazepines, through conjugation.
Oxazepam and insomnia
Physicians may use Oxazepam outside its approved indications to treat social phobia, posttraumatic stress disorder, insomnia, premenstrual syndrome, and other conditions.
Oxazepam and .
Oxazepam has moderate amnesic, anxiolytic, anticonvulsant, hypnotic, sedative and skeletal muscle relaxant properties compared to other benzodiazepines.
Oxazepam has been shown to suppress cortisol levels.
is and benzodiazepine
There is a risk of a benzodiazepine withdrawal and rebound syndrome after continuous usage for longer than two weeks, and tolerance and dependence may occur if patients stay under this treatment for longer.
* Tofisopam ( Emandaxin and Grandaxin ) is a drug that is a benzodiazepine derivative.
For this reason, a low dose of a benzodiazepine is often used for several weeks when initiating SSRI / SNRI therapy in order to counteract the initial anxiety caused by the drugs until the therapeutic delay of the SSRI / SNRI is finished and the drug becomes effective.
A benzodiazepine ( sometimes colloquially " benzo "; often abbreviated " BZD ") is a psychoactive drug whose core chemical structure is the fusion of a benzene ring and a diazepine ring.
However, they are much less toxic than their predecessors, the barbiturates, and death rarely results when a benzodiazepine is the only drug taken ; however, when combined with other central nervous system depressants such as alcohol and opiates, the potential for toxicity and fatal overdose increases.
However, this advantage is offset by the possibility of developing benzodiazepine dependence.
Although major concerns about benzodiazepine tolerance and withdrawal have been raised, there is no evidence for significant dose escalation in patients using benzodiazepines long-term.
Chlordiazepoxide is the most commonly used benzodiazepine for alcohol detoxification, but diazepam may be used as an alternative.
Lorazepam is the only benzodiazepine with predictable intramuscular absorption and it is the most effective in preventing and controlling acute seizures.
Caution is exercised in this situation due to the occasional occurrence of respiratory depression, and it is recommended that benzodiazepine overdose treatment facilities should be available.
* Clonazepam, a benzodiazepine is used to treat many forms of parasomnia.
Another view maintains that cognitive deficits in chronic benzodiazepine users occur only for a short period after the dose, or that the anxiety disorders is the cause of these deficits.
Withdrawal symptoms are the new symptoms that occur when the benzodiazepine is stopped.
Antipsychotics are not recommended for benzodiazepine withdrawal ( or other CNS depressant withdrawal states ) especially clozapine, olanzapine or low potency phenothiazines e. g. chlorpromazine as they lower the seizure threshold and can worsen withdrawal effects ; if used extreme caution is required.
The use of flumazenil is controversial following benzodiazepine overdose.
The association of a past history of benzodiazepine use and cognitive decline is unclear, with some studies reporting a lower risk of cognitive decline in former users, some finding no association and some indicating an increased risk of cognitive decline.
There is growing evidence for the effectiveness of NMDA antagonists for benzodiazepine resistant catatonia.
A diagnosis is verified by a benzodiazepine or barbiturate test.
Morphine withdrawal is considered less dangerous than alcohol, barbiturate, or benzodiazepine withdrawal.
Blood tests, lumbar puncture or toxicology screening can be helpful in specific circumstances suggestive of an underlying cause like alcohol or benzodiazepine withdrawal, meningitis or drug overdose, but there is insufficient evidence to support their routine use in the work-up of an adult with an apparently unprovoked first seizure.
0.099 seconds.