Phylogenetic analyses of ITS, nuclear large subunit and mitochondrial small subunit rDNA sequences from a variety of North American species has delineated five distinct clades within the core Laetiporus clade ; sulphureus clade I contains white-pored L. sulphureus isolates, while sulphureus clade II contains yellow-pored L. sulphureus isolates.

Phylogenetic analyses of ITS, nuclear large subunit and mitochondrial small subunit rDNA sequences from a variety of North American species have delineated five distinct clades within the core Laetiporus clade:

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