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Several clinical trials have already reported positive results using rAAV to treat Leber's Congenital Amaurosis, showing that the therapy was both safe and effective There were no serious adverse events, and patients in all three studies showed improvement in their visual function as measured by a number of methods.
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Several and clinical
Several clinical and experimental data have implicated the failure of blood – brain barrier ( BBB ) function in triggering chronic or acute seizures, some studies implicate the interactions between a common blood protein — albumin and astrocytes.
Several clinical studies have shown that combined ECPs containing ethinyl estradiol and levonorgestrel can inhibit or delay ovulation .< sup > 107 – 110 </ sup ></ ref >
Several clinical and epidemiological studies conducted in the United States and in the United Kingdom have investigated the occurrence of MCS in military personnel deployed to the Persian Gulf during the 1990s.
Several vaccine candidates are currently in various phases of research and development, including a number of ongoing clinical trials.
Several large studies in the U. K. have produced evidence that demonstrates positive clinical and cost effectiveness of manipulation in the management of lower back pain, the latest being the U. K. Back pain Exercise And Manipulation ( UK BEAM ) trial.
Several clinical and experimental data have implicated the failure of blood – brain barrier function in triggering chronic or acute seizures.
Several clinical ( physical placebos, patient-involved outcomes, falsely informing patients there was no placebo ) and methodological ( small sample size, explicit aim of studying the placebo effect ) factors were associated with higher effects of placebo.
Several vaccine candidates are in varying phases of clinical trials.
Several clinical trials have shown nighttime biofeedback to be effective at substantially reducing nighttime bruxism behavior ( though daytime biofeedback alone has not been shown to be effective at altering nighttime behavior ).
Several clinical studies indicate that supplementation with melatonin is an effective preventive treatment for migraines and cluster headaches.
Several different epidemiological studies indicate antibiotic resistance is increasing in clinical isolates.
Several clinical trials are underway and seeking to apply these methodologies to various limb girdly dystrophies.
Several producers of Chinese herbal medicines are pursuing FDA clinical trials to market their products as drugs in U. S. and European markets.
Several photosensitizers are commercially available for clinical use, such as Allumera, Photofrin, Visudyne, Levulan, Foscan, Metvix, Hexvix, Cysview, and Laserphyrin, with others in development, e. g. Antrin, Photochlor, Photosens, Photrex, Lumacan, Cevira, Visonac, BF-200 ALA. Amphinex.
Several unblinded clinical studies have suggested a benefit of balloon kyphoplasty for patients with spinal fractures.
Several different histological subtypes of rhabdomyosarcoma exist, each of which has different clinical and pathological characteristics.
Several other marine-derived agents are now in clinical trials for indications such as cancer, anti-inflammatory use and pain.
Several studies have reported clinical benefit from gFOBT testing including urology and gynecology clinics.
Several clinical trials are currently underway to investigate the role of PFO in these clinical situations.
Several studies seem to suggest that the mechanisms underlying their evolution may at least in part differ, with consequently possibly different clinical implications.
Several case reports have studied the efficacy of 3 newer antifungal agents in the treatment of disease that is refractory to first-line therapy: posaconazole and voriconazole ( triazole compounds similar in structure to fluconazole ) and caspofungin ( glucan synthesis inhibitor of the echinocandin structural class ). 66, 67 However, these drugs have not been FDA approved, and clinical trials are lacking.
Several recent clinical studies have also suggested that there is a positive correlation between creativity and bipolar disorder, although the relationship between the two is unclear.
Several milestones in medical care and research have taken place at Geisel, including the first clinical X-ray ( 1896 ), the first intensive care unit in the United States ( 1955 ), and the Brattleboro rat ( 1961 ).
Several and trials
Several states require jury trials for all crimes, " petty " or not.
Several hundred such trials have been conducted by investigators over the past 25 years, including those by the Princeton Engineering Anomalies Research Laboratory ( PEAR ) and by scientists at SRI International and Science Applications International Corporation.
Several attempts at creating the vase must have been made, as modern reproduction trials show today ( see below ).
Several types of visual prosthesis are in development or trials in humans, and one device has been approved for sale in the European market.
Several randomized, controlled trials have found that zinc sulfate, consumed orally, often reduces or eliminates warts.
Several of the trials were intended to established tactical methods of using submarines in warfare.
Several trials were held after the war, resulting in the hanging of six Regulators at Hillsborough on June 19, 1771.
Several outbreaks of violence ensued, leading to several arrests and trials.
