Selective serotonin reuptake inhibitors ( SSRIs ) are the class of antidepressants commonly used as the first-line treatment for depression because they have a favorable side effect profile and low toxicity.

Selective serotonin reuptake inhibitors ( SSRIs ) selectively block the reuptake of serotonin ( 5-HT ) through their inhibiting effects on the sodium / potassium ATP-dependent serotonin transporter in presynaptic neurons.

Selective serotonin reuptake inhibitors ( SSRIs ) have emerged as first-line therapy.

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