Several trials were made with the plane, and it is generally recognized that it achieved lift off under its own power after a ski-jump run, glided for a short time and returned safely to the ground, making it the first successful powered flight in history, although the flight was only a short distance and a short time.
Increase Mather and other ministers sent a letter to the Court, " The Return of Several Ministers Consulted ," urging the magistrates not to convict on spectral evidence alone ( spectral evidence was later ruled inadmissible, which caused a dramatic reduction in the rate of convictions and may have hastened the end of the trials ).
Several human intervention trials demonstrated that the antidiabetic effects of fenugreek seeds ameliorate most metabolic symptoms associated with type-1 and type-2 diabetes in both humans and relevant animal models by reducing serum glucose and improving glucose tolerance.
Several variations of this model participated in rifle trials for the U. S. Army of that year ; the Krag-Jørgensen rifle was ultimately chosen.
Several statutes mandating bifurcated trials, with separate guilt-innocence and sentencing phases, and imposing standards to guide the discretion of juries and judges in imposing capital sentences, were upheld in a series of Supreme Court decisions in 1976, led by Gregg v. Georgia.
Several hundred 1882 Lee Navy Models ( M1882 Remington-Lee ) were also subjected to trials by the U. S. Army during the 1880s, though the rifle was not formally adopted.
Several show trials were held in Moscow, to serve as examples for the trials that local courts were expected to carry out elsewhere in the country.
Several independent trials were begun, most notably by Pieter Camper in Groningen and Friesland.
Several randomized, placebo-controlled trials in women with PMDD have clearly demonstrated that the SRIs have excellent efficacy and minimal side effects.
Several and have
Several years of her life have been spent in the homeland, and she had written to friends to alert them of our coming.
Several conventions have been held in recent months in hotels on a nonsegregated basis.
Several dentists and patients with special dental problems have experimented with the device.
Several germanium resistors have been thermally cycled from 300 to 4.2 Af and their resistances have been found to be reproducible within 1/3 millidegree when temperatures were derived from a vapor pressure thermometer whose tubing is jacketed through most of the liquid helium.
Several financial institutions, both banks and insurance companies, have been sounded out.
Several days after the companies had received the questionnaire, members of the research team contacted the presidents of eleven of these companies in person or by phone to discuss any ambiguities or difficulties the addressees might have experienced in completing the questionnaire.
Several signers affixed their names, it was learned, after being told that no tax increase would be possible without consent of the General Assembly and that a provision could be included in the charter to have the town take over the Johnston Sanitary District sewer system.
( Several times recently I have wondered whether shows were being staged for the sake of the script or just to entertain the audience with the spectacle of scenery being shifted right in front of their eyes.
Several of these double entries have been collected by Ben Bagley and Michael McWhinney, along with Rodgers and Hart songs that disappeared permanently en route to New York and others that reached Broadway but have not become part of the constantly heard Rodgers and Hart repertory, in a delightfully refreshing album, Rodgers And Hart Revisited ( Spruce Records, 505 Fifth Avenue, New York ).
Several robot cities have been planned for the country: the first will be built in 2009 at a cost of 500 billion won, of which 50 billion is direct government investment.
Several of the dialects have been influenced by contact with non-Germanic linguistic groups, such as the dialect of Carinthia, where in the past many speakers were bilingual with Slovene, and the dialect of Vienna, which has been influenced by immigration during the Austro-Hungarian period, particularly from what is today the Czech Republic.
Several AFI Alums have received both national and international recognition.
Several unusual applications, such as a nuclear battery or fuel for space ships with nuclear propulsion, have been proposed for the isotope < sup > 242m </ sup > Am, but they are as yet hindered by the scarcity and high price of this nuclear isomer.
Several biographical programs have been made, such as the 2004 BBC television programme entitled Agatha Christie: A Life in Pictures, in which she is portrayed by Olivia Williams, Anna Massey, and Bonnie Wright.
Several additional candidates for written ASL have appeared in over the years, including Sutton SignWriting, Sign Script, ASL-phabet, and Si5s.
Several genres of fiction have been confused as alternate histories.
Several volcanoes on offshore islands have records of historic activity.
Several of Ambrose's works have recently been published in the bilingual Latin-German Fontes Christiani series ( currently edited by Brepols ).
Several religious brotherhoods which have sprung up in and around Milan at various times since the 14th century have been called Ambrosians.
Several saints and six popes have borne this name, including the only English pope, Adrian IV, and the only Dutch pope, Adrian VI.
Several alternatives to the human sacrifice have been presented in Greek mythology.
Several other princes have borne the name Alexander:
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